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6. 鑲虹壗闀峰弽灏�
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绡€(ji茅)銆�
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锛堝崄锛夌壒娈婃劅瑕哄櫒瀹樼殑鍔熻兘
1.鎰熷彈鍣ㄧ殑涓€鑸敓鐞嗙壒寰�锛屾劅瑕洪€氳矾涓殑淇℃伅绶ㄧ⒓鍜岃檿鐞嗐€�
2.瑕栬锛氱溂鐨勬姌鍏夌郴绲�(t菕ng)鍙婂叾瑾�(di脿o)绡€(ji茅)锛岀溂鐨勬姌鍏夌暟甯革紝鎴挎按鍜岀溂鍏�(n猫i)澹�锛�
鐪肩殑鎰熷厜鎻涜兘鍔熻兘锛岃壊瑕哄強鍏剁敘(ch菐n)鐢熸(j墨)鍒�锛涜鏁忓害銆佹殫閬╂噳(y墨ng)銆佹槑閬╂噳(y墨ng)銆�
瑕栭噹銆佽瑕鸿瀺鍚堢従(xi脿n)璞″拰闆欑溂瑕栬銆�
3.鑱借锛氫汉鑰崇殑鑱介柧鍜岃伣鍩燂紝澶栬€冲拰涓€崇殑鍌抽煶浣滅敤锛岃伈娉㈠偝鍏ュ収(n猫i)
鑰崇殑閫斿緫锛岃€宠澑鐨勬劅闊虫彌鑳戒綔鐢紝浜鸿€冲皪鑱查煶闋荤巼鐨勫垎鏋�銆�
4.骞宠 瑕猴細鍓嶅涵鍣ㄥ畼鐨勯仼瀹滃埡婵€鍜屽钩琛℃劅瑕哄姛鑳姐€傚墠搴弽鎳�(y墨ng)銆�
(鍗佷竴)鍏�(n猫i)鍒嗘硨
1.鍏�(n猫i)鍒嗘硨鐨勬蹇�锛涙縺绱犵殑姒傚康銆佸寲瀛�(xu茅)鍒嗛銆佷綔鐢ㄦ(j墨)鍒跺拰鍒嗘硨瑾�(di脿o)绡€(ji茅)锛�
婵€绱犱綔鐢ㄧ殑涓€鑸壒鎬с€�
2.涓嬩笜鑵�-鑵哄瀭楂旂殑鍔熻兘鑱�(li谩n)绯�锛屼笅涓樿叇瑾�(di脿o)绡€(ji茅)鑲藉拰鑵哄瀭楂旀縺绱犲強鍏跺姛
鑳斤紝鐢熼暦婵€绱犵殑鐢熺悊浣滅敤鍜屽垎娉岃(di脿o)绡€(ji茅)銆備笅涓樿叇-绁炵稉(j墨ng)鍨傞珨鐨勫姛鑳借伅(li谩n)
绯伙紝琛€绠″崌澹撶礌鍜岀府瀹礌鐨勭敓鐞嗕綔鐢�銆�
3.鐢茬媭鑵烘縺绱犵殑鍚堟垚銆佷唬璎�銆佺敓鐞嗕綔鐢ㄥ拰鍒嗘硨瑾�(di脿o)绡€(ji茅)銆�
4.鐢茬媭鏃佽吅婵€绱犲拰闄嶉垼绱犵殑鐢熺悊浣滅敤鍜屽垎娉岃(di脿o)绡€(ji茅)锛岄垼涓夐唶鐨勭敓鐞嗕綔
鐢ㄥ拰鐢熸垚瑾�(di脿o)绡€(ji茅)銆�
5.鑳板扯绱犲拰鑳伴珮琛€绯栫礌鐨勭敓鐞嗕綔鐢ㄥ拰鍒嗘硨瑾�(di脿o)绡€(ji茅)銆�
6.鑵庝笂鑵虹硸鐨唱(zh矛)婵€绱犵殑鐢熺悊浣滅敤鍜屽垎娉岃(di脿o)绡€(ji茅)銆�
7. 鑳板扯绱犲拰鑳伴珮琛€绯栫礌鐨勭敓鐞嗕綔鐢ㄥ拰鍒嗘硨瑾�(di脿o)绡€(ji茅)
(鍗佷簩)鐢熸畺
1.鐢锋€х敓娈栵細鐫父鐨勭敓绮句綔鐢ㄥ拰鍏�(n猫i)鍒嗘硨鍔熻兘锛岀潽涓稿姛鑳界殑瑾�(di脿o)绡€(ji茅)銆�
2.濂虫€х敓娈栵細鍗靛发鐨勭敓鍗典綔鐢ㄥ拰鍏�(n猫i)鍒嗘硨鍔熻兘锛屽嵉宸㈠懆鏈熷拰鏈堢稉(j墨ng)鍛ㄦ湡锛�
鍗靛发鍔熻兘鐨勮(di脿o)绡€(ji茅)锛涘濞犲拰鍒嗗ī銆�
浜屻€佺敓鐗╁寲瀛�(xu茅)
锛堜竴锛夎泲鐧借唱(zh矛)鐨勭祼(ji茅)妲�(g貌u)鑸囧姛鑳�
1.铔嬬櫧璩�(zh矛)鐨勫垎瀛愮祫鎴愶細铔嬬櫧璩�(zh矛)鐨勫熀鏈祼(ji茅)妲�(g貌u)鍠綅锛涙皑鍩洪吀鐨勫垎椤�锛涙皑
鍩洪吀鐨勭悊鍖栨€ц唱(zh矛)锛涘鑲借垏鐢熺墿娲绘€у鑲�锛涜泲鐧借唱(zh矛)鐨勫垎椤炪€�
2.铔嬬櫧璩�(zh矛)鐨勫垎瀛愮祼(ji茅)妲�(g貌u)锛氳泲鐧借唱(zh矛)鐨勪竴绱氱祼(ji茅)妲�(g貌u)锛涜泲鐧借唱(zh矛)鐨勪簩绱氱祼(ji茅)妲�(g貌u)锛涜泲
鐧借唱(zh矛)鐨勪笁绱氱祼(ji茅)妲�(g貌u)锛涜泲鐧借唱(zh矛)鐨勫洓绱氱祼(ji茅)妲�(g貌u)銆�
3.铔嬬櫧璩�(zh矛)鐨勭祼(ji茅)妲�(g貌u)鑸囧姛鑳界殑闂�(gu膩n)绯伙細铔嬬櫧璩�(zh矛)鐨勪竴绱氱祼(ji茅)妲�(g貌u)鑸囧姛鑳界殑闂�(gu膩n)绯伙紱
铔嬬櫧璩�(zh矛)鐨勭┖闁撶祼(ji茅)妲�(g貌u)鑸囧姛鑳界殑闂�(gu膩n)绯�銆�
4.铔嬬櫧璩�(zh矛)鐨勭悊鍖栨€ц唱(zh矛)锛氳泲鐧借唱(zh矛)鐨勭悊鍖栨€ц唱(zh矛)锛涜泲鐧借唱(zh矛)鑶犻珨鎬ц唱(zh矛)锛涜泲鐧�
璩�(zh矛)鐨勮畩鎬ц垏寰�(f霉)鎬э紱绱鍚告敹锛涜寶涓夐叜鍙嶆噳(y墨ng)鍜岄洐绺劜鍙嶆噳(y墨ng)銆�
5.铔嬬櫧璩�(zh矛)鐨勫垎闆�銆佺磾鍖栬垏绲�(ji茅)妲�(g貌u)鍒嗘瀽锛氳泲鐧借唱(zh矛)鐨勪笝閰矇娣€銆佺～閰搁姩楣�
鏋�銆侀浕娉炽€侀€忔瀽銆佸堡鏋愩€佸嚌鑶犻亷婵惧強瓒呴€熼洟蹇冪瓑鍒嗛洟绱斿寲鏂规硶鐨勫熀
鏈師鐞�锛涘鑲介張涓皑鍩洪吀搴忓垪鍒嗘瀽锛涜泲鐧借唱(zh矛)绌洪枔绲�(ji茅)妲�(g貌u)娓畾銆�
锛堜簩锛夐叾
1.閰剁殑鍒嗗瓙绲�(ji茅)妲�(g貌u)鑸囧姛鑳斤細閰剁殑浣滅敤鐗归粸(di菐n)锛涢叾鐨勫寲瀛�(xu茅)绲�(ji茅)妲�(g貌u)锛涢叾鐨勬椿鎬�
涓績鑸囧偓鍖栨椿鎬�锛涘悓宸ラ叾銆�
2.閰剁殑宸ヤ綔鍘熺悊锛氶叾淇冨弽鎳�(y墨ng)娲诲寲鑳�锛涢叾楂樻晥鍌寲浣滅敤鐨勬(j墨)鍒躲€�
3.閰朵績鍙嶆噳(y墨ng)鍕曞姏瀛�(xu茅)锛氬簳鐗╂績搴﹀皪鍙嶆噳(y墨ng)閫熷害鐨勫奖闊�锛涢叾婵冨害灏嶅弽鎳�(y墨ng)閫�
搴︾殑褰遍熆锛涙韩搴﹀皪鍙嶆噳(y墨ng)閫熷害鐨勫奖闊匡紱pH 灏嶅弽鎳�(y墨ng)閫熷害鐨勫奖闊�锛涙姂鍒�
鍔戝皪鍙嶆噳(y墨ng)閫熷害鐨勫奖闊�锛涙縺娲诲姂灏嶅弽鎳�(y墨ng)閫熷害鐨勫奖闊�銆�
4.閰剁殑瑾�(di脿o)绡€(ji茅)锛氶叾娲绘€х殑瑾�(di脿o)绡€(ji茅)锛涢叾鍚噺鐨勮(di脿o)绡€(ji茅)
5.閰剁殑鍛藉悕鑸囧垎椤�銆�
6.閰惰垏閱�(y墨)瀛�(xu茅)鐨勯棞(gu膩n)绯伙細閰惰垏鐤剧梾鐨勭櫦(f膩)鐢�銆佽ê鏂峰強娌荤檪锛涢叾鑸囪嚚搴婃椹�(y脿n)
鍙婄瀛�(xu茅)鐮旂┒銆�
锛堜笁锛夌硸浠ｈ瑵
1.绯栫殑娑堝寲鍚告敹鍙婂叾鍦ㄩ珨鍏�(n猫i)浠ｈ瑵姒傛硜锛氱硸鐨勬秷鍖栬垏鍚告敹锛涚硸浠ｈ瑵鐨�
姒傛硜銆�
2.绯栫殑鐒℃哀姘у寲锛氱硸鐨勭劇姘ф哀鍖栭亷绋�锛涚硸閰佃В鐨勮(di脿o)绡€(ji茅)锛涚硸閰佃В鐨勭敓
鐞嗘剰缇�銆�
3.绯栫殑鏈夋哀姘у寲锛氱硸鐨勬湁姘ф哀鍖栭亷绋�锛涚硸鏈夋哀姘у寲鐢熸垚鐨� ATP锛涚硸
鏈夋哀姘у寲鐨勮(di脿o)绡€(ji茅)銆�
4.纾烽吀鎴婄硸閫斿緫锛氱７閰告垔绯栭€斿緫鐨勫弽鎳�(y墨ng)閬庣▼锛涚７閰告垔绯栭€斿緫鐨勭敓鐞�
鎰忕京銆�
5.绯栧師鐨勫悎鎴愯垏鍒嗚В锛氱硸鍘熺殑鍚堟垚浠ｈ瑵锛涚硸鍘熺殑鍒嗚В浠ｈ瑵锛涚硸鍘熺殑
鍚堟垚鑸囧垎瑙ｇ殑瑾�(di脿o)绡€(ji茅)锛涚硸鍘熺疮绌嶇櫏鎬ц唱(zh矛)銆佺壒榛�(di菐n)鍙婂垎鍨嬨€�
6.绯栫暟鐢燂細绯栫暟鐢熼€斿緫锛涚硸鐣扮敓鐨勮(di脿o)绡€(ji茅)锛涚硸鐣扮敓鐨勭敓鐞嗘剰缇�锛涗钩閰�
寰挵(hu谩n)銆�
7.琛€绯栧強鍏惰(di脿o)绡€(ji茅)锛氳绯栫殑渚嗘簮鍜屽幓璺�锛涜绯栨按骞崇殑瑾�(di脿o)绡€(ji茅)锛涚硸浠ｈ瑵绱�
浜�銆�
锛堝洓锛夎剛璩�(zh矛)浠ｈ瑵
1.鑴傝唱(zh矛)鍒嗛鑸囧懡鍚嶅強鍏跺姛鑳斤細鑴傝偑锛涢鑴�锛涜剛鑲吀鐨勫垎椤炲強鍛藉悕锛�
骞剧ó澶氫笉椋藉拰鑴傝偑閰歌鐢熺墿銆�
2.鑴傞鐨勬秷鍖栧拰鍚告敹锛氭秷鍖栭叾椤炪€佹贩鍚堝井鍦�(tu谩n)銆佷钩绯滃井绮�銆佺敇娌逛竴閰�
鍚堟垚閫斿緫
3.鐢樻补涓夐叝鐨勪唬璎濓細鐢樻补涓夐叝鐨勫垎瑙ｄ唬璎�锛涜剛鑲吀鐨勫悎鎴愪唬璎�锛涚敇
娌逛笁閰殑鍚堟垚銆�
4.纾疯剛鐨勪唬璎濓細鐢樻补纾疯剛鐨勪唬璎�锛涢灅纾疯剛鐨勪唬璎濄€�
5.鑶藉浐閱囦唬璎濓細鑶藉浐閱囩殑鍚堟垚鑸囪(di脿o)绡€(ji茅)锛涜喗鍥洪唶鐨勮綁(zhu菐n)鍖�銆�
6.琛€婕胯剛铔嬬櫧浠ｈ瑵锛氳鑴傝垏琛€婕胯剛铔嬬櫧锛涜婕胯剛铔嬬櫧浠ｈ瑵銆�
7 鑴傝唱(zh矛)浠ｈ瑵绱婁簜鍙婄柧鐥咃細閰鐧�锛涜剛鑲倽锛涢珮鑴傝泲鐧借鐧ヨ婕胯剛铔�
鐧戒唬璎濈磰浜傝垏鍕曡剤绮ユǎ纭寲銆�
锛堜簲锛夌敓鐗╂哀鍖�
1.楂斿収(n猫i)鑳介噺鐨勮帛瀛樿垏鍒╃敤褰㈠紡锛欰TP锛涚７閰歌倢閰�锛涙哀鍖栫７閰稿寲鏄渶
涓昏鐨� ATP 鐢熸垚鏂瑰紡銆�
2.闆诲瓙鍌抽仦閺堢殑绲勬垚鍙婂姛鑳斤細姘у寲鍛煎惛閺堢殑绲勬垚锛涚窔绮掗珨涓噸瑕佺殑
闆诲瓙杓夐珨锛涢浕瀛愬偝閬為張涓悇寰�(f霉)鍚堥珨鐨勭祫鎴愬強鍔熻兘锛涢浕瀛愬偝閬為張鐨勯浕
瀛愪緵楂�锛涢浕瀛愬偝閬為張鐨勫姛鑳�銆�
3.姘у寲纾烽吀鍖栵細姘у寲纾烽吀鍖栧伓鑱�(li谩n)姗�(j墨)鍒�锛汚TP 鍚堥叾鍚堟垚 ATP锛涙哀鍖栫７
閰稿寲鍋惰伅(li谩n)閮ㄤ綅銆�
4.姘у寲纾烽吀鍖栫殑褰遍熆鍥犵礌锛氭哀鍖栫７閰稿寲鐩搁棞(gu膩n)搴曠墿鐨勫奖闊垮強鍏惰綁(zhu菐n)閬�(y霉n)锛�
楂斿収(n猫i)鑳介噺渚涙噳(y墨ng)鐙€鎱�(t脿i)褰遍熆姘у寲纾烽吀鍖�锛涙哀鍖栫７閰稿寲鎶戝埗鍔�锛涚敳鐙€鑵烘縺
