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鍙嬫儏鎻愮ず锛氭湰绔欐彁渚涘叏鍦�400澶氭墍楂樼瓑闄㈡牎鎷涙敹纰╁＋銆佸崥澹爺绌剁敓鍏ュ(xu茅)鑰冭│姝峰勾鑰冪爺鐪熼銆佽€冨崥鐪熼銆佺瓟妗堬紝閮ㄥ垎瀛�(xu茅)鏍℃洿鏂拌嚦2012骞�锛�2013骞�锛涘潎鎻愪緵鏀惰不(f猫i)涓嬭級銆� 涓嬭級娴佺▼锛� 鑰冪爺鐪熼 榛�(di菐n)鎿娾€�鑰冪爺瑭﹀嵎鈥濃€濅笅杓�; 鑰冨崥鐪熼 榛�(di菐n)鎿娾€�鑰冨崥瑭﹀嵎搴�鈥� 涓嬭級
1
鐩寗
I 鑰冩煡鐩(bi膩o)........................................................................................ 2
II 鑰冭│褰㈠紡鍜岃│鍗风祼(ji茅)妲�(g貌u) ..................................................................2
III 鑰冩煡鍏�(n猫i)瀹�..................................................................................... 2
IV. 椤屽瀷绀轰緥鍙婂弮鑰冪瓟妗�.................................................................5
2
鍏ㄥ湅纰╁＋鐮旂┒鐢熷叆瀛�(xu茅)绲�(t菕ng)涓€鑰冭│钘ュ(xu茅)缍滃悎涓€鑰冭│澶х侗
I 鑰冩煡鐩(bi膩o)
鐩殑鏄瀛�(xu茅)銆佸叕骞�銆佹湁鏁堝湴娓│鑰冪敓鏄惁鍏峰倷鏀昏畝钘ュ姂瀛�(xu茅)灏堟キ(y猫)鎵€蹇呴爤鐨勫熀鏈礌璩�(zh矛)銆佷竴鑸�
鑳藉姏鍜屽煿椁�(y菐ng)娼涜兘锛屼互鍒╃敤閬告嫈鍏锋湁鐧�(f膩)灞�?ji茅)鎽课﹁啲?y艒u)绉€浜烘墠鍏ュ(xu茅)锛岀偤鍦嬪閱�(y墨)钘ヤ簨妤�(y猫)鍩归(y菐ng)鍏锋湁鑹ソ
鑱锋キ(y猫)閬撳痉銆佸皥妤�(y猫)鐭ヨ瓨(sh铆)鍙婃妧鑳�銆佸叿鏈夎純寮�(qi谩ng)鍒嗘瀽鑸囪В姹哄(sh铆)闅涘晱椤岃兘鍔涘強鍓�(chu脿ng)鏂扮簿绁炵殑楂樺堡娆°€佹噳(y墨ng)鐢�
寰�(f霉)鍚堝瀷钘ュ(xu茅)灏堟キ(y猫)浜烘墠?锛熻崥鍥堫€︾鑿瑭﹁€冪敓鎺屾彙鍩烘湰鐞嗚珫鍙婂叾鎳�(y墨ng)鐢�銆佽檿鐞嗗拰鍒嗘瀽鍟忛鐨勬柟娉�銆�
鍏烽珨瑕佹眰鑰冪敓锛�
1.鎺屾彙鐢熺墿钘ュ姂瀛�(xu茅)鑸囪棩鐗╁嫊(d貌ng)鍔涘(xu茅)鍩烘湰鐞嗚珫鐭ヨ瓨(sh铆)鍙婃暩(sh霉)鎿�(j霉)铏曠悊鐨勫熀鏈柟娉�銆�
2.鎺屾彙鑷ㄥ簥钘ョ墿鐩�(ji膩n)娓強钘ョ墿鍕�(d貌ng)鍔涘(xu茅)鍦ㄨ嚚搴婁腑鐨勬噳(y墨ng)鐢ㄣ€�
3.鎺屾彙涓タ钘ョ墿鍒跺姂鍒嗘瀽鐨勫熀鏈柟娉曞強鐝�(xi脿n)琛岃棩鍝佹(bi膩o)婧�(zh菙n)鐨勫熀鏈収(n猫i)瀹�銆�
4.鎺屾彙甯哥敤鍎€鍣ㄥ垎鏋愭柟娉曠殑鍩烘湰鍘熺悊銆佸剙鍣ㄦ(g貌u)閫�銆佺壒榛�(di菐n)鍙婂叾鍦ㄨ棩鐗╁垎鏋愪腑鐨勬噳(y墨ng)鐢ㄣ€�
II 鑰冭│褰㈠紡鍜岃│鍗风祼(ji茅)妲�(g貌u)
涓€銆佽│鍗锋豢鍒嗗強鑰冭│鏅�(sh铆)闁�
瑭﹀嵎婊垮垎鐐� 300 鍒嗭紝鑰冭│鏅�(sh铆)闁� 180 鍒嗛悩銆�
浜�銆佺瓟椤屾柟寮�
闁夊嵎銆佺瓎瑭�銆傚厑瑷变娇鐢ㄨ▓(j矛)绠楀櫒銆備絾涓嶅緱浣跨敤甯舵湁鍏紡鍜屾枃鏈瓨鍎�(ch菙)鍔熻兘鐨勮▓(j矛)绠楀櫒銆�
涓夈€佽│鍗峰収(n猫i)瀹硅垏椤屽瀷绲�(ji茅)妲�(g貌u)
鐢熺墿钘ュ姂瀛�(xu茅)鑸囪棩鐗╁嫊(d貌ng)鍔涘(xu茅) 150 鍒�
鍚嶈瑙ｉ噵锛�6 鍊�(g猫)锛屾瘡椤� 3 鍒�锛屽叡 18 鍒嗭級
濉┖锛�20 绌�锛屾瘡绌� 1 鍒�锛屽叡 20 鍒嗭級
鍠伕椤岋紙8 鍊�(g猫)锛屾瘡椤� 1 鍒�锛屽叡 8 鍒嗭級
澶氶伕椤岋紙6 鍊�(g猫)锛屾瘡椤� 1.5 鍒嗭紝鍏� 9 鍒嗭級
鍟忕瓟椤岋紙8 鍊�(g猫)锛屽墠 7 椤� 7 鍒�锛岀 8 椤� 12 鍒�锛屽叡 61 鍒嗭級
瑷�(j矛)绠楅锛�3 鍊�(g猫)锛屽叡 34 鍒嗭級
钘ョ墿鍒嗘瀽锛堝惈鍒嗘瀽鍖栧(xu茅)锛� 150 鍒�
鍚嶈瑙ｉ噵(8 鍊�(g猫)锛屾瘡椤� 3 鍒�锛屽叡 24 鍒�)
濉┖椤岋紙6 鍊�(g猫)锛屾瘡绌� 1.5 鍒�锛屽叡 30 鍒嗭級
鍠伕椤岋紙8 鍊�(g猫)锛屾瘡椤� 2 鍒�锛屽叡 16 鍒嗭級
澶氶伕椤岋紙10 鍊�(g猫)锛屾瘡椤� 2 鍒�锛屽叡 20 鍒嗭級
绨＄瓟椤岋紙6~8 鍊�(g猫)锛屽叡 50 鍒嗭級
瑷�(j矛)绠楅锛�1~2 鍊�(g猫)锛屽叡 10 鍒嗭級
锛堝亣濡傛瘡椤屽垎?j菒n)?sh霉)鏈夎畩鍖�锛岃畩鍖栬寖鍦嶄害涓嶅ぇ銆傦級
III 鑰冩煡鍏�(n猫i)瀹�
涓€銆� 鐢熺墿钘ュ姂瀛�(xu茅)鑸囪棩鐗╁嫊(d貌ng)鍔涘(xu茅)
1锛庣敓鐗╄棩鍔戝(xu茅)姒傝堪锛氱敓鐗╄棩鍔戝(xu茅)鐨勫畾缇�銆佺爺绌跺収(n猫i)瀹广€佸姂鍨嬪洜绱犺垏鐢熺墿鍥犵礌鐨勫惈缇�銆佺敓
鐗╄棩鍔戝(xu茅)鐮旂┒鍦ㄦ柊钘ラ枊鐧�(f膩)涓殑浣滅敤銆�
2锛庡彛鏈嶈棩鐗╃殑鍚告敹锛氳棩鐗╅€氶亷鐢熺墿鑶滅殑骞剧ó杞�(zhu菐n)閬�(y霉n)姗�(j墨)鍒躲€佸奖闊胯棩鐗╂秷鍖栭亾鍚告敹鐨勭敓鐞嗗洜
