2021骞�澶╂触澶у(xu茅)纰╁＋鐮旂┒鐢熷叆瀛�(xu茅)鑰冭│鑰冪爺澶х侗

349
钘ュ(xu茅)缍滃悎
涓€銆佽€冭│绺介珨瀹夋帓
1. 瑭﹀嵎鍖呮嫭鏈夋(j墨)鍖栧(xu茅)銆佸垎鏋愬寲瀛�(xu茅)銆佺敓鐗╁(xu茅)/鐢熺墿鍖栧(xu茅)涓夐儴鍒嗚€冮锛屾瘡閮ㄥ垎 150 鍒�?锛熷繉顚ｈ皠?BR>涓换閬稿叐閮ㄥ垎浣滅瓟锛屽叡瑷�(j矛) 300 鍒�銆�
2. 姣忛儴鍒嗚€冮 150 鍒嗕腑锛�120 鍒嗙偤闆欒獮(y菙)鑰冮锛屼腑鑻辨枃浣滅瓟鐨嗗彲锛�30 鍒嗙偤鑻辨枃鑰冮锛岄渶浠ヨ嫳
鏂囦綔绛斻€�
浜�銆佽€冭│绺介珨瑕佹眰
锛堜竴锛夋湁姗�(j墨)鍖栧(xu茅)閮ㄥ垎
杓冪郴绲�(t菕ng)鍦版帉鎻℃湁姗�(j墨)鍖栧(xu茅)鐨勫熀鏈煡璀�(sh铆)銆佸熀鏈蹇�銆傛帉鎻″悇椤炴湁姗�(j墨)鍖栧(xu茅)鍙嶆噳(y墨ng)锛岃兘澶�?q奴)鎳楅矉楗曨€峚(ch菐n)鐗�
鐨勭祼(ji茅)妲�(g貌u)寮忔垨鍙嶆噳(y墨ng)姊濅欢锛屽苟鑳藉鍑哄弽鎳�(y墨ng)閬�(gu貌)绋嬫(j墨)鐞�,鎺屾彙杓冪偤寰�(f霉)闆滃寲鍚堢墿鐨勫悎鎴愭柟娉曘€�
锛堜簩锛夊垎鏋愬寲瀛�(xu茅)閮ㄥ垎
鎺屾彙灏�(du矛)鍖栧悎鐗╃殑瀹氭€�銆佸畾閲忓垎鏋愭柟娉�锛屽叿鍌欑稖鍚堥亱(y霉n)鐢ㄥ垎鏋愬寲瀛�(xu茅)鐭ヨ瓨(sh铆)鍒嗘瀽鍟�(w猫n)椤�銆佽В姹哄晱(w猫n)椤岀殑鑳�
鍔�銆�
锛堜笁锛夌敓鐗╁(xu茅)/鐢熺墿鍖栧(xu茅)閮ㄥ垎
鎺屾彙绱�(x矛)鑳炵祼(ji茅)妲�(g貌u)銆佷唬璎�銆佸懆鏈熴€侀€氳▕鐨勫熀鏈蹇�銆佸師鐞嗕互鍙婅(di脿o)鎺ф(j墨)鍒躲€�
涓�銆佽€冭│鍏�(n猫i)瀹硅垏姣斾緥
锛堜竴锛夋湁姗�(j墨)鍖栧(xu茅)閮ㄥ垎
1锛庢帉鎻℃湁姗�(j墨)鍖栧(xu茅)涓殑鍩烘湰姒傚康銆佽(gu墨)鍓囧拰鍘熺悊銆傛帉鎻″悇椤炴湁姗�(j墨)鍖栧悎鐗╋紙鎸夊畼鑳藉湗(tu谩n)鍒嗛锛夌殑绲�(ji茅)
妲�(g貌u)鍙婂熀鏈弽鎳�(y墨ng)銆傦紙鏈儴鍒嗙磩鍗� 5-20%锛�
2锛庢帉鎻￠浕瀛愭晥鎳�(y墨ng)銆佺珛楂旀晥鎳�(y墨ng)銆佷腑闁撻珨绌�(w臎n)瀹氭€с€佹湁姗�(j墨)鍖栧悎鐗╅吀鍫挎€х瓑鐗╃悊鎬ц兘锛屼互鍙婂畠鍊戝皪(du矛)
鏈夋(j墨)鍖栧悎鐗╂€ц唱(zh矛)鐨勫奖闊�銆傦紙鏈儴鍒嗙磩鍗� 5-20%锛�
3锛庢帉鎻″悇绋寲瀛�(xu茅)鍙嶆噳(y墨ng)鐨勫弽鎳�(y墨ng)姗�(j墨)鐞�銆佸弽鎳�(y墨ng)姊濅欢銆佸強鍖栧悎鐗╃殑鍒跺倷鏂规硶锛岃兘澶�?q奴)鎳楅矉楗曨€栫；?y墨ng)鐢�(ch菐n)
鐗�銆佸弽鎳�(y墨ng)姊濅欢鍙婂弽鎳�(y墨ng)姗�(j墨)鐞�銆傦紙鏈儴鍒嗙磩鍗� 30-70%锛�
4锛庢帉鎻＄珛楂斿寲瀛�(xu茅)鐨勫熀鏈蹇�锛岃兘澶犲垽鏂锋垨?q奴)鎳楅緡纾�?y墨ng)鐢�(ch菐n)鐗╃殑姝ｇ⒑绔嬮珨绲�(ji茅)妲�(g貌u)銆傦紙鏈儴鍒嗙磩鍗�
5-20%锛�
锛堜簩锛夊垎鏋愬寲瀛�(xu茅)閮ㄥ垎
1锛庢帉鎻″垎鏋愬寲瀛�(xu茅)涓暩(sh霉)鎿�(j霉)铏曠悊鏂规硶銆傦紙鏈儴鍒嗙磩鍗� 5-10%锛�
2锛庢帉鎻″寲瀛�(xu茅)瀹氶噺鍒嗘瀽涓悇绋閲忓垎鏋愭硶锛堝寘鎷吀鍫挎淮瀹氥€侀厤浣嶆淮瀹�銆佹哀鍖栭倓鍘熸淮瀹氥€佹矇娣€
婊村畾锛夌殑鍩烘湰鍘熺悊鍙婄浉闂�(gu膩n)姒傚康锛屾淮瀹氭浠剁殑閬告搰鍜屾帶鍒�锛屾淮瀹氬寲瀛�(xu茅)瑷�(j矛)閲忛粸(di菐n)鐨勮▓(j矛)绠�锛屾淮瀹氳宸�
鐨勮▓(j矛)绠楋紝鑳界啛绶村湴鎳�(y墨ng)鐢ㄤ互涓婃柟娉曡В姹哄(sh铆)闅涘晱(w猫n)椤�銆傜啛鎮夐噸閲忓垎鏋愭硶鐨勫熀绀�(ch菙)鐭ヨ瓨(sh铆)鍙婄浉闂�(gu膩n)姒傚康銆傦紙鏈�
閮ㄥ垎绱勫崰 15-30%锛�
3锛庢帉鎻″垎鏋愬寲瀛�(xu茅)涓富瑕佸剙鍣ㄥ垎鏋愭柟娉�銆傦紙鏈儴鍒嗙磩鍗� 60-80%锛�
锛�1锛夐浕浣嶆硶鍙婃案鍋滄淮瀹氭硶锛涳紙0-5%锛�
锛�2锛夊厜璀滄硶锛氱传澶栧彲瑕�(ji脿n)鍒嗗厜鍏夊害娉�銆佺啋鍏夊垎鍏夊厜搴︽硶銆佺磪澶栧垎鍏夊厜搴︽硶銆佸師瀛愬惛鏀跺垎鍏夊厜搴︽硶绛夌殑鍩虹(ch菙)鐞嗚珫锛屽畾鎬�銆佸畾閲忚▓(j矛)绠楁柟娉曞強鎳�(y墨ng)鐢�锛�(15-20%)
锛�3锛夋牳纾佸叡鎸尝璀滄硶鐨勫熀鏈師鐞嗐€佸畾鎬у垎鏋愮殑鎳�(y墨ng)鐢�锛�(5-10%)
锛�4锛夎唱(zh矛)璀滄硶鐨勫熀鏈師鐞嗗強鍏跺湪瀹氭€у垎鏋愪腑鐨勬噳(y墨ng)鐢�锛� (5-10%)
锛�5锛夎壊璀滄硶锛氬钩闈㈣壊璀滄硶銆佹埃鐩歌壊璀滄硶銆侀珮鏁堟恫鐩歌壊璀滄硶鐨勫熀鏈師鐞�锛屽畾鎬�锛屽畾閲忚▓(j矛)绠楀強
鎳�(y墨ng)鐢紱(15-20%)
锛�6锛変笉鍚岄鍨嬫瘺绱�(x矛)绠￠浕娉虫硶鐨勫熀鏈師鐞嗗拰鎳�(y墨ng)鐢�锛�(0-10%)
