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鍙嬫儏鎻愮ず锛氭湰绔欐彁渚涘叏鍦�400澶氭墍楂樼瓑闄㈡牎鎷涙敹纰╁＋銆佸崥澹爺绌剁敓鍏ュ(xu茅)鑰冭│姝峰勾鑰冪爺鐪熼銆佽€冨崥鐪熼銆佺瓟妗�锛岄儴鍒嗗(xu茅)鏍℃洿鏂拌嚦2012骞�锛�2013骞达紱鍧囨彁渚涙敹璨�(f猫i)涓嬭級銆� 涓嬭級娴佺▼锛� 鑰冪爺鐪熼 榛�(di菐n)鎿娾€�鑰冪爺瑭﹀嵎鈥濃€濅笅杓�; 鑰冨崥鐪熼 榛�(di菐n)鎿娾€�鑰冨崥瑭﹀嵎搴�鈥� 涓嬭級
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锛堜唬纰硷細3966锛�
绗竴閮ㄥ垎 鑰冭│瑾槑
涓€銆� 鑰冭│鎬ц唱(zh矛)
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鐨勫熀绀�(ch菙)涓婏紝娉ㄩ噸鑰冩煡鑰冪敓鐨勮│椹�(y脿n)瑷�(sh猫)瑷�(j矛)鍜岀稖鍚堝垎鏋愬晱椤岀殑鑳藉姏?锛熷繉榉�?y墨ng)鑳芥簴(zh菙n)纰哄湴鎺�
鎻″垎瀛愮敓鐗╁(xu茅)鐨勭悊璜栫煡璀樺拰瀵�(sh铆)椹�(y脿n)鏂规硶锛涘苟灏嶈繎鏈熷湅鍏�(n猫i)澶栬垏钘ュ(xu茅)鏈夐棞(gu膩n)鐨勫垎瀛愮敓鐗╁(xu茅)
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鍙婃牸鎴栧強鏍间互涓婃按骞筹紝浠ヤ繚璀夎閷勫彇鑰呮湁杓冨ソ鐨勭敓鐗╁(xu茅)鐞嗚珫瀵�(sh铆)椹�(y脿n)鍩虹(ch菙)銆�
鑰冭│灏嶈薄鐐哄弮鍔犵暥(d膩ng)骞存垜鏍″崥澹爺绌剁敓鍏ュ(xu茅)鑰冭│鐨勬簴(zh菙n)鑰冭€冪敓銆�
浜�銆� 瑭曞児(ji脿)鐩(bi膩o)
钘ュ(xu茅)鍒嗗瓙鐢熺墿瀛�(xu茅)鍏ュ(xu茅)鑰冭│鍦ㄨ€冩煡鍩烘湰鐭ヨ瓨銆佸熀鏈悊璜栫殑鍩虹(ch菙)涓�锛屾敞閲嶈€冩煡鑰�
鐢熺殑瑭﹂(y脿n)瑷�(sh猫)瑷�(j矛)鑳藉姏锛岀稖鍚堝垎鏋愬晱椤岀殑鑳藉姏?锛熷繉榉�?y墨ng)鑳斤細
1銆佹簴(zh菙n)纰哄湴鍐嶇従(xi脿n)鐢熷寲鑸囧垎瀛愮敓鐗╁(xu茅)鏂归潰鐨勫熀绀�(ch菙)鐭ヨ瓨銆�
2銆佹帉鎻″熀鏈殑鐢熷寲鑸囧垎瀛愮敓鐗╁(xu茅)瀵�(sh铆)椹�(y脿n)鏂规硶銆�
3銆侀亱(y霉n)鐢ㄦ湁闂�(gu膩n)鐭ヨ瓨锛岃В閲嬪拰瑷�(sh猫)瑷�(j矛)瀵�(sh铆)椹�(y脿n)璜栬瓑鏌愮ó鐢熷寲鑸囧垎瀛愮敓鐗╁(xu茅)瀵�(sh铆)椹�(y脿n)鐝�(xi脿n)璞�銆�
4銆佸皪杩戞湡鍦嬪収(n猫i)澶栨湁闂�(gu膩n)鐢熷寲鑸囧垎瀛愮敓鐗╁(xu茅)鏉板嚭鎴愭灉鍙婂墠娌跨煡璀樻噳(y墨ng)鏈夋墍浜嗚В銆�
5銆佹簴(zh菙n)纰恒€佹伆鐣�(d膩ng)?sh霉)鍘ヨ甯界乏W(xu茅)绉戠殑灏堟キ(y猫)琛�(sh霉)瑾�锛屾枃瀛楅€氶爢锛屽堡娆℃竻妤氾紝鏈夎珫鏈夋摎(j霉)锛�
鍚堜箮閭忚集鍦拌〃閬�(d谩)銆�
涓夈€� 鑰冭│褰㈠紡鑸囪│鍗风祼(ji茅)妲�(g貌u)
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2銆� 绛旈鏅�(sh铆)闁擄細180 鍒嗛悩
3銆� 鍚勯儴鍒嗗収(n猫i)瀹圭殑鑰冩煡姣斾緥锛堟豢鍒嗙偤 100 鍒嗭級
鍩虹(ch菙)鐭ヨ瓨 绱� 60%
缍滃悎鑳藉姏 绱� 40%
4銆� 椤屽瀷姣斾緥
鍚嶈瑙ｉ噵 绱� 20-30%
绨＄瓟椤� 绱� 20-30%
瑭﹂(y脿n)瑷�(sh猫)瑷�(j矛)銆佸垎鏋愯珫杩� 绱� 40-60%
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锛堜竴锛� 铔嬬櫧璩�(zh矛)
1銆佽泲鐧借唱(zh矛)鐨勫叡鍍�(ji脿)绲�(ji茅)妲�(g貌u)锛堣偨鍜岃偨閸电殑绲�(ji茅)妲�(g貌u)锛屾皑鍩洪吀娓簭锛孨 绔拰 C 绔皑鍩�
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2銆佽泲鐧借唱(zh矛)鐨勬皑鍩洪吀搴忓垪鍜岀敓鐗╁姛鑳�
3銆佽泲鐧借唱(zh矛)鐨勪簩绱氱祼(ji茅)妲�(g貌u)銆佷笁绱氱祼(ji茅)妲�(g貌u)鍜屽洓绱氱祼(ji茅)妲�(g貌u)
4銆佽泲鐧借唱(zh矛)绲�(ji茅)妲�(g貌u)鍜屽姛鑳界殑闂�(gu膩n)绯�
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2)銆侀叾鏄敓鐗╁偓鍖栧姂锛岄叾浣滅偤鐢熺墿鍌寲鍔戠殑鐗规€�锛岄叾鐨勫寲瀛�(xu茅)鏈唱(zh矛)锛岃紨閰�
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1銆佹煋鑹查珨銆丏NA 鐨勭祼(ji茅)妲�(g貌u)銆佸師鏍歌垏鐪熸牳 DNA 鐨勫京(f霉)鍒剁壒榛�(di菐n)
2銆丏NA 鐨勪慨寰�(f霉)銆丏NA 鐨勮綁(zhu菐n)搴ф(j墨)鍒跺強閬哄偝瀛�(xu茅)鏁堟噳(y墨ng)
5銆� RNA 鐨勭祼(ji茅)妲�(g貌u)銆侀鍨�锛宼RNA 鐨勪笁绱氱祼(ji茅)妲�(g貌u)锛岀湡鏍哥敓鐗� mRNA 绲�(ji茅)妲�(g貌u)鐗归粸(di菐n)锛宺RNA
鐨勫垎椤�, RNAi 鍜� microRNA銆�
(涓�) 鐢熺墿淇℃伅鐨勫偝閬炩€斺€斿緸 DNA 鍒� RNA