绱犺垏钘ョ墿鍥犵礌鍜屽姂鍨嬪洜绱�銆佺敓鐗╄棩鍔戝(xu茅)鍒嗛绯荤当(t菕ng)鍙婃寚灏�(d菐o)鍙ｆ湇鍒跺姂
瑷�(sh猫)瑷�(j矛)鐨勫熀鏈柟娉�銆佽儍鑵搁亾鐨勭祼(ji茅)妲�(g貌u)鍙婂姛鑳藉拰钘ョ墿鐨勫惛鏀堕亷绋�銆佸彛鏈�
钘ョ墿鍚告敹鐨勭爺绌舵柟娉曡垏鎶€琛�(sh霉)銆�
3锛庨潪鍙ｆ湇钘ョ墿鍚告敹锛氭敞灏勭郸钘�銆佸惛鍏ョ郸钘�銆佺毊鑶氱郸钘�銆佺洿鑵哥郸钘�銆侀蓟鑵旂郸钘�銆佸彛鑵旂矘
3
鑶滅郸钘�銆佺溂閮ㄧ郸钘ョ殑鍚告敹閬庣▼銆佸惛鏀堕€斿緫鍙婂奖闊垮惛鏀剁殑鍥犵礌銆�
4锛庤棩鐗╁垎甯冿細钘ョ墿鍒嗗竷閬庣▼鍙婂叾褰遍熆鍥犵礌銆佽〃瑙€鍒嗗竷瀹圭⿳鐨勯噸瑕佹剰缇┿€�
5锛庤棩鐗╀唬璎濓細钘ョ墿浠ｈ瑵鐨勪富瑕侀€斿緫鍙婇儴浣嶈垏閬庣▼銆佽棩鐗╀唬璎濆皪钘ョ悊浣滅敤鐨勫奖闊�銆佷富瑕�
浠ｈ瑵閰�--娣峰悎鍔熻兘姘у寲閰剁殑鎬ц唱(zh矛)鍜屼唬璎濇浠�銆侀閬庢晥鎳�(y墨ng)瀹氱京鍙婂叾灏嶈棩鐗�
浣滅敤鐨勫奖闊�銆佽倽鎻愬彇鐜囩殑姒傚康鍙婂奖闊胯棩鐗╀唬璎濈殑鍥犵礌銆佺郸钘ラ€斿緫銆佺郸钘�
鍔戦噺鍜屽姂鍨嬪皪钘ョ墿浠ｈ瑵鐨勫奖闊�銆侀叾鎶戝埗鍜岄叾瑾樺皫(d菐o)浣滅敤灏嶈棩鐗╀唬璎濈殑褰遍熆銆�
6锛庤棩鐗╂帓娉勶細钘ョ墿鑵庢帓娉勭殑涓夌ó姗�(j墨)鍒躲€佽厧灏忕悆?y脿n)V閬庣殑鐗归粸(di菐n)銆佽厧灏忕涓诲嫊(d貌ng)鍒嗘硨鐨勭壒寰�銆�
褰遍熆鑵庢帓娉勭殑涓昏鍥犵礌銆佽厧娓呴櫎鐜囩殑鎰忕京鍙婂皪钘ョ墿浣滅敤鐨勫奖闊�銆佽棩鐗╄喗
姹佹帓娉勯亷绋嬪強鑶芥眮鎺掓硠鐨勭壒寰併€佽吀鑲濆惊鐠�(hu谩n)姒傚康鍙婂皪钘ョ墿浣滅敤鐨勫奖闊�銆�
7.钘ョ墿鍕�(d貌ng)鍔涘(xu茅)姒傝堪锛氳棩鐗╁嫊(d貌ng)鍔涘(xu茅)鐨勫畾缇╁拰鐮旂┒鍏�(n猫i)瀹�銆佽棩鐗╁嫊(d貌ng)鍔涘(xu茅)闅斿妯″瀷鐨勬蹇靛強钘ョ墿
杞�(zhu菐n)閬�(y霉n)閬庣▼涓殑閫熷害琛ㄩ仈(d谩)寮忓強鎰忕京銆侀€熺巼甯告暩(sh霉)銆佺敓鐗╁崐琛版湡銆佽〃瑙€鍒嗗竷瀹�
绌�銆佹竻闄ょ巼鐨勫畾缇╁拰鎰忕京銆�
8锛庡柈瀹ゆā鍨嬶細鎺屾彙鍠妯″瀷闈滆剤娉ㄥ皠銆侀潨鑴堟淮娉�銆佽绠″绲﹁棩鐨勮锛堝翱锛夎棩婵冨害缍�(j墨ng)鏅�(sh铆)
璁婂寲鐨勭壒寰�銆佺浉鎳�(y墨ng)鐨勫叕寮忓強钘ョ墿鍕�(d貌ng)鍔涘(xu茅)鍙冩暩(sh霉)鐨勫熀鏈蹇靛拰姹傜畻鏂规硶銆�
9锛庡瀹ゆā鍨嬶細浜屽妯″瀷闈滆剤娉ㄥ皠绲﹁棩鍚�锛岃钘ユ績搴︾稉(j墨ng)鏅�(sh铆)璁婂寲鍏紡銆佽棩鐗╁嫊(d貌ng)鍔涘(xu茅)鍙冩暩(sh霉)鐨�
鍚京鍙婂弮鏁�(sh霉)姹傜畻銆�
10锛庡鍔戦噺绲﹁棩锛氬鍔戦噺鍑芥暩(sh霉)銆佺┅(w臎n)鎱�(t脿i)琛€钘ユ績搴�銆佺┅(w臎n)鎱�(t脿i)骞冲潎琛€钘ユ績搴�銆侀仈(d谩)鍧垎?j菒n)?sh霉)銆佽搫绌嶅洜
瀛愩€佹尝鍕�(d貌ng)搴︾殑瀹氱京鑸囪▓(j矛)绠楁柟娉曪紱寰炲柈鍔戦噺绲﹁棩鐨勮钘ユ績搴�-鏅�(sh铆)闁撴柟绋嬪紡杞�(zhu菐n)
璁�?y艒u)姗硅矞?f霉)绲﹁棩鍚庢柟绋嬪紡鐨勬柟娉�銆�
11銆傞潪绶氭€ц棩鐗╁嫊(d貌ng)鍔涘(xu茅)锛氶潪绶氭€ц棩鐗╁嫊(d貌ng)鍔涘(xu茅)鐨勭壒榛�(di菐n)鍙婂彲鑳藉瓨鍦ㄩ潪绶氭€ц棩鐗╁嫊(d貌ng)鍔涘(xu茅)鐗瑰緛鐨�
楂斿収(n猫i)閬庣▼銆侀潪绶氭€ц棩鐗╁嫊(d貌ng)鍔涘(xu茅)璀�(sh铆)鍒ユ柟娉曞強闈炵窔鎬ц棩鐗╁嫊(d貌ng)鍔涘(xu茅)鏂圭▼銆�
12. 钘ョ墿鍕�(d貌ng)鍔涘(xu茅)鍦ㄨ嚚搴婅棩瀛�(xu茅)涓殑鎳�(y墨ng)鐢細鑷ㄥ簥绲﹁棩鏂规瑷�(sh猫)瑷�(j矛)鐨勪富瑕佹柟娉�銆佽厧鍔熻兘娓涢€€鎮ｈ€�
鐨勫姂閲忚(di脿o)绡€(ji茅)鏂规硶銆佹不鐧傝棩鐗╃洠(ji膩n)娓殑鑷ㄥ簥鎳�(y墨ng)鐢�銆佺兢楂旇棩鐗╁嫊(d貌ng)鍔涘(xu茅)鐨勬蹇�銆佺郸
钘ユ柟妗堝€�(g猫)楂斿寲鍜屾不鐧傝棩鐗╃洠(ji膩n)娓殑涓昏鍏�(n猫i)瀹�銆�
13銆傝棩鐗╁嫊(d貌ng)鍔涘(xu茅)鍦ㄦ柊钘ョ爺绌朵腑鐨勬噳(y墨ng)鐢細鏂拌棩钘ョ墿鍕�(d貌ng)鍔涘(xu茅)鐮旂┒鐨勫熀鏈収(n猫i)瀹瑰拰鍩烘湰鏂规硶銆佺敓
鐗╁埄鐢ㄥ害鍜岀敓鐗╃瓑鏁堟€х殑姒傚康鑸囪│椹�(y脿n)鏂规硶銆佺珐鎺ч噵鍒跺姂鐨勯珨鍏�(n猫i)澶栬⿻(p铆ng)鍍�(ji脿)鏂�
娉曞強鍔戦噺瑷�(sh猫)瑷�(j矛)鏂规硶銆�
浜�銆� 钘ョ墿鍒嗘瀽锛堝寘鎷垎鏋愬寲瀛�(xu茅)锛�
1. 瑾ゅ樊銆佹湁鏁堟暩(sh霉)瀛楃殑姒傚康鍙婂叾琛ㄩ仈(d谩)锛屽垎鏋愭暩(sh霉)鎿�(j霉)铏曠悊鐨勬柟娉�銆�
2. 瀹归噺鍒嗘瀽鐨勫熀鏈蹇靛拰鍩烘湰瑷�(j矛)绠楁柟娉曪紱閰稿牽婊村畾銆侀潪姘存淮瀹氥€佺怠(lu貌)鍚堟淮瀹�銆佹哀鍖栭倓
鍘熸淮瀹�銆佹矇娣€婊村畾娉曠瓑鐨勫熀鏈師鐞嗭紱瀹归噺鍒嗘瀽鍦ㄨ棩鐗╁垎鏋愪腑鐨勬噳(y墨ng)鐢�銆�
3. 鐔熺反鎺屾彙绱涓€鍙鍒嗗厜鍏夊害娉曠殑鍩烘湰鍘熺悊銆佸(sh铆)椹�(y脿n)鎿嶄綔鏂规硶鍙婂叾鎳�(y墨ng)鐢�锛屾帉鎻＄啋鍏�
鍒嗘瀽銆佺磪澶栧惛鏀跺厜璀滄硶銆佹牳纾佸叡鎸尝璀滄硶鍙婅唱(zh矛)璀滄硶鐨勫熀鏈師鐞嗗強鏂规硶鎳�(y墨ng)鐢ㄣ€�
4. 鑹茶瓬娉曞熀鏈師鐞嗚垏鐞嗚珫锛岃壊璀滄硶鏈夐棞(gu膩n)琛�(sh霉)瑾�銆佸畾鎬у拰瀹氶噺鍒嗘瀽鏂规硶锛岃憲閲嶆帉鎻¤杽灞�
鑹茶瓬銆佹埃鐩歌壊璀滄硶鍜岄珮鏁堟恫鐩歌壊璀滅殑鍒嗛洟鍘熺悊鍙婂叾鍦ㄩ珨鍏�(n猫i)澶栬棩鐗╁垎鏋愪腑鐨勬噳(y墨ng)鐢紱