绱犵殑瑾�(di脿o)绡€(ji茅)浣滅敤锛涚窔绮掗珨 DNA 绐佽畩鐨勫奖闊�銆�
5.闈炶兘閲忎唬璎濈殑鐢熺墿姘у寲鍙嶆噳(y墨ng)锛氭椿鎬ф哀锛涢珨鍏�(n猫i)鎶楁哀鍖栭珨绯汇€�
锛堝叚锛夋皑鍩洪吀浠ｈ瑵
1.铔嬬櫧璩�(zh矛)鐨勭嚐椁�(y菐ng)浣滅敤锛氳泲鐧借唱(zh矛)鐨勭敓鐞嗗姛鑳�锛涗汉楂斿皪铔嬬櫧璩�(zh矛)鐨勯渶瑕侀噺锛�
铔嬬櫧璩�(zh矛)鐨勭嚐椁�(y菐ng)鍍瑰€�銆�
2.铔嬬櫧璩�(zh矛)鐨勬秷鍖�銆佸惛鏀惰垏鑵�?銆傛棻闉嶈釜|(zh矛)鐨勬秷鍖栵紱姘ㄥ熀閰稿拰瀵¤偨鐨勫惛
鏀�锛涜吀涓殑鐨勮厫鏁椾綔鐢ㄣ€�
3.姘ㄥ熀閰哥殑涓€鑸唬璎濓細铔嬬櫧璩�(zh矛)鐨勫垎瑙�锛涙皑鍩洪吀浠ｈ瑵搴�锛涙皑鍩洪吀鐨勮劔
姘ㄥ熀浣滅敤锛浳�-閰吀鐨勪唬璎�銆�
4.姘ㄧ殑浠ｈ瑵锛氳姘ㄧ殑渚嗘簮锛涙皑鐨勮綁(zhu菐n)閬�(y霉n)锛涙皑鐨勫幓璺€�
5.鍊嬪垾姘ㄥ熀閰哥殑浠ｈ瑵锛氭皑鍩洪吀鐨勮劔缇у熀浣滅敤锛涗竴纰冲柈浣嶄唬璎濓紱鍚～
姘ㄥ熀閰镐唬璎�锛涜姵棣欐棌姘ㄥ熀閰镐唬璎�锛涙敮閺堟皑鍩洪吀浠ｈ瑵銆�
锛堜竷锛夌窗(x矛)鑳炰俊鎭綁(zhu菐n)灏�(d菐o)
1.淇℃伅鐗╄唱(zh矛)锛氱窗(x矛)鑳為枔鐨勪俊鎭墿璩�(zh矛)锛涚窗(x矛)鑳炲収(n猫i)鐨勪俊鎭墿璩�(zh矛)銆�
2.鍙楅珨锛氬彈楂旂殑瀹氱京鑸囩壒鎬�锛涘彈楂旂殑鍒嗛鍙婄祼(ji茅)妲�(g貌u)锛涘彈楂旀椿鎬х殑瑾�(di脿o)绡€(ji茅)銆�
3.鍙楅珨浠嬪皫(d菐o)鐨勪俊铏熻綁(zhu菐n)灏�(d菐o)閫氳矾锛歊as-MAPK 淇¤櫉閫氳矾鑸� PI3K-AKT 淇¤櫉
閫氳矾锛汚C-cAMP-PKA 淇¤櫉閫氳矾锛汸LC-IP3/DAG-PKC 淇¤櫉閫氳矾锛�
JAK-STAT 淇¤櫉閫氳矾锛汵F-魏螔淇¤櫉閫氳矾銆�
4.淇¤櫉杞�(zhu菐n)灏�(d菐o)绯荤当(t菕ng)鐨勭壒榛�(di菐n)鍙婂叾浜や簰鑱�(li谩n)绯伙細鍙楅珨浠嬪皫(d菐o)鐨勪俊铏熻綁(zhu菐n)灏�(d菐o)鐗归粸(di菐n)锛�
淇¤櫉杞�(zhu菐n)灏�(d菐o)閫氳矾鐨勫妯ｆ€ц垏浜や簰鑱�(li谩n)绯�銆�
5.淇℃伅杞�(zhu菐n)灏�(d菐o)鐣板父鑸囩柧?銆傜瘡 铔嬬櫧鍋惰伅(li谩n)鍙楅珨鐣板父鍙婄浉闂�(gu膩n)鐤剧梾锛涢叒姘ㄩ吀
铔嬬櫧婵€閰跺彈楂旂暟甯歌垏鐤剧梾锛涗俊铏熻綁(zhu菐n)灏�(d菐o)鍒嗗瓙鑸囪棩鐗�銆�
锛堝叓锛夎倽鑷熺殑鐢熺墿鍖栧(xu茅)
1.鑲濈殑鐢熺墿杞�(zhu菐n)鍖栦綔鐢細鑲濈殑鐢熺墿杞�(zhu菐n)鍖栦綔鐢ㄦ槸姗�(j墨)楂旈噸瑕佺殑淇濊(h霉)姗�(j墨)鍒�锛�
鑲濈殑鐢熺墿杞�(zhu菐n)鍖栧弽鎳�(y墨ng)椤炲瀷鍙婇叾绯�锛涜倽鐨勭敓鐗╄綁(zhu菐n)鍖栦綔鐢ㄥ彈瑷卞鍥犵礌鐨勮(di脿o)
绡€(ji茅)鍜屽奖闊裤€�
2.鑶芥眮閰哥殑浠ｈ瑵锛氳喗姹侀吀鐨勫垎椤�锛涜喗姹侀吀鐨勪唬璎�锛涜喗姹侀吀鐨勭敓鐞嗗姛
鑳�銆�
3.鑶借壊绱犱唬璎濊垏榛冪柛锛氳喗绱呯礌鐨勪締婧愯垏鐢熸垚锛涜喗绱呯礌鍦ㄨ娑蹭腑鐨勯亱(y霉n)
杓�锛涜喗绱呯礌鍦ㄨ倽涓殑杞�(zhu菐n)璁�锛涜喗绱呯礌鍦ㄨ吀閬撳収(n猫i)鐨勮綁(zhu菐n)璁婅垏鑶界礌鍘熺殑鑵歌倽
寰挵(hu谩n)锛涢珮鑶界磪绱犺鐧ュ強榛冪柛锛涜喗绱呯礌鍙婃哀鍖栦慨椋句綆瀵嗗害鑴傝泲鐧�
锛坥x-LDL锛夎垏鍐犲績鐥呯殑闂�(gu膩n)绯汇€�
涓�銆佸垎瀛愮敓鐗╁(xu茅)
锛堜竴锛夋牳閰哥殑绲�(ji茅)妲�(g貌u)鑸囧姛鑳�
1.鏍搁吀鐨勫熀鏈祫鎴愬柈浣嶁€旀牳鑻烽吀锛氬牽鍩�锛涙垔绯栵紱鏍歌嫹锛涙牳鑻烽吀锛涙牳
閰�銆�
2.DNA 鐨勭祼(ji茅)妲�(g貌u)鑸囧姛鑳斤細DNA 鐨勪竴绱氱祼(ji茅)妲�(g貌u)锛汥NA 鐨勪簩绱氱祼(ji茅)妲�(g貌u)锛汥NA 鐨勯珮
绱氱祼(ji茅)妲�(g貌u)锛汥NA 鐨勫姛鑳�銆�
3.RNA 鐨勭祼(ji茅)妲�(g貌u)鍜屽姛鑳斤細鍙冭垏铔嬬櫧璩�(zh矛)鐢熺墿鍚堟垚鐨� 3 椤� RNA锛涘叾浠栭潪绶�
纰� RNA 鐨勭祼(ji茅)妲�(g貌u)鑸囧姛鑳�銆�
4.鏍搁吀鐨勭悊鍖栨€ц唱(zh矛)锛氭牳閰哥殑绱鍚告敹鐗规€�锛涙牳閰哥殑璁婃€с€佸京(f霉)鎬ц垏鍒�
瀛愰洔浜�锛涙牳閰哥殑鍒嗛洟鑸囩磾鍖�锛涙牳閰哥殑搴忓垪鍒嗘瀽銆�
锛堜簩锛夋牳鑻烽吀浠ｈ瑵
1.鏍搁吀鐨勬秷鍖栬垏鍚告敹
2.鍢屽懁鏍歌嫹閰镐唬璎濓細鍢屽懁鏍歌嫹閰哥殑鍚堟垚浠ｈ瑵锛涙牳鑻烽吀鐨勫垎瑙ｄ唬璎�锛�
鍢屽懁鏍歌嫹閰镐唬璎濊垏鐤剧梾銆�
3.鍢у暥鏍歌嫹閰镐唬璎濓細鍢у暥鏍歌嫹閰哥殑鍚堟垚浠ｈ瑵锛涘槯鍟舵牳鑻烽吀鐨勫垎瑙ｄ唬
璎�锛涘槯鍟舵牳鑻烽吀浠ｈ瑵鑸囩柧鐥呫€�
锛堜笁锛塂NA 鐨勭敓鐗╁悎鎴�
1.DNA 寰�(f霉)鍒剁殑鍩烘湰瑕�(gu墨)寰嬶細DNA 鐨勫崐淇濈暀寰�(f霉)鍒�锛汥NA 鐨勫崐涓嶉€ｇ簩(x霉)寰�(f霉)鍒讹紱
DNA 鐨勯洐鍚戝京(f霉)鍒�銆�
2.鍘熸牳鐢熺墿 DNA 寰�(f霉)鍒讹細鍘熸牳鐢熺墿寰�(f霉)鍒剁殑璧峰锛涘師鏍哥敓鐗╁京(f霉)鍒剁殑寤堕暦锛�
鍘熸牳鐢熺墿寰�(f霉)鍒剁殑绲傛銆�
3.鐪熸牳绱�(x矛)鑳� DNA 鐢熺墿鍚堟垚閬庣▼锛氱湡鏍哥敓鐗╁京(f霉)鍒剁殑璧峰锛涚湡鏍哥敓鐗╁京(f霉)
鍒剁殑寤堕暦锛涚湡鏍哥敓鐗╁京(f霉)鍒剁殑绲傛銆傜绮掔殑绲�(ji茅)妲�(g貌u)浠ュ強绔矑閰� DNA 鐨勫悎
鎴�锛涚湡鏍哥敓鐗╁京(f霉)鍒剁殑瑾�(di脿o)鎺ф(j墨)鍒躲€�
4.閫嗚綁(zhu菐n)閷勫拰鍏朵粬寰�(f霉)鍒舵柟寮忥細閫嗚綁(zhu菐n)閷勫京(f霉)鍒舵(j墨)鍒�锛汥-鐠�(hu谩n)寰�(f霉)鍒舵(j墨)鍒�锛涙痪鐠�(hu谩n)
寰�(f霉)鍒舵(j墨)鍒躲€�
5.DNA 鎼嶅偡鑸囦慨寰�(f霉)锛欴NA 鎼嶅偡椤炲瀷锛汥NA 淇京(f霉)鏂瑰紡锛涙悕鍌疯垏淇京(f霉)鐨�
鐢熺悊鎰忕京銆�
锛堝洓锛塕NA 鐨勭敓鐗╁悎鎴�
1.RNA 鍚堟垚姒傝堪锛歊NA 鍚堟垚鏂瑰紡锛涜綁(zhu菐n)閷勬ā鐗堣垏鑱氬悎閰�銆�
2.鍘熸牳鐢熺墿鐨勮綁(zhu菐n)閷勯亷绋嬶細鍘熸牳鐢熺墿杞�(zhu菐n)閷勭殑璧峰锛涘師鏍哥敓鐗╄綁(zhu菐n)閷勭殑寤�
闀凤紱鍘熸牳鐢熺墿杞�(zhu菐n)閷勭殑绲傛銆�
3.鐪熸牳鐢熺墿 RNA 鐨勭敓鐗╁悎鎴愶細鐪熸牳鐢熺墿杞�(zhu菐n)閷勭殑璧峰锛涚湡鏍哥敓鐗╄綁(zhu菐n)閷�
鐨勫欢闀凤紱鐪熸牳鐢熺墿杞�(zhu菐n)閷勭殑绲傛銆�
4.鐪熸牳鐢熺墿鐨勮綁(zhu菐n)閷勫悗鍔犲伐锛歮RNA 鐨勮綁(zhu菐n)閷勫悗鍔犲伐锛況RNA 鐨勮綁(zhu菐n)閷勫悗鍔�
宸�锛泃RNA 鐨勮綁(zhu菐n)閷勫悗鍔犲伐銆�
5.寰� RNA 鐨勭敓鐗╁悎鎴愶細寰� RNA 鐨勭祼(ji茅)妲�(g貌u)鐗归粸(di菐n)鑸囧姛鑳斤紱寰� RNA 鐨勭敓鐗╁悎
鎴�銆�
锛堜簲锛夎泲鐧借唱(zh矛)鐨勭敓鐗╁悎鎴�
1.铔嬬櫧璩�(zh矛)鐨勭敓鐗╁悎鎴愰珨绯伙細閬哄偝瀵嗙⒓鐨勨€滄敎甯惰€呪€�-mRNA锛涙皑鍩洪吀
鐨勨€滄惉閬�(y霉n)宸ュ叿鈥�-tRNA锛涜偨閺堢殑鈥滆閰嶆(j墨)鈥�-鏍哥硸楂旓紱鑲介張鐢熺墿鍚堟垚
闇€瑕佺殑閰堕鍜岃泲鐧借唱(zh矛)鍥犲瓙銆�
2.铔嬬櫧璩�(zh矛)鐨勭敓鐗╁悎鎴愰亷绋嬶細姘ㄥ熀閰哥殑娲诲寲鑸囨惉閬�(y霉n)锛涜偨閺堝悎鎴愮殑璧峰锛�
鑲介張鍚堟垚鐨勫欢闀�锛涜偨閺堝悎鎴愮殑绲傛锛涘鏍哥硸楂�銆�
3.铔嬬櫧璩�(zh矛)鐨勬垚鐔燂細澶氳偨閺堢殑鎶樼枈锛涜泲鐧借唱(zh矛)鐨勭炕璀悗淇＞锛涜泲鐧借唱(zh矛)鍚�
鎴愬悗鐨勯澏鍚戣几閫併€�
4.铔嬬櫧璩�(zh矛)鐢熺墿鍚堟垚鐨勫共鎿捐垏鎶戝埗锛氭姉鐢熺礌椤為樆鏂峰姂锛涘共鎿捐泲鐧借唱(zh矛)鐢�
鐗╁悎鎴愮殑鐢熺墿娲绘€х墿璩�(zh矛)銆�
锛堝叚锛夊熀鍥犺〃閬�(d谩)瑾�(di脿o)鎺�
1.鍩哄洜琛ㄩ仈(d谩)鑸囧熀鍥犺〃閬�(d谩)瑾�(di脿o)鎺э細鍩哄洜琛ㄩ仈(d谩)鍙婂叾鐗归粸(di菐n)锛涘熀鍥犺〃閬�(d谩)瑾�(di脿o)鎺�銆�
2.鍘熸牳鍩哄洜琛ㄩ仈(d谩)瑾�(di脿o)鎺э細鍘熸牳鍩哄洜杞�(zhu菐n)閷勮(di脿o)绡€(ji茅)鐗归粸(di菐n)锛涗钩绯栨搷绺卞瓙瑾�(di脿o)绡€(ji茅)姗�(j墨)
鍒�锛涘叾浠栬綁(zhu菐n)閷勮(di脿o)绡€(ji茅)姗�(j墨)鍒�銆�
3.鐪熸牳鍩哄洜琛ㄩ仈(d谩)瑾�(di脿o)鎺э細鐪熸牳鍩哄洜鐨勭祼(ji茅)妲�(g貌u)鐗归粸(di菐n)锛涙煋鑹茶唱(zh矛)鐨勬椿鍖�锛涜綁(zhu菐n)閷�
璧峰鐨勮(di脿o)鎺�锛涘叾浠栨按骞崇殑瑾�(di脿o)鎺�銆�
(涓�)閲嶇祫 DNA 鑸囬噸绲� DNA 鎶€琛�(sh霉)
