鍙嬫儏鎻愮ず锛氭湰绔欐彁渚涘叏鍦�400澶氭墍楂樼瓑闄㈡牎鎷涙敹纰╁+銆佸崥澹爺绌剁敓鍏ュ(xu茅)鑰冭│姝峰勾鑰冪爺鐪熼銆佽€冨崥鐪熼銆佺瓟妗�锛岄儴鍒嗗(xu茅)鏍℃洿鏂拌嚦2012骞�锛�2013骞达紱鍧囨彁渚涙敹璨�(f猫i)涓嬭級銆� 涓嬭級娴佺▼锛� 鑰冪爺鐪熼 榛�(di菐n)鎿娾€�鑰冪爺瑭﹀嵎鈥濃€濅笅杓�; 鑰冨崥鐪熼 榛�(di菐n)鎿娾€�鑰冨崥瑭﹀嵎搴�鈥� 涓嬭級
2020骞村ぇ閫eぇ瀛�(xu茅)鍏ㄥ湅纰╁+鐮旂┒鐢熷叆瀛�(xu茅)鑰冭│銆� 鏈夋(j墨)鍖栧(xu茅) 銆�
鑰冭│澶х侗
涓€銆佽│鍗锋豢鍒嗗強鑰冭│鏅�(sh铆)闁�
婊垮垎鐐�150鍒�锛岃€冭│鏅�(sh铆)闁撶偤180鍒嗛悩銆�
浜�銆佺瓟椤屾柟寮�
绛旈鏂瑰紡鐐洪枆鍗枫€佺瓎瑭�銆�
涓�銆佽│鍗烽鍨嬬祼(ji茅)妲�(g貌u)
閬告搰椤�銆佸垽鏂烽銆佸懡鍚嶉銆佸悎鎴愰銆佸弽鎳�(y墨ng)寮�銆侀憭鍒ラ銆佸弽鎳�(y墨ng)姗�(j墨)鐞嗛銆佹帹灏�(d菐o)绲�(ji茅)妲�(g貌u)
鍥�銆侀仼鐢ㄥ(xu茅)绉�
鍖栧(xu茅)
浜�銆佽€冩牳鍏�(n猫i)瀹�
绉戠洰鍚嶇ū:鏈夋(j墨)鍖栧(xu茅)
1銆佹帉鎻″父瑕嬫湁姗�(j墨)鍖栧悎鐗╃殑绯荤当(t菕ng)鍛藉悕鍜岀繏(x铆)鎱e懡鍚�锛岀啛鎮夌儻鐑寸殑Z/E鍛藉悕瑕�(gu墨)鍓�锛岃兘鍒ゆ柗鎵嬫€у寲鍚堢墿鐨�R/S妲�(g貌u)鍨�锛岀啛鎮夋墜鎬у寲鍚堢墿鐨�Fischer鎶曞奖寮忚〃绀烘硶锛屾帉鎻$啊(ji菐n)鍠洔鐠�(hu谩n)鍖栧悎鐗╃殑鍛藉悕鏂规硶銆�
2銆佹帉鎻¢噸瑕佹湁姗�(j墨)鍖栧悎鐗╃殑鍖栧(xu茅)鎬ц唱(zh矛)鍜屽弽鎳�(y墨ng)瑕�(gu墨)寰�锛岃兘閫�(j矛n)琛屽寲鍚堢墿鐨勭悊鍖栨€ц唱(zh矛)鐨勬瘮杓�銆傞噸榛�(di菐n)瑕佹眰濡備笅锛�
鈶磋嚜鐢卞熀鍙栦唬鍙嶆噳(y墨ng)銆�
鈶电儻鐑寸殑瑕浕鍔犳垚鍙嶆噳(y墨ng)锛岄亷姘у寲鐗╂晥鎳�(y墨ng)锛屾哀鍖栧弽鎳�(y墨ng)鍜岃嚟姘у寲鍙嶆噳(y墨ng)锛岃兘澶犻亱(y霉n)鐢ㄥ叡杌涙晥鎳�(y墨ng)鍜岃秴鍏辫粵鏁堟噳(y墨ng)瑾槑鍒嗗瓙鐨勭┅(w臎n)瀹氭€�銆�
鈶剁倲鐑寸殑鍔犳垚鍙嶆噳(y墨ng)锛屾湯绔倲鐑寸殑鎬ц唱(zh矛)鍙婂叾鍦ㄥ悎鎴愪笂鐨勬噳(y墨ng)鐢�銆�
鈶风挵(hu谩n)宸辩兎鍙婂叾琛嶇敓鐗╃殑妲�(g貌u)璞�銆佺┅(w臎n)瀹氭€с€�
鈶歌姵棣欐棌鍖栧悎鐗╃殑瑕浕鍙栦唬鍙嶆噳(y墨ng)鍙婂畾浣嶈(gu墨)鍓�锛屽彇浠e熀灏�(du矛)鑺崇挵(hu谩n)瑕浕鍙栦唬鍙嶆噳(y墨ng)鐨勬椿鎬у奖闊匡紝绋犵挵(hu谩n)鑺崇兇鐨勬€ц唱(zh矛)锛岄潪鑻姵鐑寸殑鍒ゆ柗銆�
鈶规墜鎬у寲鍚堢墿锛屾棆鍏夋€�锛屾墜鎬х⒊锛屽娑堟棆楂�锛屽収(n猫i)娑堟棆楂旂殑姒傚康銆�
鈶洪沟浠g兇鐨勪竴鑸埗鍌欐柟娉�锛岃Κ鏍稿彇浠e弽鎳�(y墨ng)鍙婂奖闊�SN1锛�SN2鍙嶆噳(y墨ng)鐨勪富瑕佸洜绱�锛屾秷闄ゅ弽鎳�(y墨ng)鍙婂奖闊�E1锛�E2鍙嶆噳(y墨ng)鐨勪富瑕佸洜绱�銆�
鈶婚唶鍜岄啔鐨勫埗鍌�锛岀壒鍒ユ槸閫氶亷Grignard瑭﹀姂鍒堕唶鍜�Williamson鍚堟垚娉曞埗閱氾紝閰氱殑鍒跺倷锛堢:鍖栧牽鐔旀硶鍜岀暟涓欒嫰娉曪級锛岄唶銆侀厷銆侀啔鐨勫寲瀛�(xu茅)鎬ц唱(zh矛)銆�
鈶奸啗銆侀叜鐨勫寲瀛�(xu茅)鎬ц唱(zh矛)鍙婂叾鍦ㄦ湁姗�(j墨)鍚堟垚涓殑鎳�(y墨ng)鐢�锛屾瘮杓冨叾瑕牳鍔犳垚鐨勬椿鎬�銆�
鈶界晶閰稿強鍏惰鐢熺墿鐨勫埗鍌欐柟娉曘€佸寲瀛�(xu茅)鎬ц唱(zh矛)鍜岀浉浜掕綁(zhu菐n)鍖�銆�
鈶句笝浜岄吀浜屼箼閰拰涔欓叞涔欓吀涔欓叝鍦ㄦ湁姗�(j墨)鍚堟垚涓殑鎳�(y墨ng)鐢ㄣ€�
鈶胯兒鐨勫牽鎬уぇ灏忚(gu墨)寰�锛屽閵ㄥ牽鐨勭啽鍒嗚В瑕�(gu墨)寰嬨€�
鈷€閲嶆爱鍖栧悎鐗╁強鍏跺湪鏈夋(j墨)鍚堟垚涓殑鎳�(y墨ng)鐢�銆�
鈷侀洔鐠�(hu谩n)鍖栧悎鐗╃殑绲�(ji茅)妲�(g貌u)鍜屽寲瀛�(xu茅)鎬ц唱(zh矛)銆�
(15)纰虫按鍖栧悎鐗╃殑绲�(ji茅)妲�(g貌u)鍜屽寲瀛�(xu茅)鎬ц唱(zh矛)銆�
(16)姘ㄥ熀閰哥殑绲�(ji茅)妲�(g貌u)鍜屽寲瀛�(xu茅)鎬ц唱(zh矛)銆�
3銆侀潏娲婚亱(y霉n)鐢ㄩ噸瑕佹湁姗�(j墨)鍖栧悎鐗╃殑鍖栧(xu茅)鎬ц唱(zh矛)銆�
4銆佺敤绨�(ji菐n)渚跨殑鍖栧(xu茅)鏂规硶閼掑垾閲嶈鐨勫畼鑳藉湗(tu谩n)鍙婂叾鍖栧悎鐗�銆傚埄鐢ㄥ寲鍚堢墿鐨勬€ц唱(zh矛)灏�(du矛)鐩告噳(y墨ng)鐨勬湁姗�(j墨)鍖栧悎鐗╅€�(j矛n)琛屽垎闆㈠拰鎻愮磾銆傞亱(y霉n)鐢ㄦ湁姗�(j墨)鍖栧(xu茅)鐨勫熀鏈蹇佃В绛斾竴浜涘父瑕嬬殑鍟忛銆�
5銆佹帉鎻″吀鍨嬫湁姗�(j墨)鍙嶆噳(y墨ng)鐨勬(j墨)鐞嗗苟瑙i噵瀵�(sh铆)椹�(y脿n)鐝�(xi脿n)璞°€�
6銆佽兘杓冪啛绶村湴鍒╃敤IR銆�1HNMR璀滃湒鎺ㄥ皫(d菐o)鏈夋(j墨)鍖栧悎鐗╃祼(ji茅)妲�(g貌u)銆�
7銆佽兘杓冪啛绶村湴閬�(y霉n)鐢ㄩ噸瑕佹湁姗�(j墨)鍖栧(xu茅)鍙嶆噳(y墨ng)閫�(j矛n)琛屾湁姗�(j墨)鍚堟垚銆�
鍏�銆佷富瑕佸弮鑰冩暀鏉�
搴忚櫉(h脿o) |
鑰� 瑭� 绉� 鐩� |
鏇� 鐩� |
绶� 鑰� |
鍑虹増绀惧強鍑虹増鏅�(sh铆)闁� |
1 |
鏈夋(j墨)鍖栧(xu茅) |
鏈夋(j墨)鍖栧(xu茅)锛堢浜旂増锛� |
寮垫枃鍕ょ瓑 |
楂樼瓑鏁欒偛鍑虹増绀�锛�2014骞� |
鍏嶈铂(z茅)鑱叉槑锛氭湰鏂囩郴杞�(zhu菐n)杓夎嚜缍�(w菐ng)绲�(lu貌)锛屽鏈変镜鐘�锛岃珛(q菒ng)鑱�(li谩n)绯绘垜鍊戠珛鍗冲埅闄わ紝鍙︼細鏈枃鍍呬唬琛ㄤ綔鑰呭€�(g猫)浜鸿榛�(di菐n)锛岃垏鏈恫(w菐ng)绔欑劇闂�(gu膩n)銆傚叾鍘熷壍(chu脿ng)鎬т互鍙婃枃涓櫝杩版枃瀛楀拰鍏�(n猫i)瀹规湭缍�(j墨ng)鏈珯璀夊(sh铆)锛屽皪(du矛)鏈枃浠ュ強鍏朵腑鍏ㄩ儴鎴栬€呴儴鍒嗗収(n猫i)瀹�銆佹枃瀛楃殑鐪熷(sh铆)鎬�銆佸畬鏁存€�銆佸強鏅�(sh铆)鎬ф湰绔欎笉浣滀换浣曚繚璀夋垨鎵胯锛岃珛(q菒ng)璁€鑰呭儏浣滃弮鑰�锛屽苟璜�(q菒ng)鑷鏍稿(sh铆)鐩搁棞(gu膩n)鍏�(n猫i)瀹广€