钖勫堡鑹茶瓬鍒嗛洟鎿嶄綔閬庣▼锛屾埃鐩歌壊璀滃剙鍜岄珮鏁堟恫鐩歌壊璀滃剙绲�(ji茅)妲�(g貌u)鍜屽伐浣滄祦绋�锛岃壊璀滃垎
闆㈠強妾㈡脯姊濅欢鐨勯伕鎿�銆�
5. 钘ュ搧妾㈤(y脿n)鐨勫熀鏈▼搴�锛涚啛鎮夋垜鍦嬬従(xi脿n)琛岀殑钘ュ搧璩�(zh矛)閲忔(bi膩o)婧�(zh菙n)锛涘叏闈㈡帶鍒惰棩鍝佽唱(zh矛)閲忕殑绉戝(xu茅)
绠＄悊鐨勪富瑕佸収(n猫i)瀹�锛涗腑鍦嬭棩鍏哥従(xi脿n)琛岀増鐨勪富瑕佸収(n猫i)瀹硅垏鐗归粸(di菐n)锛涗簡瑙ｄ富瑕佺殑鍦嬪钘ュ吀銆�
6. 鎺屾彙甯哥敤閼掑垾瑭﹂(y脿n)鐨勫師鐞嗗拰瀵�(sh铆)椹�(y脿n)姊濅欢銆�
7. 钘ョ墿绱斿害鐨勬蹇佃垏瑕佹眰锛涢洔璩�(zh矛)鐨勪締婧愯垏绋锛涜棩鐗╀腑涓€鑸洔璩�(zh矛)鐨勬鏌ラ爡(xi脿ng)鐩垏鏂规硶锛�
闆滆唱(zh矛)闄愰噺妾㈡煡鐨勮〃绀哄拰瑷�(j矛)绠楁柟娉�锛涚壒娈婇洔璩�(zh矛)甯哥敤鐨勬鏌ユ柟娉曘€�
8. 瀹氶噺鍒嗘瀽妯ｅ搧鐨勫墠铏曠悊鏂规硶椤炲瀷銆佸師鐞嗗強鎿嶄綔瑕侀粸(di菐n)锛涢噸榛�(di菐n)鎺屾彙姘х摱鐕冪噿娉曡垏鍑辨皬
瀹氭爱娉曠殑鍘熺悊銆佸剙鍣ㄥ強鎿嶄綔瑕侀粸(di菐n)锛涙帉鎻″垎鏋愭柟娉曟晥鑳芥寚妯�(bi膩o)鐨勫畾缇�銆佹剰缇┿€佽▓(j矛)绠楁柟
4
娉�銆傛帉鎻￠珨鍏�(n猫i)鐢熺墿妯ｅ搧鍒嗘瀽鐨勫墠铏曠悊鎶€琛�(sh霉)銆�
9. 宸存瘮濡ラ钘ョ墿鐨勫寲瀛�(xu茅)绲�(ji茅)妲�(g貌u)鑸囧垎鏋愭柟娉曢枔鐨勯棞(gu膩n)绯�锛岀啛鎮変唬琛ㄦ€ц棩鐗╃殑鍖栧(xu茅)鎬ц唱(zh矛)鑸囧父
鐢ㄩ憭鍒ヨ│椹�(y脿n)鏂规硶鍙婂叾鍘熺悊锛屽父鐢ㄥ惈閲忔脯瀹氱殑鏂规硶鍙婂叾鍘熺悊銆�
10. 鑺抽吀鍙婂叾閰钘ョ墿鐨勭祼(ji茅)妲�(g貌u)銆佹€ц唱(zh矛)鑸囧垎椤�锛岀啛鎮変唬琛ㄦ€ц棩鐗╁強鍏堕憭鍒�銆佹鏌ュ強鍚噺
娓畾鏂规硶銆傝棩鐗╃殑绲�(ji茅)妲�(g貌u)銆佸悎鎴愯矾绶氳垏閼掑垾銆佹鏌ャ€佸惈閲忔脯瀹氭柟娉曚箣闁撶殑闂�(gu膩n)鑱�(li谩n)銆�
11. 鑺抽叞鑳洪鍜屽皪姘ㄥ熀鑻敳閰搁叝椤炶棩鐗╃殑绲�(ji茅)妲�(g貌u)銆佹€ц唱(zh矛)鑸囧垎椤烇紱鐔熸倝浠ｈ〃鎬ц棩鐗╁強鍏堕憭
鍒�銆佹鏌ユ柟娉�锛涜嫰涔欒兒椤炶棩鐗╃殑閼掑垾鑸囬洔璩�(zh矛)妾㈡煡銆傝姵閰拌兒椤�銆佸皪姘ㄥ熀鑻敳閰搁叝椤�
鍜岃嫰涔欒兒椤炶棩鐗╃殑鍚噺娓畾鏂规硶銆�
12. 闆滅挵(hu谩n)椤炶棩鐗╃殑绲�(ji茅)妲�(g貌u)鐗瑰緛鑸囧垎椤烇紱鐔熸倝浠ｈ〃鎬ц棩鐗╃殑閼掑垾銆佹鏌�銆佸惈閲忔脯瀹氭柟娉曪紱
閲嶉粸(di菐n)鎺屾彙闈炴按鍫块噺娉�銆佹哀鍖栭倓鍘熸淮瀹氭硶銆佹瘮鑹叉硶銆佽悆鍙�-闆欐尝闀峰垎鍏夊厜搴︽硶銆侀珮鏁�
娑茬浉鑹茶瓬娉曠瓑娓畾闆滅挵(hu谩n)椤炶棩鐗╃殑鏂规硶鍘熺悊鑸囪榛�(di菐n)銆�
13. 缍敓绱� A銆佺董鐢熺礌 E銆佺董鐢熺礌 B1銆佺董鐢熺礌 C 鐨勫父鐢ㄩ憭鍒�銆侀洔璩�(zh矛)妾㈡煡鑸囧惈閲忔脯瀹氭柟
娉曘€�
14. 鐢鹃珨婵€绱犻钘ョ墿鐨勭祼(ji茅)妲�(g貌u)鐗瑰緛銆佸垎椤�銆佺壒寰佸畼鑳藉湗(tu谩n)锛涙湰椤炶棩鐗╁父鐢ㄧ殑閼掑垾鏂规硶锛涢珮
鏁堟恫鐩歌壊璀滆壊璀滄硶銆佹瘮鑹叉硶鐨勬柟娉曞師鐞嗗強閬╃敤鑼冨湇銆�
15. 鎶楃敓绱犻钘ョ墿鐨勫垎椤炶垏绲�(ji茅)妲�(g貌u)鐗瑰緛锛涚啛鎮� 尾-鍏�(n猫i)閰拌兒椤�銆佹皑鍩虹硸鐢欓銆佸洓鐠�(hu谩n)椤炴姉鐢熺礌
鐨勭悊鍖栨€ц唱(zh矛)鑸囬憭鍒ヨ│椹�(y脿n)锛涙帉鎻″井鐢熺墿妾㈠畾娉曠殑鍩烘湰鏂规硶鍙婂叾鍎�(y艒u)缂洪粸(di菐n)锛汬PLC 娉曟脯
瀹氭叾澶ч湁绱犲惈閲忕殑鍘熺悊鍜屾柟娉曡榛�(di菐n)锛屾姉鐢熺礌钘ョ墿涓珮鍒嗗瓙闆滆唱(zh矛)鐨勪締婧愩€佺壒榛�(di菐n)鍙婃帶
鍒舵柟娉曘€�
16. 钘ョ墿鍒跺姂鍒嗘瀽鐨勭壒榛�(di菐n)锛涚墖鍔戝拰娉ㄥ皠鍔戝垎鏋愮殑甯歌(gu墨)妾㈡煡闋�(xi脿ng)鐩垏娓畾鏂规硶锛涘父鐢ㄩ檮鍔�
鍔戝皪鏈夋晥鎴愬垎鍚噺娓畾鐨勫共鎿惧強鍏舵帓闄ゆ柟娉�锛涘京(f霉)鏂瑰埗鍔戠殑鐗归粸(di菐n)鍜屽垎鏋愭柟娉�锛涘埗鍔�
鍚噺娓畾绲�(ji茅)鏋滅殑琛ㄧず鏂规硶鑸囪▓(j矛)绠楁柟娉�銆�
17. 鐢熺墿鍒跺搧鐨勫畾缇�銆佺壒榛�(di菐n)鍙婂垎椤烇紱鎺屾彙鐢熺墿鍒跺搧甯哥敤鐨勯憭鍒�銆佹鏌ラ爡(xi脿ng)鐩垏鍚噺锛堟晥
鍍�(ji脿)锛夋脯瀹氭柟娉曪紱鐔熸倝鐢熷寲鍒嗘瀽娉曡垏鐢熺墿妾㈠畾娉曟脯瀹氱敓鐗╁埗鍝佺殑鍩烘湰鏂规硶鑸囨噳(y墨ng)鐢�銆�
18. 涓棩鍒跺姂鍒嗘瀽鐨勭壒榛�(di菐n)鍙婂熀鏈▼搴�锛涗腑钘ュ埗鍔戝父鐢ㄧ殑妯ｅ搧鍒跺倷鏂规硶鍜屽垎闆㈡彁绱旀柟娉�锛�
鍚勯涓棩鍒跺姂鐨勫熀鏈唱(zh矛)閲忔帶鍒堕爡(xi脿ng)鐩垏瑕佹眰锛涗腑钘ュ埗鍔戝父鐢ㄧ殑鐞嗗寲閼掑垾鏂规硶銆侀洔璩�(zh矛)
妾㈡煡闋�(xi脿ng)鐩強鍚噺娓畾鏂规硶锛涗腑钘ユ寚绱嬪湒璀滄妧琛�(sh霉)銆�
19. 钘ュ搧璩�(zh矛)閲忔(bi膩o)婧�(zh菙n)鐨勫垎椤烇紝鍒惰▊鐨勭洰鐨�銆佹剰缇╁強鍘熷墖锛涜棩鍝佽唱(zh矛)閲忔(bi膩o)婧�(zh菙n)鐨勪富瑕佸収(n猫i)瀹瑰強瑕�
榛�(di菐n)銆�
20. 钘ョ墿鐝�(xi脿n)浠ｈ壊璀滄硶銆佸厜璀滄硶鍙婅伅(li谩n)鐢ㄦ妧琛�(sh霉)鐨勯€�(j矛n)灞曘€�
IV. 椤屽瀷绀轰緥鍙婂弮鑰冪瓟妗�
鐢熺墿钘ュ姂瀛�(xu茅)鑸囪棩鐗╁嫊(d貌ng)鍔涘(xu茅)锛�
涓€锛庡悕瑭炶В閲嬮锛堟湰椤屽寘鎷� 1鈥�6 椤屽叡 6 鍊�(g猫)灏忛锛屾瘡灏忛 3 鍒�锛屽叡 18 鍒嗭級銆�
1锛嶢bsolute bioavailability 锛氱禃灏嶇敓鐗╁埄鐢ㄥ害锛氳棩鐗╅€�(j矛n)鍏ラ珨寰挵(hu谩n)鐨勯噺鑸囩郸钘ュ姂閲忕殑姣斿€�锛�
瀵�(sh铆)闅涘伐浣滀腑鐢ㄨ绠″绲﹁棩鑸囬潨鑴堟敞灏勭殑钘�-鏅�(sh铆)鏇茬窔涓嬮潰绌嶄箣姣旇▓(j矛)绠楄绠″绲﹁棩鍒跺姂鐨勭禃
灏嶇敓鐗╁埄鐢ㄥ害銆�
2锛庤钘ユ績搴﹁畩鍖栫巼锛氱┅(w臎n)鎱�(t脿i)鏈€澶ц钘ユ績搴﹁垏绌�(w臎n)鎱�(t脿i)鏈€灏忚钘ユ績搴﹀樊锛岃垏绌�(w臎n)鎱�(t脿i)鏈€灏忚钘ユ績搴�
鐨勭櫨鍒�?j菒n)?sh霉)銆�
3锛庡钩鍧囩┅(w臎n)鎱�(t脿i)琛€钘ユ績搴︼細鐣�(d膩ng)琛€钘ユ績搴﹂仈(d谩)鍒扮┅(w臎n)瀹氬悗锛屽湪涓€鍊�(g猫)鍔戦噺闁撻殧鏅�(sh铆)闁撳収(n猫i)锛岃钘ユ績搴�-
鏅�(sh铆)闁撴洸绶氫笅闈㈢⿳闄や互闁撻殧鏅�(sh铆)闁撶殑鍟�銆�
4锛巈nterohepatic cycle锛氳吀鑲濆惊鐠�(hu谩n)锛氬湪鑶芥眮涓帓鍗�(xi茅)鐨勮棩鐗╂垨鍏朵唬璎濈墿鍦ㄥ皬鑵镐腑绉诲嫊(d貌ng)鏈�
闁撻噸鏂拌閲嶅惛鏀惰繑鍥炶倽闁€闈滆剤锛屽苟缍�(j墨ng)鑲濊嚐閲嶆柊閫�(j矛n)鍏ュ叏韬惊鐠�(hu谩n)锛岀劧鍚庡啀鍒嗘硨锛岀洿鑷虫渶绲傚緸
楂斿収(n猫i)鎺掑嚭鐨勭従(xi脿n)璞�銆�
5
5锛嶳enal clearance锛氳厧娓呴櫎鐜囷細鍠綅鏅�(sh铆)闁撳収(n猫i)鑵庤兘灏囧灏戝绌嶇殑琛€婕夸腑瑭茶棩鐗╂竻闄ょ殑鑳�
鍔�銆�
6锛巐oading dose锛氬湪闈滄淮鏅�(sh铆)浣胯钘ユ績搴﹁繀閫熼仈(d谩)鍒扮┅(w臎n)鎱�(t脿i)锛岄潨娉ㄧ殑涓€鍊�(g猫)鍔戦噺銆傦紙鎴栦娇琛€钘ユ績
搴﹁繀閫熼仈(d谩)鍒扮┅(w臎n)鎱�(t脿i)绲︾殑涓€鍊�(g猫)鍔戦噺锛�
浜岋紟濉┖椤岋紙鏈鍖呮嫭 1-6 椤屽叡 22 绌�锛屾瘡绌� 1 鍒嗭紝鍏� 22 鍒嗭級銆�
1.娑堥櫎鏄紙浠ｈ瑵锛夎垏锛堟帓娉勶級閬庣▼鐨勭稖鍚堟晥鏋溿€傝棩鐗╁湪楂斿収(n猫i)鐨勶紙鍒嗗竷锛夎垏锛堟秷闄わ級
閬庣▼涓€鑸附绋辩偤铏曠疆銆�
2.钘ョ墿楂斿収(n猫i)浠ｈ瑵鍒嗙偤鍏╃浉锛岀涓€鐩哥殑鍙嶆噳(y墨ng)椤炲瀷鍖呮嫭锛堟哀鍖栵級銆侊紙閭勫師锛夊拰锛堟按瑙ｏ級銆�
3.鐢熺墿鍒╃敤搴︽槸鎸囪棩鐗╄鍚告敹閫�(j矛n)鍏ヨ娑插惊鐠�(hu谩n)鐨勶紙閫熷害锛夊拰锛堢▼搴︼級銆傚畠鏄 閲忓埗鍔戯紙璩�(zh矛)
閲忥級鐨勯噸瑕佹寚妯�(bi膩o)銆�
4.鑵庢帓娉勭殑姗�(j墨)鐞嗗寘鎷紙鑵庡皬鐞�?y脿n)V閬庯級 銆侊紙鑵庡皬绠″垎娉岋級 銆侊紙鑵庡皬绠￠噸鍚告敹锛�銆�
5.褰遍熆绲勭箶鍒嗗竷鐨勫洜绱犳湁锛堣娑插惊鐠�(hu谩n)锛夈€侊紙琛€婕胯泲鐧界祼(ji茅)鍚堬級 銆侊紙钘ョ墿鐞嗗寲鎬ц唱(zh矛)锛�銆�
锛堣棩鐗╄垏绲勭箶铔嬬櫧瑕拰鍔涳級銆侊紙钘ョ墿鐩镐簰浣滅敤锛夈€�
6.钘ョ墿鍚告敹鍙楅毃 pH 璁婂寲鑰岀敘(ch菐n)鐢熺殑锛堝垎瀛愬瀷锛夊拰锛堥洟瀛愬瀷锛夌殑姣斾緥鍙婃补姘村垎閰嶇郴鏁�(sh霉)鎵€鏀�
閰嶇殑鍋囪锛岀ū鐐� pH 鍒嗛厤鍋囪銆�
涓夛紟鍠爡(xi脿ng)閬告搰椤岋紙鏈鍖呮嫭 1-8 椤屽叡 8 鍊�(g猫)灏忛锛屾瘡灏忛 1 鍒�锛屽叡 8 鍒嗐€傚湪姣忓皬椤岀郸鍑虹殑浜�
鍊�(g猫)閬搁爡(xi脿ng)涓�锛屽彧鏈変竴鍊�(g猫)绗﹀悎椤岀洰瑕佹眰锛屾妸鎵€閬搁爡(xi脿ng)鍓嶇殑瀛楁瘝濉湪绛旈鍗＄浉鎳�(y墨ng)鐨勫簭铏�(h脿o)鍏�(n猫i)锛�銆�
閬告搰椤岀瓟椤屽崱锛�
椤岃櫉(h脿o) 1 2 3 4 5 6 7 8
绛旀 C D E E D C D E
1锛庝笉鏄棩鐗╅€氶亷鐢熺墿鑶滆綁(zhu菐n)閬�(y霉n)姗�(j墨)鐞嗙殑鏄�
A锛庝富鍕�(d貌ng)杞�(zhu菐n)閬�(y霉n)
B锛庝績閫�(j矛n)鎿�(ku貌)鏁�
C锛庢徊閫忎綔鐢�
D锛庤優椋蹭綔鐢�
E锛庤鍕�(d貌ng)鎿�(ku貌)鏁�
2锛庝互涓嬪摢姊濅笉鏄富鍕�(d貌ng)杞�(zhu菐n)閬�(y霉n)鐨勭壒寰�
A锛庢秷鑰楄兘閲�
B锛庡彲鑸囩祼(ji茅)妲�(g貌u)椤炰技鐨勭墿璩�(zh矛)鐧�(f膩)鐢熺鐖従(xi脿n)璞�
C锛庣敱浣庢績搴﹀悜楂樻績搴﹁綁(zhu菐n)閬�(y霉n)
D锛庝笉闇€杓夐珨閫�(j矛n)琛岃綁(zhu菐n)閬�(y霉n)
E锛庢湁椋藉拰鐙€鎱�(t脿i)
3锛庤棩鐗╁姂鍨嬪皪钘ョ墿鑳冭吀閬撳惛鏀跺奖闊垮洜绱犱笉鍖呮嫭
A锛庤棩鐗╁湪鑳冭吀閬撲腑鐨勭┅(w臎n)瀹氭€�
B锛庣矑瀛愬ぇ灏�
C锛庡鏅跺瀷
D锛庤В闆㈠父鏁�(sh霉)
E锛庤儍鎺掔┖閫熺巼
4锛庢煇钘ョ墿鐨� t1/2 鐐� 1 灏忔檪(sh铆)锛屾湁 40%鐨勫師褰㈣棩缍�(j墨ng)鑵庢帓娉勮€屾秷闄わ紝鍏朵綑鐨勫彈鍒扮敓鐗╄綁(zhu菐n)鍖�锛屽叾鐢�
鐗╄綁(zhu菐n)鍖栭€熺巼甯告暩(sh霉) Kb 绱勭偤
A锛�0.05 灏忔檪(sh铆)
-1
B锛�0.78 灏忔檪(sh铆)
-1
C锛�0.14 灏忔檪(sh铆)
-1
D锛�0.99 灏忔檪(sh铆)
-1
6
E锛�0.42 灏忔檪(sh铆)
-1
5锛庤婕胯泲鐧界祼(ji茅)鍚堢巼楂樼殑钘ョ墿锛屼竴鑸�
A锛庢父闆㈣棩鐗╂績搴﹂珮锛屼綔鐢ㄥ挤(qi谩ng)