1.鑷劧鐣� DNA 閲嶇祫鐨勬柟寮忥細鍚屾簮閲嶇祫锛涗綅榛�(di菐n)鐗圭暟鎬ч噸绲�锛涜綁(zhu菐n)搴ч噸绲勶紱
鍘熸牳绱�(x矛)鑳炵殑澶氱ó鍩哄洜杞�(zhu菐n)绉绘柟寮�銆�
2.閲嶇祫 DNA 鎶€琛�(sh霉)锛氬熀鏈蹇靛拰鍘熺悊锛涘父鐢ㄥ伐鍏烽叾锛涘父鐢ㄨ級楂�锛涢噸绲�
DNA 鐨勬(g貌u)寤哄拰绡╅伕銆�
3.閲嶇祫 DNA 鎶€琛�(sh霉)鍦ㄩ啱(y墨)瀛�(xu茅)涓殑鎳�(y墨ng)鐢細鍩哄洜宸ョ▼钘ョ墿鍙婄柅鑻楃殑鐮斿埗锛涘熀
鍥犺ê鏂�锛涘熀鍥犳不鐧�銆�
4.鍩哄洜绲勫(xu茅)鑸囪綁(zhu菐n)閷勭祫瀛�(xu茅)锛氱祼(ji茅)妲�(g貌u)鍩哄洜绲勫(xu茅)鑸囧姛鑳藉熀鍥犵祫瀛�(xu茅)銆佸井闄ｅ垪銆�
鍩哄洜琛ㄩ仈(d谩)绯诲垪鍒嗘瀽銆佸ぇ瑕�(gu墨)妯″钩琛屼俊铏熸脯搴忕郴绲�(t菕ng)銆�
鍥�銆侀伜鍌冲(xu茅)锛堥啱(y墨)瀛�(xu茅)锛�
锛堜竴锛夌窉璜�
1.閱�(y墨)瀛�(xu茅)閬哄偝瀛�(xu茅)姒傝堪锛氭蹇点€佷换鍕�(w霉)銆佽寖鐤囧拰鐧�(f膩)灞曞彶
2.閬哄偝鐥呮杩帮細鐗归粸(di菐n)銆佸垎椤�銆佸(sh铆)韪愭噳(y墨ng)鐢ㄥ拰娑夊強鐨勫€悊鍟忛
3.閬哄偝鐥呯殑鐮旂┒绛栫暐锛氶伜鍌崇梾鐨勭梾鐞嗐€佽ê鏂�銆佹不鐧傚拰闋�(y霉)闃�
锛堜簩锛夊熀鍥犵獊璁�
1.瑾樼櫦(f膩)鍩哄洜绐佽畩鐨勫洜绱狅細鐗╃悊鍥犵礌銆佸寲瀛�(xu茅)鍥犵礌鍜岀敓鐗╁(xu茅)鍥犵礌
2.鍩哄洜绐佽畩鐨勪竴鑸壒鎬э細澶氬悜鎬с€佸彲閫嗘€с€佹湁瀹虫€�銆佺█鏈夋€�銆侀毃姗�(j墨)
鎬у拰鍙噸寰�(f霉)鎬�
3.鍩哄洜绐佽畩鐨勫垎瀛愭(j墨)鍒讹細闈滄厠(t脿i)绐佽畩鍜屽嫊鎱�(t脿i)绐佽畩
4.DNA 鎼嶅偡鐨勪慨寰�(f霉)锛氱传澶栫窔鍜岄浕闆㈣蓟灏勫紩璧风殑 DNA 鎼嶅偡鐨勪慨寰�(f霉)锛涗慨
寰�(f霉)缂洪櫡寮曡捣鐨勭柧鐥�
锛堜笁锛夌獊璁婂熀鍥犵殑鍒嗗瓙绱�(x矛)鑳炵敓鐗╁(xu茅)鏁堟噳(y墨ng)
1.鍩哄洜绐佽畩灏�(d菐o)鑷磋泲鐧借唱(zh矛)鍔熻兘鏀硅畩锛氱獊璁婂皪铔嬬櫧璩�(zh矛)鐢熺墿鍚堟垚銆佸姛鑳芥晥
鎳�(y墨ng)鍜岀窗(x矛)鑳炲畾浣嶇殑褰遍熆锛涚獊璁婅泲鐧借垏鐥呰畩閮ㄤ綅銆佽嚚搴婅〃鍨嬮枔鐨勯棞(gu膩n)绯�
2.鍩哄洜绐佽畩寮曡捣鎬х媭鏀硅畩鐨勭窗(x矛)鑳炵敓鐗╁(xu茅)姗�(j墨)鍒讹細閰惰泲鐧藉垎瀛愬拰闈為叾铔�
鐧藉垎瀛愮殑缂洪櫡
锛堝洓锛夊柈鍩哄洜鐤剧梾鐨勯伜鍌�
1.绯昏瓬鑸囩郴璀滃垎鏋愭硶锛氱郴璀滃強甯哥敤绻埗绗﹁櫉
2.甯告煋鑹查珨椤€�銆侀毐鎬ч伜鍌崇梾鐨勯伜鍌筹細浠ｈ〃鎬х柧鐥�銆侀伜鍌崇壒寰佸拰瀛�
浠ｇ櫦(f膩)鐥呴ⅷ(f膿ng)闅�(xi菐n)
3.X 閫ｉ帠椤€�銆侀毐鎬ч伜鍌崇梾鐨勯伜鍌筹細浠ｈ〃鎬х柧鐥�銆侀伜鍌崇壒寰佸拰瀛愪唬
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锛堜竷锛夊鍩哄洜閬哄偝鐥�
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锛堝叓锛夌窔绮掗珨閬哄偝
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鍜� mtDNA 鐨勫京(f霉)鍒�
2.绶氱矑楂斿熀鍥犵殑绐佽畩锛氱獊璁婄巼銆佺獊璁婇鍨嬪拰绐佽畩鐨勪慨寰�(f霉)
3.绶氱矑楂旈伜鍌崇殑鐗归粸(di菐n)锛氭瘝鎬ч伜鍌炽€佺暟璩�(zh矛)鎬�銆侀柧鍊兼晥鎳�(y墨ng)鍜屼笉鍧囩瓑鐨勬湁
绲插垎瑁傚垎闆�
锛堜節锛夌窔绮掗珨鐤剧梾
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锛堝崄锛変汉椤炴煋鑹查珨
1.浜洪鏌撹壊楂旂殑鍩烘湰鐗瑰緛锛氭煋鑹茶唱(zh矛)銆佸父鏌撹壊楂斿拰鎬ф煋鑹查珨
2.鏌撹壊楂斿垎绲勩€佹牳鍨嬭垏椤付鎶€琛�(sh霉)锛氱爺绌舵柟娉�銆佸付鍨嬪拰鍦嬮殯鍛藉悕楂斿埗
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锛堝崄浜岋級鐣歌畩?n猫i)鏃ь偘w寮曡捣鐨勭柧鐥�
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甯惰€�
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1.鑵槫鐧�(f膩)鐢熺殑閬哄偝鐝�(xi脿n)璞★細鍠熀鍥犻伜鍌冲拰澶氬熀鍥犻伜鍌崇殑鑵槫锛涙煋鑹查珨
鐣歌畩鑸囪叓鐦ょ櫦(f膩)鐢熺殑闂�(gu膩n)绯�锛涙槗鎮ｈ叓鐦ょ殑鍌惧悜鎬�
2.鑵槫鍩哄洜锛氳叓鐦ゆ姂鍒跺熀鍥�銆佽叓鐦ょ檶鍩哄洜鍜屽弮鑸� DNA 淇京(f霉)鐨勫熀鍥�
3.鑵槫鐨勫姝ラ鐧�(f膩)鐢熷拰鐧屽熀鍥犵祫瑙ｅ墫瑷�(j矛)鍔�
锛堝崄鍥涳級鍑虹敓缂洪櫡
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锛堝崄浜旓級琛ㄨ閬哄偝鑸囩柧鐥�
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锛堝崄鍏級閬哄偝鐥呯殑瑷烘柗鑸囨不鐧�
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1.绱�(x矛)鑳炵殑鍩烘湰鐗瑰緛锛氭蹇靛拰鍒嗛锛屽師鏍哥窗(x矛)鑳�锛岀湡鏍哥窗(x矛)鑳烇紝鐥呮瘨锛岀窗(x矛)
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锛堜笁锛夌窗(x矛)鑳炶啘
1.绱�(x矛)鑳炶啘鐨勫寲瀛�(xu茅)绲勬垚锛氳剛璩�(zh矛)锛岃泲鐧借唱(zh矛)锛岀硸椤烇紝
2.绱�(x矛)鑳炶啘鐨勫垎瀛愮祼(ji茅)妲�(g貌u)锛氳啘鑴傚垎瀛愮殑鎺掑垪锛岀窗(x矛)鑳炶啘鐨勭祼(ji茅)妲�(g貌u)妯″瀷
3.绱�(x矛)鑳炶啘鐨勭敓鐗╁(xu茅)鐗规€э細涓嶅皪绋辨€э紝娴佸嫊鎬�锛�
锛堝洓锛夊収(n猫i)鑶滅郴绲�(t菕ng)
1.鍏�(n猫i)璩�(zh矛)缍�(w菐ng)锛氱祼(ji茅)妲�(g貌u)锛岀硻闈㈠収(n猫i)璩�(zh矛)缍�(w菐ng)锛屽厜闈㈠収(n猫i)璩�(zh矛)缍�(w菐ng)锛屽井绮掗珨
2.楂樼埦鍩哄京(f霉)鍚堥珨锛氬舰鎱�(t脿i)锛屾暩(sh霉)鐩拰鍒嗗竷
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5.鍥婃场锛氱祫鎴�锛屽垎椤炲拰鍔熻兘
锛堜簲锛夌窔绮掗珨
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2.绶氱矑楂旂殑鍖栧(xu茅)绲勬垚锛氳泲鐧借唱(zh矛)锛岃剛椤烇紝閰剁郴
3.绶氱矑楂旂殑閬哄偝楂旂郴锛氱窔绮掗珨 DNA锛岀窔绮掗珨鍩哄洜鐨勮綁(zhu菐n)閷勫拰寰�(f霉)鍒�锛岀窔
绮掗珨閬哄偝鐗归粸(di菐n)
4.绶氱矑楂旀牳绶ㄧ⒓铔嬬櫧鐨勮綁(zhu菐n)閬�(y霉n)锛氭牳绶ㄧ⒓铔嬬櫧鍚戠窔绮掗珨鍩鸿唱(zh矛)锛岃啘闁撹厰锛�
澶栬啘鍜屽収(n猫i)鑶滅殑杞�(zhu菐n)閬�(y霉n)锛�
5.绶氱矑楂旂殑璧锋簮锛氬収(n猫i)鍏辩敓瀛�(xu茅)瑾�锛岄潪鍏辩敓鍋囪
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7.绶氱矑楂旂殑鍔熻兘锛氳(di脿o)绡€(ji茅)绱�(x矛)鑳炲収(n猫i)鐨勯洟瀛愬钩琛�锛岃垏绱�(x矛)鑳炲噵浜¤伅(li谩n)绯伙紝鑳介噺
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8.绶氱矑楂旈啱(y墨)瀛�(xu茅)锛氱柧鐥呬腑绶氱矑楂旇畩鍖�锛岀窔绮掗珨 DNA 绐佽畩鑸囩柧鐥�锛岀窔绮�
楂旇瀺鍚堬紝鍒嗚鐣板父鐩搁棞(gu膩n)鐤剧梾
锛堝叚锛夌窗(x矛)鑳為鏋�
1.寰锛氱祼(ji茅)妲�(g貌u)鍜屽寲瀛�(xu茅)绲勬垚锛岄鍨嬶紝绲勮鍜屾サ鎬�锛岀簴姣涳紝闉瘺锛屼腑鎬�
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2.寰挡锛氱祼(ji茅)妲�(g貌u)锛岀祫鎴愬拰绲勮
3.涓枔绲诧細涓枔绲茬殑铔嬬櫧鍒嗛锛屽垎瀛愮祼(ji茅)妲�(g貌u)鍜岀祫瑁�
锛堜竷锛夌窗(x矛)鑳炴牳
1.鏍歌啘锛氶洐灞よ啘鑸囨牳鍛ㄩ枔闅�锛屾牳瀛斿京(f霉)鍚堥珨锛屾牳绾栧堡
2.鏌撹壊璩�(zh矛)锛氬寲瀛�(xu茅)绲勬垚锛岀祼(ji茅)妲�(g貌u)锛岀祫瑁�锛屾煋鑹查珨澶氱礆铻烘棆妯″瀷锛屾煋鑹查珨
鏀灦-鏀惧皠鐠�(hu谩n)绲�(ji茅)妲�(g貌u)妯″瀷锛屽父鏌撹壊璩�(zh矛)锛岀暟鏌撹壊璩�(zh矛)