1銆丷NA 鐨勮綁(zhu菐n)閷�銆佸暉鍕�(d貌ng)瀛愯垏杞�(zhu菐n)閷勮捣濮�
2銆佸師鏍哥敓鐗╄垏鐪熸牳鐢熺墿 mRNA 鐨勭壒寰佹瘮杓�銆�
3銆佸収(n猫i)鍚瓙鐨勫壀鎺�銆佺法杓強鍖栧(xu茅)淇＞
(鍥�) 鐢熺墿淇℃伅鐨勫偝閬炩€斺€斿緸 DNA 鍒拌泲鐧借唱(zh矛)
1銆侀伜鍌冲瘑纰肩殑鎬ц唱(zh矛)銆�
2銆乼RNA銆佹牳绯栭珨
3銆佽泲鐧借唱(zh矛)鍚堟垚鐨勭敓鐗╁(xu茅)姗�(j墨)鍒�
4銆佽泲鐧借唱(zh矛)閬�(y霉n)杞�(zhu菐n)姗�(j墨)鍒�
(浜�) 鍩哄洜鐨勮〃閬�(d谩)鑸囪(di脿o)鎺р€斺€斿師鏍稿熀鍥犺〃閬�(d谩)瑾�(di脿o)鎺фā寮�
1銆佽綁(zhu菐n)閷勮(di脿o)鎺э細
a.鍘熸牳鐢熺墿锛氫钩绯栨搷绺卞瓙鑸囪矤(f霉)鎺ц獦灏�(d菐o)绯荤当(t菕ng)銆佽壊姘ㄩ吀鎿嶇副瀛愯垏璨�(f霉)鎺ч樆閬忕郴
绲�(t菕ng)
b. 鐪熸牳鐢熺墿锛氬熀鍥犵祼(ji茅)妲�(g貌u)銆佽綁(zhu菐n)閷勬椿鎬у強杞�(zhu菐n)閷勩€傜湡鏍稿熀鍥犺綁(zhu菐n)閷勮(di脿o)鎺х殑涓昏
妯″紡
2銆佽綁(zhu菐n)閷勫悗瑾�(di脿o)鎺э細
a. 鍏�(n猫i)鍚瓙鍓垏鐨勮(di脿o)鎺�銆�
b. RNA 闄嶈В鐨勮(di脿o)鎺�銆�
c. 铔嬬櫧璩�(zh矛)缈昏鍙婇檷瑙ｇ殑瑾�(di脿o)鎺с€�
(鍏�) 钘ュ(xu茅)鍒嗗瓙鐢熺墿瀛�(xu茅)鐨勬噳(y墨ng)鐢�
1銆佽唱(zh矛)绮掑湪澶栨簮铔嬬櫧琛ㄩ仈(d谩)鎶€琛�(sh霉)鐨勬噳(y墨ng)鐢�
2銆佸柈鍏嬮殕鎶楅珨闈跺悜瀹氫綅鎶€琛�(sh霉)鐨勬噳(y墨ng)鐢�
3銆佸弽缇╂牳閰告妧琛�(sh霉)鐨勬噳(y墨ng)鐢�
a. 鍙嶇京鏍搁吀姒傝堪
b. 鍙嶇京鎶€琛�(sh霉)鑸囪棩鐗�
鍏嶈铂(z茅)鑱叉槑锛氭湰鏂囩郴杞�(zhu菐n)杓夎嚜缍�(w菐ng)绲�(lu貌)锛屽鏈変镜鐘�锛岃珛鑱�(li谩n)绯绘垜鍊戠珛鍗冲埅闄わ紝鍙︼細鏈枃鍍呬唬琛ㄤ綔鑰呭€�(g猫)浜鸿榛�(di菐n)锛岃垏鏈恫(w菐ng)绔欑劇闂�(gu膩n)銆傚叾鍘熷壍(chu脿ng)鎬т互鍙婃枃涓櫝杩版枃瀛楀拰鍏�(n猫i)瀹规湭缍�(j墨ng)鏈珯璀夊(sh铆)锛屽皪鏈枃浠ュ強鍏朵腑鍏ㄩ儴鎴栬€呴儴鍒嗗収(n猫i)瀹�銆佹枃瀛楃殑鐪熷(sh铆)鎬с€佸畬鏁存€�銆佸強鏅�(sh铆)鎬ф湰绔欎笉浣滀换浣曚繚璀夋垨鎵胯锛岃珛璁€鑰呭儏浣滃弮鑰�锛屽苟璜嬭嚜琛屾牳瀵�(sh铆)鐩搁棞(gu膩n)鍏�(n猫i)瀹�銆�
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鏂囩珷鎼滅储
鎮ㄧ従(xi脿n)鍦ㄧ殑浣嶇疆锛� 