B锛庢父闆㈣棩鐗╂績搴︿綆锛屼綔鐢ㄥ挤(qi谩ng)
C锛庢父闆㈣棩鐗╂績搴﹂珮锛屼綔鐢ㄥ急锛屾帓娉勬參
D锛庢父闆㈣棩鐗╂績搴︿綆锛屼綔鐢ㄥ急锛屾帓娉勬參
E锛庢父闆㈣棩鐗╂績搴︿綆锛屼綔鐢ㄥ急锛屾帓娉勫揩
6锛庣閰哥敇娌瑰彛鏈嶅悗琛€涓棩鐗╂績搴﹂仈(d谩)涓嶅埌娌荤檪婵冨害锛屽繀闇€鑸屼笅绲﹁棩锛岄€欐槸鍥�?y脿n)?br/>A锛庢钘ュ彛鏈嶄笉鍚告敹
B锛庢钘ュ彛鏈嶅惛鏀跺叆琛€閲忓皯
C锛庨閬庢秷闄ら噺澶�
D锛庢钘ユ帓娉勫揩
E锛庢钘ュ垎甯冮€熺巼楂�
7锛庢湁闂�(gu膩n)钘ョ墿寰炶厧鑷熸帓娉勭殑姝ｇ⒑鏁樿堪鏄�
A锛庤垏琛€婕胯泲鐧界祼(ji茅)鍚堢殑钘ョ墿鏄撳緸鑵庡皬鐞�?y脿n)V閬�
B锛庤В闆㈢殑钘ョ墿鏄撳緸鑵庡皬绠￠噸鍚告敹
C锛庤棩鐗╃殑鎺掓硠鑸囧翱娑� pH 鐒￠棞(gu膩n)
D锛庢敼璁婂翱娑� pH 鍙敼璁婅棩鐗╃殑鎺掓硠閫熷害
E锛庤棩鐗╃殑琛€婕挎績搴﹁垏灏挎恫涓殑婵冨害鐩哥瓑
8. 宸茬煡鏌愯棩鐨� t1/2 鐐� 3 灏忔檪(sh铆), vd 鐐� 130 鍗�, 鎿�(j霉)浠ヤ笂璩囨枡鎵€鑳藉仛鍑虹殑姝ｇ⒑鍒ゆ柗鏄�
A锛庢钘ュ緸鑵庡皬绠′富鍕�(d貌ng)鍒嗘硨鎺掓硠
B锛庢钘ヤ富瑕佸湪鑲濊嚐琚棩鐗╀唬璎濋叾浠ｈ瑵
C锛庢钘ョ偤涓€绱�(j铆)鍕�(d貌ng)鍔涘(xu茅)娑堥櫎
D锛庢钘ョ殑娑堥櫎閫熺巼甯告暩(sh霉)绱勭偤 50
E锛庢钘ョ殑琛€婕挎竻闄ょ巼绱勭偤 30 L/h
鍥涳紟澶氶爡(xi脿ng)閬告搰椤岋紙鏈鍖呮嫭 1-6 椤屽叡 6 鍊�(g猫)灏忛锛屾瘡灏忛 1.5 鍒�锛屽叡 9 鍒�銆傚湪姣忓皬椤岀郸鍑虹殑
浜斿€�(g猫)閬搁爡(xi脿ng)涓紝鏈夊鍊�(g猫)绗﹀悎椤岀洰瑕佹眰锛屾妸鎵€閬搁爡(xi脿ng)鍓嶇殑瀛楁瘝濉湪绛旈鍗＄浉鎳�(y墨ng)鐨勫簭铏�(h脿o)鍏�(n猫i)锛夈€�
閬告搰椤岀瓟椤屽崱锛�
椤岃櫉(h脿o) 1 2 3 4 5 6
绛旀 ABDE AE ABC AC DE ABCDE
1锛庨棞(gu膩n)浜庤棩鐗╁嫊(d貌ng)鍔涘(xu茅)涓敤鈥滈€熷害娉曗€濆緸灏胯棩鏁�(sh霉)鎿�(j霉)姹傜畻钘ョ墿鍕�(d貌ng)鍔涘(xu茅)鐨勬湁闂�(gu膩n)鍙冩暩(sh霉)鐨勬纰烘弿杩版槸
A锛庤嚦灏戞湁涓€閮ㄥ垎钘ョ墿寰炶厧鎺掓硠鑰屾秷闄�
B锛庨爤閲囩敤涓枔鏅�(sh铆)闁� t 涓締瑷�(j矛)绠�
C锛庡繀闋堟敹闆嗗叏閮ㄥ翱閲忥紙7 鍊�(g猫)鍗婅“鏈�锛屼笉寰楁湁鎼嶅け锛�
D锛庤宸洜绱犳瘮杓冩晱鎰燂紝瑭﹂(y脿n)鏁�(sh霉)鎿�(j霉)娉㈠嫊(d貌ng)澶�
E锛庢墍闇€鏅�(sh铆)闁撴瘮鈥滆櫑閲忔硶鈥濈煭
2锛庡奖闊块仈(d谩)宄版檪(sh铆)闁� tm 鐨勮棩鐗╁嫊(d貌ng)鍔涘(xu茅)鍙冩暩(sh霉)鏈�
A锛嶬 B锛巘m C锛嶺0 D锛嶧 E锛嶬a
3锛庡奖闊胯儍鎺掔┖閫熷害鐨勫洜绱犳槸
A锛庣┖鑵硅垏椋借吂 B锛庤棩鐗╁洜绱� C锛庨鐗╃殑绲勬垚鍜屾€ц唱(zh矛) D锛庤棩鐗╃殑澶氭櫠鍨�
E锛庤棩鐗╃殑娌规按鍒嗛厤绯绘暩(sh霉)
4锛庤棩鐗╂寜涓€绱�(j铆)鍕�(d貌ng)鍔涘(xu茅)娑堥櫎鍏锋湁浠ヤ笅鍝簺鐗归粸(di菐n)
A锛庤婕垮崐琛版湡鎭掑畾涓嶈畩
B锛庤棩鐗╂秷闄ら€熷害鎭掑畾涓嶈畩
7
C锛庢秷闄ら€熷害甯告暩(sh霉)鎭掑畾涓嶈畩
D锛庝笉鍙楄倽鍔熻兘鏀硅畩鐨勫奖闊�
E锛庝笉鍙楄厧鍔熻兘鏀硅畩鐨勫奖闊�
5锛庤棩鐗╄垏琛€婕胯泲鐧界祼(ji茅)鍚�
A锛庢湁鍒╀簬钘ョ墿閫�(j矛n)涓€姝ュ惛鏀�
B锛庢湁鍒╀簬钘ョ墿寰炶厧鑷熸帓娉�
C锛庡姞蹇棩鐗╃櫦(f膩)鎻綔鐢�
D锛庤婕胯泲鐧介噺浣庤€呮槗鐧�(f膩)鐢熻棩鐗╀腑姣�
E锛庡叐绋泲鐧界祼(ji茅)鍚堢巼楂樼殑钘ョ墿鏄撶櫦(f膩)鐢熺鐖疆鎻涚従(xi脿n)璞�
6锛庡湪 TDM 灏嶅€�(g猫)楂斿寲鐢ㄨ棩鏂规閫�(j矛n)琛岃(di脿o)鏁存檪(sh铆)锛岄渶鑰冩叜
A锛庢秷闄ら€熷害甯告暩(sh霉)
B锛庤钘ユ績搴�
C锛庢渶灏忔湁鏁堟績搴�
D锛庢渶灏忎腑姣掓績搴�
E锛庤倽鑵庡姛鑳�
浜旓紟瑷�(j矛)绠楅锛堟湰椤屽寘鎷� 1-3 椤屽叡 3 椤�锛�1 椤� 10 鍒嗭紝2銆�3 椤� 12 鍒�锛屽叡 34 鍒嗭級銆�
1锛庤瑎钘ョ墿鍦ㄩ珨鍏�(n猫i)鎸変竴绱�(j铆)鍕�(d貌ng)鍔涘(xu茅)娑堥櫎锛岄潨鑴堟敞灏勫悗 1 灏忔檪(sh铆)銆�3 灏忔檪(sh铆)鐨勮钘ユ績搴﹀垎鍒ョ偤 8渭
g/ml 鍙� 4渭 g/ml銆傛眰锛�1锛塼1/2锛涳紙2锛夌稉(j墨ng)閬� 6 鍊�(g猫)鍗婅“鏈燂紝楂斿収(n猫i)娈樹綑钘ラ噺鍦� c-t 鏇茬窔涓嬬殑闈�
绌�銆傦紙10 鍒嗭級
瑙ｏ細锛�1锛塼1/2=2 灏忔檪(sh铆)
锛�2锛変緷椤屾剰锛�6 鍊�(g猫)鍗婅“鏈熺稉(j墨ng)姝锋檪(sh铆)闁撶偤 6脳2=12 灏忔檪(sh铆)
鍥�?y脿n)?br/>lgC12=lgC0-Kt12/2.303鈥︹€︹€�.(1)
lgC1=lgC0-Kt1/2.303鈥︹€︹€︹€�(2)
(1)-(2)寰� lgC12-lgC1=Kt12/2.303(t1-t12)
lgC12= lgC1+Kt12/2.303(t1-t12)
lgC12= lg8+0.693/2/2.303(1-12)
=-0.7519
C12=0.1771(渭 g/ml)
鎵€浠� AUC
12~鈭�
=C12/K=0.1771/0.3465=0.51(渭 g/ml?h)
绛旓細.......