3.鏌撹壊楂旓細涓湡鏌撹壊楂旂殑绲�(ji茅)妲�(g貌u)锛屾牳鍨�
4.鏍镐粊锛氬寲瀛�(xu茅)绲勬垚锛屼簽椤井绲�(ji茅)妲�(g貌u)锛屾牳浠佸懆鏈�
5.鏍稿熀璩�(zh矛)锛氭牳楠ㄦ灦鐨勭祫鎴�锛屾牳楠ㄦ灦鐨勫姛鑳�
锛堝叓锛夌窗(x矛)鑳炲鍩鸿唱(zh矛)
1.绱�(x矛)鑳炲鍩鸿唱(zh矛)鐨勪富瑕佺祫鍒嗭細铔嬬櫧鑱氱硸锛岃啝鍘�锛屽綀鎬ц泲鐧斤紝绾栫矘閫ｈ泲
鐧�锛屽堡绮橀€ｈ泲鐧斤紝
2.鍩鸿啘锛氱祫鎴愯垏绲勮
3.绱�(x矛)鑳炲鍩鸿唱(zh矛)鐨勭敓鐗╁(xu茅)浣滅敤锛氱窗(x矛)鑳炲鍩鸿唱(zh矛)鐨勪綔鐢�锛岀窗(x矛)鑳炲鍩鸿唱(zh矛)鑸囩柧
鐥呯殑鑱�(li谩n)绯�
锛堜節锛夌窗(x矛)鑳炵殑鐗╄唱(zh矛)閬�(y霉n)杓�
1.闆㈠瓙鍜屽皬鍒嗗瓙鐨勮法鑶滈亱(y霉n)杓革細鍠磾鎿�(ku貌)鏁�锛岄€氶亾鎿�(ku貌)鏁�锛屽公鍔╂摯(ku貌)鏁ｏ紝闆�
瀛愭车锛屼即闅ㄩ亱(y霉n)杓�锛�
2.鐢熺墿澶у垎瀛愬拰椤嗙矑鐨勮法鑶滆綁(zhu菐n)閬�(y霉n)锛氳優椋蹭綔鐢�锛屽悶鍣綔鐢�锛屽彈楂斾粙灏�(d菐o)
鐨勮優鍚炰綔鐢�锛岃優鍚愪綔鐢�锛�
3.绱�(x矛)鑳炲収(n猫i)铔嬬櫧璩�(zh矛)鐨勮綁(zhu菐n)閬�(y霉n)锛氱窗(x矛)鑳炲収(n猫i)铔嬬櫧璩�(zh矛)閬�(y霉n)杓�?sh霉)鑰愮珐鍓戭儣?x矛)鑳炲収(n猫i)铔嬬櫧璩�(zh矛)
鐨勯亱(y霉n)杓告柟寮�锛屽垎閬镐俊铏�锛屽垎瀛愪即渚讹紝闁€鎺ц綁(zhu菐n)閬�(y霉n)锛岀┛鑶滆綁(zhu菐n)閬�(y霉n)锛岃啘鎬х窗(x矛)
鑳炲櫒闁撶殑鍥婃场杞�(zhu菐n)閬�(y霉n)
4.绱�(x矛)鑳炲収(n猫i)铔嬬櫧璩�(zh矛)鐨勫姞宸ュ拰鍒嗘硨锛氳泲鐧借唱(zh矛)鍦ㄥ収(n猫i)璩�(zh矛)缍�(w菐ng)鍜岄珮鐖惧熀楂斾腑鐨勭硸
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5.绱�(x矛)鑳炵墿璩�(zh矛)閬�(y霉n)杓歌垏閱�(y墨)瀛�(xu茅)锛氱窗(x矛)鑳炵墿璩�(zh矛)閬�(y霉n)杓哥己闄疯垏鐤剧梾鐨勮伅(li谩n)绯�
锛堝崄锛変俊铏熻綁(zhu菐n)灏�(d菐o)
1.鑳炲淇¤櫉锛氬収(n猫i)鍒嗘硨锛屾梺鍒嗘硨锛岃嚜鍒嗘硨锛岃繎鍒嗘硨
2.鍙楅珨锛氬彈楂旂殑鍩烘湰姒傚康锛岃啘鍙楅珨鐨勭祼(ji茅)妲�(g貌u)鍜岄鍨�锛岃啘鍙楅珨鐨勭壒榛�(di菐n)锛�
鑶滃彈楂旂殑鏁�(sh霉)閲忓拰鍒嗗竷锛屽彈楂旂殑婵€鍕曞姂鍜屾嫯鎶楀姂锛岀窗(x矛)鑳炲収(n猫i)鍙楅珨
3.绱�(x矛)鑳炰俊铏熻綁(zhu菐n)灏�(d菐o)涓殑闂�(gu膩n)閸佃泲鐧斤細铔嬬櫧婵€閰�锛岃泲鐧界７閰搁叾锛岄姕鎺ヨ泲鐧�锛�
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4.绗簩淇′娇鍙婂叾浠嬪皫(d菐o)鐨勪俊铏熼€氳矾锛歝AMP 淇¤櫉閫氳矾锛岀７鑴傞叞鑲岄唶淇�
铏熼€氳矾锛宑GMP 淇¤櫉閫氳矾
5.鍙楅珨閰皑閰告縺閰朵粙灏�(d菐o)鐨勪俊铏熼€氳矾锛歊as-MAPK 淇¤櫉閫氳矾锛孭I3K-AKT
淇¤櫉閫氳矾
6.绱�(x矛)鑳炲洜瀛愬彈楂斾粙灏�(d菐o)鐨勪俊铏熼€氳矾锛欽AK-STAT 淇¤櫉閫氳矾鍙婂叾鑸囪叓鐦�
鑱�(li谩n)绯�
7.铔嬬櫧姘磋В鐩搁棞(gu膩n)鐨勪俊铏熼€氳矾锛歂F-kB 淇¤櫉閫氳矾锛孨otch-Delta 淇¤櫉
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8.绱�(x矛)鑳炰俊铏熻綁(zhu菐n)灏�(d菐o)鐨勭壒榛�(di菐n)锛氱７閰稿寲鍜屽幓纾烽吀鍖�锛岀礆鑱�(li谩n)鍙嶆噳(y墨ng)锛屼氦鍙夊皪瑭�
锛堝崄涓€锛夌窗(x矛)鑳為亱(y霉n)鍕�
1.绱�(x矛)鑳為亱(y霉n)鍕曠殑褰㈠紡锛氱窗(x矛)鑳炰綅缃Щ鍕�锛岀窗(x矛)鑳炲舰鎱�(t脿i)鏀硅畩锛岀窗(x矛)鑳炲収(n猫i)閬�(y霉n)鍕�
2.绱�(x矛)鑳為亱(y霉n)鍕曠殑姗�(j墨)鍒跺拰瀵�(sh铆)渚嬶細棣仈(d谩)铔嬬櫧鐨勭祫鎴愬拰姗�(j墨)鍒讹紝绾栨瘺鍜岄灜姣涚殑
閬�(y霉n)鍕曟(j墨)鍒�锛屽井绲插拰寰绲勮寮曡捣鐨勭窗(x矛)鑳為亱(y霉n)鍕曪紝鏌撹壊楂斿垎闆�锛岃倢鑲夋敹