锛�7锛夌啛鎮夎壊璀滆伅(li谩n)鐢ㄥ垎鏋愭硶锛氳壊璩�(zh矛)鑱�(li谩n)鐢�锛岃壊璀�-鑹茶瓬鑱�(li谩n)鐢ㄥ垎鏋愭硶鐨勭壒榛�(di菐n)銆傦紙0-5%锛�
锛堜笁锛夌敓鐗╁(xu茅)/鐢熺墿鍖栧(xu茅)閮ㄥ垎
1. 鍩烘湰姒傚康锛� 绱�(x矛)鑳炵祼(ji茅)妲�(g貌u)銆佺窗(x矛)鑳炲櫒銆丏NA-铔嬬櫧璩�(zh矛)涓績娉曞墖銆佸洓椤炲ぇ鍒嗗瓙锛堢⒊姘村寲鍚堢墿銆佽剛
椤�銆佽泲鐧借唱(zh矛)鍜屾牳閰革級鐨勫熀鏈祼(ji茅)妲�(g貌u)銆傦紙10%锛�
2. 铔嬬櫧璩�(zh矛)绲�(ji茅)妲�(g貌u)鑸囧姛鑳斤細铔嬬櫧璩�(zh矛)鍚堟垚銆佽泲鐧借唱(zh矛)鐨勪綔鐢ㄥ拰瑾�(di脿o)鎺ф(j墨)鍒�銆佽泲鐧借唱(zh矛)鐨勭爺绌舵柟娉�銆傦紙10%锛�
3. 鑶滅殑绲�(ji茅)妲�(g貌u)浠ュ強鑶滆綁(zhu菐n)閬�(y霉n)锛氳啘鐨勭祫鎴愮祼(ji茅)妲�(g貌u)锛岃啘杞�(zhu菐n)閬�(y霉n)姗�(j墨)鍒�銆佽級楂旇泲鐧戒互鍙婇洟瀛愰€氶亾鍔熻兘锛岀缍�(j墨ng)
绱�(x矛)鑳炵殑闆㈠瓙閫氶亾浠ュ強淇¤櫉(h脿o)鍌冲皫(d菐o)銆� 锛�15%锛�
4. 绱�(x矛)鑳炶兘閲忎唬璎濓細绯栥€佽剛鑲殑浠ｈ瑵浠ュ強瑾�(di脿o)鎺ф(j墨)鍒�锛岀窔绮掗珨鍜屾哀鍖栫７閰稿寲锛岀窔绮掗珨闆诲瓙鍌抽仦
姗�(j墨)鍒�銆傦紙20%锛�
5. 鍩哄洜琛ㄩ仈(d谩)瑾�(di脿o)鎺т互鍙婂熀鍥犲垎鏋愶細杞�(zhu菐n)閷勫拰杞�(zhu菐n)閷勫悗瑾�(di脿o)鎺�銆丏NA 妾㈡脯(c猫)鍜屽厠闅嗘妧琛�(sh霉)銆佸熀鍥犵法杓互鍙�
RNA 骞叉摼鎶€琛�(sh霉)銆傦紙15%锛�
6. 绱�(x矛)鑳為€氳▕锛氱窗(x矛)鑳炰俊铏�(h脿o)鍌冲皫(d菐o)锛孏 铔嬬櫧鍋惰伅(li谩n)鍙楅珨锛岄叾鑱�(li谩n)鍙楅珨銆� 锛�15%锛�
7. 绱�(x矛)鑳炲垎瑁傚懆鏈燂細鍛ㄦ湡鍩烘湰姒傚康浠ュ強鎺у埗绯荤当(t菕ng)锛屾湁绲插垎瑁傘€佺窗(x矛)鑳炴暩(sh霉)閲忓ぇ灏忔帶鍒�銆傦紙15%锛�
鍥涖€佽│鍗烽鍨嬪強姣斾緥
锛堜竴锛夋湁姗�(j墨)鍖栧(xu茅)閮ㄥ垎
瀵敘(ch菐n)鐗╁強鍙嶆噳(y墨ng)姊濅欢椤�銆侀伕鎿囬銆佺啊(ji菐n)绛旈锛屽弽鎳�(y墨ng)姗�(j墨)鐞嗛銆佸悎鎴愰銆傞鍨嬩笉涓€瀹氭瘡娆″懡椤屽悓鏅�(sh铆)鍏�
鏈�锛屽叾涓細閬告搰椤屾垨?q奴)鎳廰(ch菐n)鐗╁強鍙嶆噳(y墨ng)姊濅欢椤岀磩鍗� 40%锛岀啊(ji菐n)绛旈绱勫崰 20%锛屽弽鎳�(y墨ng)姗�(j墨)鐞嗛绱勫崰 20%锛�
鍚堟垚椤岀磩鍗� 20%銆�
锛堜簩锛夊垎鏋愬寲瀛�(xu茅)閮ㄥ垎
鍚嶈瑙ｉ噵鍜岀啊(ji菐n)绛旈鍗� 10-30%锛岄伕鎿囬銆佸垽鏂烽銆佸～绌洪鍜岃▓(j矛)绠楅涓嶄竴瀹氭瘡娆″懡椤屽悓鏅�(sh铆)鍏ㄦ湁锛�
鎵€鍗犳瘮渚嬩篃鏈夎畩鍖�锛岀磩 10-40%锛岀稖鍚堣珫杩伴鍗� 30-50%銆�
锛堜笁锛夌敓鐗╁(xu茅)/鐢熺墿鍖栧(xu茅)閮ㄥ垎
鍒ゆ柗椤岋紙闆欒獮(y菙)锛�銆侀伕鎿囬锛堥洐瑾�(y菙)锛夈€佺啊(ji菐n)绛旈锛堥洐瑾�(y菙)锛�銆佺稖鍚堣珫杩伴锛堣嫳鏂囷級,浠ヤ笂椤屽瀷鍙氦
鏇块亱(y霉n)鐢紙涓嫳鏂囬洐瑾�(y菙)鍑洪锛�銆�
浜斻€佽€冭│褰㈠紡鍙婃檪(sh铆)闁�
1. 鑰冭│褰㈠紡锛氱瓎瑭�锛屾瘡閮ㄥ垎鑰冮 150 鍒嗛悩锛�120 鍒嗙偤闆欒獮(y菙)鑰冮锛屼腑鑻辨枃浣滅瓟鐨嗗彲锛�30 鍒嗙偤
鑻辨枃鑰冮锛岄渶浠ヨ嫳鏂囦綔绛�銆�
2. 鑰冭│鏅�(sh铆)闁擄細涓夊皬鏅�(sh铆)銆�
鍏€佷富瑕佸弮鑰冩暀鏉�
 
锛堜竴锛夋湁姗�(j墨)鍖栧(xu茅)閮ㄥ垎
1. 閭㈠叾姣呯瓑锛屻€婂熀绀�(ch菙)鏈夋(j墨)鍖栧(xu茅)锛堢浜岀増锛夈€嬶紙涓�銆佷笅鍐�(c猫)锛夛紝鍖椾含锛氶珮绛夋暀鑲插嚭鐗堢ぞ锛�1993锛�
2. 鍊矝娲蹭富绶�锛屻€婃湁姗�(j墨)鍖栧(xu茅)銆嬶紙渚涜棩瀛�(xu茅)椤炲皥妤�(y猫)鐢級锛屼汉姘戣(w猫i)鐢熷嚭鐗堢ぞ锛屾渶鏂扮増銆�
3. David Klein, Organic Chemistry, ISSN: 9781118452288, Wiely, 2012.
锛堜簩锛夊垎鏋愬寲瀛�(xu茅)閮ㄥ垎
1.銆婂垎鏋愬寲瀛�(xu茅)銆�锛屾煷閫稿嘲锛岄偢娆ｄ富绶�锛岀鍏増锛屼汉姘戣(w猫i)鐢熷嚭鐗堢ぞ銆�
2. Pharmaceutical Analysis, David G. Watson, Elsevier Press, 2012 (Third edition).
锛堜笁锛夌敓鐗╁(xu茅)/鐢熺墿鍖栧(xu茅)
銆奅ssential Cell Biology 绱�(x矛)鑳炵敓鐗╁(xu茅)绮捐銆�, 鍘熸浉(sh奴)绗笁鐗� 銆愮編銆態.鑹句集鑼ㄧ瓑钁�锛� 涓佸皬鐕曠瓑
璀�銆傜瀛�(xu茅)鍑虹増绀�銆