2锛庢煇鍙ｆ湇钘ョ墿绲﹁棩閲忕偤 500mg锛孎(xi脿n)=0.60锛孠a=0.1093min
-1
锛岃ō(sh猫)瑭茶棩鐗╁湪楂斿収(n猫i)鐐轰竴绱�(j铆)娑堥櫎锛�
K=0.0171min
-1
锛岀稉(j墨ng)娓畾 Vd=626 L锛屾眰瑭茶棩鐨� tp 鍜� Cp銆傦紙12 鍒嗭級
瑙ｏ細锛�1锛塼p=2.303(lgKa-lgK)/(Ka-K)=20(min)
锛�2锛塁p=FX0e
-Kt
p/V=0.0034(mg/L)
绛旓細......
3锛庢煇鎶楃敓绱犳渶澶у畨鍏ㄦ不鐧傛績搴︼紙MTC锛夌偤 35渭 g/ml锛屾渶灏忔湁鏁堟績搴︼紙MEC锛夌偤 10渭
g/ml锛岀敓鐗╁崐琛版湡鐐� 3 灏忔檪(sh铆)锛屽凡鐭� 7.5mg/kg 鍙敘(ch菐n)鐢� C0=25渭 g/ml銆傚晱浠ユ€庢ǎ鐨勭郸钘ラ枔
闅�锛屽澶х殑鍔戦噺鍋氶噸寰�(f霉)娉ㄥ皠锛屼娇琛€钘ユ績搴﹀湪 10~35渭 g/ml 涔嬮枔銆傦紙12 鍒嗭級
瑙ｏ細 鍥�?y脿n)?Cmin
ss
/Cmax
ss
=e
-kT
T=5.44h 鍙堝洜?y脿n)?Cmax
ss
=C0 1/(1- e
-kT
) C0=25渭 g/ml
鏁呴噸寰�(f霉)娉ㄥ皠鐨勫姂閲忔噳(y墨ng)鐐� 7.5渭 g/kg銆�
绛旓細鈥︹€�
鍏紟鍟忕瓟椤岋紙鏈鍖呮嫭 1-8 椤屽叡 8 椤岋紝1-7 姣忛 7 鍒�锛�8 椤� 12 鍒�锛屽叡 61 鍒嗭級
1锛庤棩鐗╄婕胯泲鐧界祼(ji茅)鍚堢巼杓曞井璁婂寲锛岃棩鐞嗕綔鐢ㄥ挤(qi谩ng)搴︽槸鍚﹂’钁楄畩鍖�锛熺偤浠€涔�锛�
8
绛旓細鏄紙3 鍒嗭級锛岀祼(ji茅)鍚堢巼寰� 99%璁�?y艒u)?98%锛岀敘(ch菐n)鐢熻棩鐞嗕綔鐢ㄧ殑钘ラ噺澧炲姞 1 鍊嶏紙4 鍒嗭級
2锛庤ō(sh猫)瑷�(j矛)绶╂帶閲嬪埗鍔戠郸钘ユ槸鍚﹂渶瑕佽矤(f霉)鑽峰姂閲忥紵鐐轰粈涔�锛�
绛旓細闇€瑕侊紙3 鍒嗭級锛岃繀閫熼仈(d谩)鍒版湁鏁堣钘ユ績搴︼紙4 鍒嗭級
3锛庡浣曞垽鍒ヨ棩鐗╁湪楂斿収(n猫i)瀛樺湪闈炵窔鎬у嫊(d貌ng)鍔涘(xu茅)鐗瑰緛
绛旓細闈滆剤娉ㄥ皠楂樹腑浣庝笁鍊�(g猫)鍔戦噺绲�锛岋紙1 鍒嗭級浣滆棩-鏅�(sh铆)鏇茬窔锛岃嫢涓夋绶氬钩琛岀偤绶氭€�锛屽弽涔�
鐐洪潪绶氭€э紱锛�2 鍒嗭級浠ヨ钘ユ績搴﹀€奸櫎浠ョ浉鎳�(y墨ng)鐨勫姂閲忓皪鏅�(sh铆)闁� t 浣滃湒锛岀湅鏇茬窔鏄惁閲嶇枈锛�
锛�1.5 鍒嗭級浠� AUC 闄や互鐩告噳(y墨ng)鐨勫姂閲�锛涳紙1.5 鍒嗭級灏囨瘡鍊�(g猫)婵冨害-鏅�(sh铆)闁撴暩(sh霉)鎿�(j霉)鎸夌窔鎬ц檿鐞�锛岃▓(j矛)
绠楀嫊(d貌ng)鍔涘(xu茅)鍙冩暩(sh霉)銆傦紙1 鍒嗭級
4锛庣敱浜庣柧鐥呭皫(d菐o)鑷存偅鑰呬綆铔嬬櫧琛€鐧ユ檪(sh铆)锛屽急閰告€ц棩鐗╅倓鏄急鍫挎€ц棩鐗╃殑铔嬬櫧绲�(ji茅)鍚堢巼鏇村鏄撶櫦(f膩)
鐢熻畩鍖�锛熺偤浠€涔堬紵
绛旓細鍫挎€ф敼璁婏紙3 鍒嗭級锛岄吀鎬ц泲鐧姐€佽剛铔嬬櫧鏄撶櫦(f膩)鐢熻畩鍖栵紙4 鍒嗭級
5锛� 閲嶅京(f霉)绲﹁棩琛€钘ユ績搴﹂棞(gu膩n)绯诲紡鐨勫墠鎻愭浠舵槸浠€涔�锛�
绛旓細姣忔绲﹁棩鍔戦噺鐩稿悓锛岋紙3.5 鍒嗭級绲﹁棩闁撻殧鏅�(sh铆)闁撶浉鍚岋紙3.5 鍒嗭級
6锛� 浣曡瑐娈樻暩(sh霉)娉�锛熸€庢ǎ姹� Ka锛�
绛旓細灏囦竴姊濇洸绶氬垎瑙ｆ垚鑻ュ共鎸囨暩(sh霉)鎴愬垎鐨勪竴绋柟娉曪紙2 鍒嗭級锛涙眰 Ka (5 鍒�)锛�1锛変綔鍦� 锛�2锛�
鐢ㄦ秷闄ょ浉姹� K (3) 姹傚惛鏀剁浉澶栨帹婵冨害鍙婃畼鏁�(sh霉)婵冨害锛�4锛夊緸鍙冩暩(sh霉)绶氭眰鏂滅巼 Ka
7锛庡垽鍒ラ殧瀹ゆā鍨嬬殑鏂规硶鏈夊摢浜�锛�
绛旓細鍦栧舰娉曪紙2 鍒嗭級 銆佹摤鍚堝害娉曪紙2 鍒嗭級銆丄IC 娉曪紙2 鍒嗭級銆丗 妾㈤(y脿n)鎴栨畼宸钩鏂瑰拰锛�1 鍒嗭級
8. 瑭﹁堪鏂板姂鍨嬬殑闁嬬櫦(f膩)鑸囩敓鐗╄棩鍔戝(xu茅)銆佽棩鐗╁嫊(d貌ng)鍔涘(xu茅)鐨勯棞(gu膩n)绯�銆�
绛旓細锛堢暐锛�
娉細鍟忕瓟椤岀郸鍑虹殑鍙槸绛旀瑕侀粸(di菐n)
钘ョ墿鍒嗘瀽锛堝寘鎷垎鏋愬寲瀛�(xu茅)閮ㄥ垎锛夛細
涓€锛庡悕瑭炶В閲嬶細锛堟湰椤屽寘鎷� 1-8 椤屽叡 8 鍊�(g猫)灏忛锛屾瘡灏忛 3 鍒�锛屽叡 24 鍒�锛岀炕璀垚涓枃鍚庡啀瑙�
閲嬩箣锛�
1锛嶥ifferential Scanning Calorimetry锛氬樊绀烘巸鎻忛噺鐔辨硶锛屾脯閲忕董鎸佹ǎ鍝佽垏鍙冩瘮鐗╄唱(zh矛)鐨勬韩
搴︾浉鍚�锛岀郴绲�(t菕ng)鎵€闇€杓哥郸寰呮脯鐗╄唱(zh矛)鍜屽弮姣旂墿鐨勮兘閲忓樊鑸囨韩搴�(鎴栨檪(sh铆)闁�)鐨勭啽鍒嗘瀽鎶€琛�(sh霉)銆�
鍑芥暩(sh霉)闂�(gu膩n)绯荤偤锛氱啽娴佺巼--婧害(T)鎴栨檪(sh铆)闁�(t)
2锛嶴ensitivity锛氬弽鎳�(y墨ng)鐨勯潏鏁忓害锛屽湪涓€瀹氭浠朵笅锛岃兘鍦ㄧ洝鍙兘绋€鐨勬憾娑蹭腑瑙€娓嚭鐩″彲鑳藉皯
閲忕殑渚涜│鍝�锛屽弽鎳�(y墨ng)灏嶉€欎竴瑕佹眰鎵€鑳芥豢瓒崇殑绋嬪害銆�
3锛嶴pecificity锛氬皥灞€�锛屾寚鏈夊叾浠栨垚鍒嗭紙闆滆唱(zh矛)銆侀檷瑙ｇ墿銆佽紨鏂欑瓑锛夊彲鑳藉瓨鍦ㄦ儏娉佷笅锛岄噰