绺紝鎴愮簴缍窗(x矛)鑳炵殑閬�(y霉n)鍕�锛岀櫧绱�(x矛)鑳為亱(y霉n)鍕�
3.绱�(x矛)鑳為亱(y霉n)鍕曠殑瑾�(di脿o)绡€(ji茅)锛欸 铔嬬櫧浣滅敤锛岀窗(x矛)鑳炲鍒嗗瓙鐨勮定鍖栦綔鐢�锛孋a2+婵�
搴︽搴︼紝褰遍熆绱�(x矛)鑳為鏋惰垏閬�(y霉n)鍕曠殑钘ョ墿
4.绱�(x矛)鑳為亱(y霉n)鍕曡垏閱�(y墨)瀛�(xu茅)锛氱窗(x矛)鑳為亱(y霉n)鍕曡垏鐤剧梾鐨勮伅(li谩n)绯�
锛堝崄浜岋級绱�(x矛)鑳炲娈�
1.绱�(x矛)鑳炲娈栧懆鏈熸杩帮細绱�(x矛)鑳炲懆鏈熺殑瀹氱京鍜屽垎鏈�
2.绱�(x矛)鑳炲懆鏈熷悇鏈熺殑涓昏鐗瑰緛锛欸1锛孲锛孏2锛孧 鏈熺殑涓昏鐗瑰緛锛�
3.绱�(x矛)鑳炲娈栫殑瑾�(di脿o)鎺у洜绱狅細鐢熼暦鍥犲瓙鐨勮(di脿o)鎺т綔鐢紝鍛ㄦ湡铔嬬櫧渚濊炒鎬ф縺
閰跺拰绱�(x矛)鑳炲懆鏈熻泲鐧界殑鐩镐簰浣滅敤锛岀窗(x矛)鑳炲懆鏈熸鏌ラ粸(di菐n)
4.娓涙暩(sh霉)鍒嗚鍜岀敓娈栫窗(x矛)鑳炵殑鐧�(f膩)鐢燂細娓涙暩(sh霉)鍒嗚閬庣▼锛岀敓娈栫窗(x矛)鑳炵殑鐧�(f膩)鐢�锛�
娓涙暩(sh霉)鍒嗚鐨勭敓鐗╁(xu茅)鎰忕京
5.绱�(x矛)鑳炲懆鏈熻垏鑵槫锛氱窗(x矛)鑳炲懆鏈熷熀鍥犲け瑾�(di脿o)鑸囪叓鐦ょ殑鑱�(li谩n)绯�
锛堝崄涓夛級绱�(x矛)鑳炲垎鍖�
1.绱�(x矛)鑳炲垎鍖栫殑鍩烘湰姒傚康锛氱窗(x矛)鑳炵殑姹哄畾鍜屽垎鍖�锛屽绱�(x矛)鑳炵敓鐗╃殑绱�(x矛)鑳炲垎
鍖�
2.绱�(x矛)鑳炵殑鍒嗗寲娼涜兘锛氬叏鑳界窗(x矛)鑳炵殑鍒嗗寲娼涜兘锛岃儦鑳庣窗(x矛)鑳炵殑鍒嗗寲娼涜兘锛�
鎴愰珨绱�(x矛)鑳炵殑鍒嗗寲娼涜兘
3.绱�(x矛)鑳炲垎鍖栫殑鍒嗗瓙鍩虹(ch菙)锛氱窗(x矛)鑳炲垎鍖栫殑鏈唱(zh矛)鍜岃(di脿o)鎺�锛屽ア渚堝熀鍥狅紝绠″
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4.绱�(x矛)鑳炲垎鍖栬垏鑵槫锛氳叓鐦ょ窗(x矛)鑳炵殑澧炴畺鐗归粸(di菐n)锛岃叓鐦ょ窗(x矛)鑳炵殑鍒嗗寲锛岀檶绱�(x矛)
鑳炵殑閫嗚綁(zhu菐n)
5.骞茬窗(x矛)鑳烇細骞茬窗(x矛)鑳炵殑鐗归粸(di菐n)锛屽共绱�(x矛)鑳炲井鐠�(hu谩n)澧冿紝鑳氳儙骞茬窗(x矛)鑳�锛屾垚楂斿共绱�(x矛)
鑳�锛岃獦灏�(d菐o)澶氳兘骞茬窗(x矛)鑳�
锛堝崄鍥涳級绱�(x矛)鑳炶“鑰�
1.绱�(x矛)鑳炶“鑰侊細绱�(x矛)鑳炲＝鍛�锛岀窗(x矛)鑳炶“鑰佽〃鐝�(xi脿n)
2.绔矑锛岀绮掗叾鑸囩窗(x矛)鑳炶“鑰侊細绔矑锛岀绮掗叾鐨勭壒榛�(di菐n)
3.绱�(x矛)鑳炶“鑰佹(j墨)鍒讹細閬哄偝姹哄畾瑾�锛岃嚜鐢卞熀瀛�(xu茅)瑾紝绁炵稉(j墨ng)鍏�(n猫i)鍒嗘硨-鍏嶇柅瑾�(di脿o)
绡€(ji茅)瀛�(xu茅)瑾�锛屽叾瀹冪窗(x矛)鑳炶“鑰佸(xu茅)瑾�
锛堝崄浜旓級绱�(x矛)鑳炴浜�
1.绱�(x矛)鑳炲姝伙細绱�(x矛)鑳炲姝荤殑鐗归粸(di菐n)鍜屼俊铏熼€氳矾
2.绱�(x矛)鑳炲噵浜★細绱�(x矛)鑳炲噵浜＄殑鐢熺墿瀛�(xu茅)鍜岀梾鐞嗗(xu茅)鎰忕京锛岀窗(x矛)鑳炲噵浜＄殑褰㈡厠(t脿i)鍜�
鐢熷寲鐗瑰緛锛屽奖闊跨窗(x矛)鑳炲噵浜＄殑鍥犵礌锛岀窗(x矛)鑳炲噵浜′俊铏熼€氳矾锛岀窗(x矛)鑳炲噵浜¤垏
鐤剧梾鐨勮伅(li谩n)绯�
3.鑷櫖鎬х窗(x矛)鑳炴浜★細绱�(x矛)鑳炶嚜鍣殑鍒嗛锛屼俊铏熼€氳矾锛岃(di脿o)绡€(ji茅)姗�(j墨)鍒讹紝绱�(x矛)鑳�
鑷櫖鑸囩柧鐥呯殑鑱�(li谩n)绯�
鍏嶈铂(z茅)鑱叉槑锛氭湰鏂囩郴杞�(zhu菐n)杓夎嚜缍�(w菐ng)绲�(lu貌)锛屽鏈変镜鐘紝璜嬭伅(li谩n)绯绘垜鍊戠珛鍗冲埅闄�锛屽彟锛氭湰鏂囧儏浠ｈ〃浣滆€呭€嬩汉瑙€榛�(di菐n)锛岃垏鏈恫(w菐ng)绔欑劇闂�(gu膩n)銆傚叾鍘熷壍(chu脿ng)鎬т互鍙婃枃涓櫝杩版枃瀛楀拰鍏�(n猫i)瀹规湭缍�(j墨ng)鏈珯璀夊(sh铆)锛屽皪鏈枃浠ュ強鍏朵腑鍏ㄩ儴鎴栬€呴儴鍒嗗収(n猫i)瀹�銆佹枃瀛楃殑鐪熷(sh铆)鎬с€佸畬鏁存€�銆佸強鏅傛€ф湰绔欎笉浣滀换浣曚繚璀夋垨鎵胯锛岃珛璁€鑰呭儏浣滃弮鑰冿紝骞惰珛鑷鏍稿(sh铆)鐩搁棞(gu膩n)鍏�(n猫i)瀹�銆�
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