鐢ㄧ殑鏂规硶鑳芥簴(zh菙n)纰烘脯瀹氬嚭琚脯鐗╃殑鐗规€�銆�
4锛� Linearity锛氱窔鎬�锛屽湪瑷�(sh猫)瑷�(j矛)鐨勮寖鍦嶅収(n猫i)锛屾脯瑭︾祼(ji茅)鏋滆垏瑭︽ǎ涓娓墿婵冨害鐩存帴鍛堟姣旈棞(gu膩n)绯�
鐨勭▼搴︺€�
5锛嶴olid Phase Extraction锛氬浐鐩歌悆鍙�锛屽皣妯ｅ搧婧舵恫閫氶亷闋�(y霉)鍏堝～鍏呭浐瀹氱浉濉枡鐨勬煴瀛�锛屽緟
娓祫鍒嗛€氶亷鍚搁檮銆佸垎閰嶇瓑褰㈠紡琚埅鐣欙紝鐒跺悗鐢ㄩ仼鐣�(d膩ng)?sh霉)濞滆粐鈹柕?锛岄仈(d谩)鍒板垎闆�銆佸噲鍖栧拰瀵�
闆嗙殑鐩殑銆�
6锛嶴elected Ion Monitoring锛氶伕鎿囬洟瀛愭娓紝鍦ㄨ唱(zh矛)璀滃湒涓浐瀹� B 鍊�锛岄伕瀹氶仼鐣�(d膩ng)?sh霉)?V 鍊�锛�
灏嶄竴鍊�(g猫)鎴栧咕鍊�(g猫)鐗瑰畾璩�(zh矛)閲忕殑闆㈠瓙閫�(j矛n)琛岄€ｇ簩(x霉)鐩�(ji膩n)娓�锛岃閷勬墍閬搁洟瀛愮殑闆㈠瓙寮�(qi谩ng)搴﹂毃鏅�(sh铆)闁撶殑璁婂寲
鏇茬窔锛屽嵆 SIM 璀滃湒锛孲IM 璀滃湒宄板舰鍙婂挤(qi谩ng)搴﹁垏琚脯绲勫垎鐨勮壊璀滃嘲瀹屽叏涓€鑷达紝鎿�(j霉) SIM 璀�
鍦栧畾閲�銆�
7锛嶦xternal Standard Method锛氬妯�(bi膩o)娉曪紝鐢ㄧ磾鐗╄唱(zh矛)閰嶅埗涓€绯诲垪涓嶅悓婵冨害鐨勬(bi膩o)婧�(zh菙n)瑭︽ǎ锛屽湪涓€
瀹氱殑鑹茶瓬姊濅欢涓嬫簴(zh菙n)纰哄畾閲忛€�(j矛n)妯ｏ紝娓畾宄伴潰绌嶏紙鎴栧嘲楂橈級锛岀躬鍒舵(bi膩o)婧�(zh菙n)鏇茬窔銆傚湪瀹屽叏鐩稿悓
鐨勮壊璀滄浠朵笅灏嶆ǎ鍝侀€�(j矛n)琛屾脯瀹�锛屾牴鎿�(j霉)鎵€寰楃殑宄伴潰绌嶏紙鎴栧嘲楂橈級锛屽付鍏ユ洸绶氭眰鍑鸿娓祫
鍒嗙殑鍚噺銆�
9
8锛嶱yrogen锛氱啽鍘�锛岃棩鍝佷腑鍚湁鐨勮兘寮曡捣楂旀韩鍗囬珮鐨勯洔璩�(zh矛)銆�
浜岋紟濉┖椤岋紙鏈鍖呮嫭 1-6 椤�锛屾瘡绌� 1.5 鍒�锛屽叡 30 鍒嗭級銆�
1锛庝腑鍦嬭棩鍏稿緸 2005 骞寸増璧峰垎鐐轰竴閮�銆佷簩閮ㄥ拰涓夐儴锛屽叾涓涓夐儴鏀惰級 鐢熺墿鍒跺搧 銆傝棩
鍏歌(gu墨)瀹氾細鈥滅ū瀹氣€濇槸鎸囨簴(zh菙n)纰鸿嚦鎵€绋遍噸閲忕殑 鐧惧垎 涔嬩竴锛涒€滅簿瀵嗙ū瀹氣€濇槸鎸囨簴(zh菙n)纰鸿嚦鎵€绋卞彇
閲嶉噺鐨� 鍗冨垎 涔嬩竴銆�
2锛庨噸姘寲鍙嶆噳(y墨ng)鐐� 鍒嗗瓙 鍙嶆噳(y墨ng)锛屽弽鎳�(y墨ng)閫熷害杓� 鎱� 锛屽線寰€鍔犲叆閬╅噺 婧村寲閴€ 浠ュ姞蹇�
鍙嶆噳(y墨ng)閫熷害銆傜偤浜嗛伩鍏嶆淮瀹氶亷绋嬩腑浜炵閰告彯鐧�(f膩)鍜屽垎瑙�锛屾淮瀹氭檪(sh铆)鍏堝皣婊村畾绠″皷绔� 鎻掑叆
娑查潰涓� 2/3 铏� 锛屼竴娆″皣澶ч儴鍒嗕簽纭濋吀閳夋淮瀹氭恫鍦ㄦ敧鎷屾浠朵笅杩呴€熷姞鍏ヤ娇鍏剁洝蹇弽
鎳�(y墨ng)銆傜劧鍚庡皣婊村畾绠″皷绔� 鎻愬嚭 锛岀敤灏戦噺姘存穻娲楀皷绔�锛屽啀绶╃珐婊村畾銆�
3锛庡湪姘翠腑锛岄珮姘吀鍜岄菇閰搁兘琚潎鍖栧埌H3O
+
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6锛庤壊璀滄祦鍑烘洸绶氱殑鎰忕京鍦ㄤ簬锛氳壊璀滃嘲鏁�(sh霉)琛ㄦ槑 妯ｅ搧涓墍鍚祫鍒嗙殑鏈€灏戞暩(sh霉)閲� 锛涙牴鎿�(j霉)鑹茶瓬
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閬告搰椤岀瓟椤屽崱锛�
椤岃櫉(h脿o) 1 2 3 4 5 6 7 8
绛旀 A C B B D C B B
1锛庤嫰椐㈠櫥鍡钘ョ墿鏄撹姘у寲锛岄€欐槸鍥�?y脿n)妞�?锛夌殑绶ｆ晠
A. 浣庡児(ji脿)鎱�(t脿i)鐨勭～鍏冪礌 B. 鐠�(hu谩n)涓� N 鍘熷瓙 C. 鍋�(c猫)閺堣剛鑲兒
D. 鍋�(c猫)閺堜笂鐨勯沟绱犲師瀛� E. 钂界挵(hu谩n)绲�(ji茅)妲�(g貌u)
2锛庣敤闈炴按婊村畾娉曟脯瀹氱敓鐗╁牽姘沟閰搁菇鏅�(sh铆)锛岄爤鍔犲叆閱嬮吀姹烇紝鍏剁洰鐨勬槸锛� 锛�
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D. 娑堥櫎寰噺姘村垎褰遍熆 E. 澧炲姞鍫挎€�
3锛庢槗纰冲寲鐗╂槸鎸囷紙 锛�
A. 钘ョ墿涓瓨鍦ㄧ殑鏈夎壊闆滆唱(zh矛)
B. 钘ョ墿涓亣 H2SO4 鏄撶⒊鍖栨垨鏄撴哀鍖栬€屽憟鑹茬殑寰噺鏈夋(j墨)闆滆唱(zh矛)
C. 钘ョ墿涓亣 H2SO4 鏄撶⒊鍖栨垨鏄撴哀鍖栬€屽憟鑹茬殑寰噺鐒℃(j墨)闆滆唱(zh矛)
D. 鏈夋(j墨)姘у寲鐗�
E. 纭吀鐏板垎
4锛庤儍寰�(f霉)搴蜂腑妾㈡煡浜岃嫰缇ュ熀涔欓吀鐨勬柟娉曞涓嬶細鍙栨湰鍝� 0.5g锛岄吀鎬т笅鐢ㄤ箼閱氭彁鍙栧悗钂稿共锛�
娈�?ji膩n)顝炶劷o姘翠箼閱� 10mL 婧惰В鍚庯紝鍦� 258nm 娉㈤暦铏曟脯瀹氬惛鏀跺害锛屼笉寰楄秴閬� 0.02銆傛眰鑳�
寰�(f霉)搴蜂腑浜岃嫰缇ュ熀涔欓吀鐨勯檺閲忥紙浠ョ櫨鍒嗚〃绀�锛屼簩鑻茎鍩轰箼閰稿湪 258nm 娉㈤暦铏曠殑 E1cm
1%
=19.7锛夛紙 锛�
A. 0. 2% B. 0.02% C. 0.1% D. 0.01% E. 0.3%
10
5锛庨棞(gu膩n)浜庨樋鍙稿尮鏋楃殑鍏╂婊村畾娉�锛屼笅闈㈠摢涓€绋棥杩版槸姝ｇ⒑鐨勶紙 锛�
A. 绗竴姝ユ淮瀹氭槸鐐轰簡涓拰鎵€鏈夌殑閰�锛屽惈閲忎互鍏╂涓ǎ鍝佺附娑堣€楃殑纭吀婊村畾鍔戦噺瑷�(j矛)绠�銆�
B. 绗竴姝ユ淮瀹氭槸鐐轰簡娑堥櫎骞叉摼锛屽惈閲忎互鍏╂婊村畾娑堣€楃殑姘哀鍖栭垑婊村畾鍔戦噺鐨勫樊鍊艰▓(j矛)
绠�銆�
C. 绗竴姝ユ淮瀹氭槸鐐轰簡姘磋В妯ｅ搧锛屽惈閲忎互绗簩姝ユ秷鑰楃殑姘哀鍖栭垑婊村畾鍔戦噺瑷�(j矛)绠�銆�
D锛庣涓€姝ユ淮瀹氭槸鐐轰簡涓拰鎵€鏈夌殑閰�锛屽惈閲忎互绌虹櫧瑭﹂(y脿n)鑸囩浜屾娑堣€楃殑纭吀婊村畾鍔戦噺
宸▓(j矛)绠椼€�
E锛庣涓€姝ユ淮瀹氭槸鐐轰簡涓拰鎵€鏈夌殑閰�锛屽惈閲忎互绌虹櫧瑭﹂(y脿n)鑸囩浜屾娑堣€楃殑姘哀鍖栭垑婊村畾
鍔戦噺宸▓(j矛)绠�銆�
6锛庣簿瀵嗛噺鍙栭菇閰告櫘榄崱鍥犳敞灏勬恫锛堣(gu墨)鏍肩偤 2ml鈭�40mg)13.64ml锛屽弮鐓ф案鍋滄淮瀹氭硶锛屽湪
15锝�20鈩冩淮瀹�锛屾秷鑰椾簽纭濋吀閳夋淮瀹氭恫(0.0492mol锛廘)20.00ml銆傛瘡 lml 浜炵閰搁垑婊�
瀹氭恫(0.0500mol锛廘)鐩哥暥(d膩ng)浜� 13.64mg 鐨勯菇閰告櫘榄崱鍥�銆傚墖妯�(bi膩o)绀洪噺鐨勭櫨鍒嗗惈閲忕偤
锛� 锛�
A. 100锛� B. 99.95锛� C. 98.40锛� D. 102.0锛� E. 101.6锛�
鍥涳紟澶氶爡(xi脿ng)閬告搰椤岋紙鏈鍖呮嫭 1-6 椤屽叡 6 鍊�(g猫)灏忛锛屾瘡灏忛 1.5 鍒�锛屽叡 9 鍒�銆傚湪姣忓皬椤岀郸鍑虹殑
鍥涘€�(g猫)閬搁爡(xi脿ng)涓�锛屾湁澶氬€�(g猫)绗﹀悎椤岀洰瑕佹眰锛屾妸鎵€閬搁爡(xi脿ng)鍓嶇殑瀛楁瘝濉湪绛旈鍗＄浉鎳�(y墨ng)鐨勫簭铏�(h脿o)鍏�(n猫i)锛�銆�
閬告搰椤岀瓟椤屽崱锛�
椤岃櫉(h脿o) 1 2 3 4 5 6 7 8 9 10
绛旀 BE ACD ABE ABC BC ADE ADE BCE BC BDE
1锛庡皪缍敓绱� E 閼掑垾瀵�(sh铆)椹�(y脿n)鏁樿堪姝ｇ⒑鐨勬槸锛� 锛�
A. 纭濋吀鍙嶆噳(y墨ng)涓董鐢熺礌 E 姘磋В鐢熸垚鐢熻偛閰氶’姗欑磪鑹�銆�
B. 纭濋吀鍙嶆噳(y墨ng)涓董鐢熺礌 E 姘磋В鐐何� -鐢熻偛閰氬悗锛屽張琚哀鍖栬€岄’姗欑磪鑹�銆�
C. 缍敓绱� E 鐒℃按涔欓唶婧舵恫鐒＄传澶栧惛鏀躲€�
D. FeCl3-鑱�(li谩n)鍚″暥鍙嶆噳(y墨ng)涓�锛孎(xi脿n)e
3+
鑸囪伅(li谩n)鍚″暥鐢熸垚绱呰壊閰嶉洟瀛愩€�
E. FeCl3-鑱�(li谩n)鍚″暥鍙嶆噳(y墨ng)涓�锛孎(xi脿n)e
2+
鑸囪伅(li谩n)鍚″暥鐢熸垚绱呰壊閰嶉洟瀛愩€�
2锛庨粌楂旈叜鍦ㄩ吀鎬ф憾娑蹭腑鍙垏涓嬪垪鍝簺瑭﹀姂鍙嶆噳(y墨ng)鍛堣壊锛� 锛�
A. 2,4-浜岀鍩鸿嫰鑲� B. 涓夋隘鍖栭惖 C. 纭吀鑻偧
D. 鐣扮厵鑲� E. 鍥涙爱鍞戦菇
3锛庣鍚堝洓姘攽姣旇壊娉曟脯瀹氱斁楂旀縺绱犺棩鐗╃殑姊濅欢鐐猴紙 锛�
A. 鍦ㄥ婧垨 30鈩冩亽婧浠朵笅椤壊銆�
B. 鐢ㄩ伩鍏夊鍣ㄥ苟缃簬鏆楄檿椤壊銆�
C. 鍔犲叆瑭﹀姂鍚庡彲浠ュ線瀹瑰櫒涓厖鍏ユ哀姘�銆�
D. 姘撮噺澧炲ぇ鑷� 5%浠ヤ笂锛屼娇鍛堣壊閫熷害鍔犲揩銆�
E. 鏈€甯搁噰鐢ㄦ矮姘у寲鍥涚敳鍩鸿兒鐐哄牽鍖栬│鍔�銆�
4锛庨潚闇夌礌鍏锋湁涓嬪垪鍝鎬ц唱(zh矛)锛� 锛�
A. 鍚湁鎵嬫€х⒊锛屽叿鏈夋棆鍏夋€�銆�
B. 鍒嗗瓙涓殑鐠�(hu谩n)鐙€閮ㄥ垎鐒＄传澶栧惛鏀讹紝浣嗗叾鍋�(c猫)閺堥儴鍒嗘湁绱鍚告敹銆�
C. ?-鍏�(n猫i)閰拌兒鐠�(hu谩n)鍦ㄩ吀銆佸牽銆侀潚闇夌礌閰�銆佹煇浜涢噾灞洟瀛愮殑浣滅敤涓�锛屽彲浣� ?-鍏�(n猫i)閰拌兒鐠�(hu谩n)闁嬬挵(hu谩n)
鎴栫櫦(f膩)鐢熷垎瀛愰噸鎺�锛岃€屽け鍘绘姉鑿屼綔鐢�銆�
D. 姣嶆牳鏄敱 ?-鍏�(n猫i)閰拌兒鐠�(hu谩n)鍜屼簩姘櫥鍡挵(hu谩n)绲勬垚鐨勯洐闆滅挵(hu谩n)銆�
E锛庡叿鏈夊牽鎬�锛屼笉鑳借垏鐒℃(j墨)閰稿舰鎴愰菇
5锛庡姞鍏� NaOH 瑭︽恫鍔犵啽鍚庢斁鍑哄牽鎬ф埃楂旂殑钘ョ墿鏈夛紙 锛�
11
A. 鑻敳閰搁垑 B. 灏煎彲鍓庣背 C. 鐣版垔宸存瘮濡�
D. 涓欑：鑸� E. 鍥涚挵(hu谩n)绱�
6锛庨潪姘存憾娑叉淮瀹氭硶娓畾宸存瘮濡ラ钘ョ墿鍚噺鏅�(sh铆)锛屼笅闈㈠摢浜涙浠跺彲閲囩敤锛� 锛�
A. 浜岀敳鍩虹敳閰拌兒鐐烘憾鍔� B. 鍐伴唻閰哥偤婧跺姂 C. 楂樻隘閰哥偤婊村畾鍔�
D. 鐢查唶閳夌偤婊村畾鍔� E. 楹濋鑽夐厷钘�(l谩n)鐐烘寚绀哄姂
7锛庛€婁腑鍦嬭棩鍏搞€�(2005 骞寸増)瑕�(gu墨)瀹氬悇鍝佺ó闋�(xi脿ng)涓嬬殑 HPLC 姊濅欢涓�锛屼笉寰椾换鎰忔敼璁婄殑鎳�(y墨ng)鐐�
A. 娴佸嫊(d貌ng)鐩哥祫鎴� B. 娴佸嫊(d貌ng)鐩稿悇绲勫垎鐨勬瘮渚� C. 鍥哄畾鐩哥殑鐗岃櫉(h脿o)
D. 鍥哄畾鐩哥殑绋 E. 妾㈡脯鍣ㄩ鍨�
8锛庢姉鐢熺礌娲绘€т互鏁堝児(ji脿)鍠綅琛ㄧず锛屽畠鏄寚锛� 锛�
A. 姣忔鍗囨垨姣忓厠涓惈鏈夋煇绋姉鐢熺礌鐨勬湁鏁堟垚鍒嗙殑澶氬皯
B. 姣忔鍗囨垨姣忔鍏嬩腑鍚湁鏌愮ó鎶楃敓绱犵殑鏈夋晥鎴愬垎鐨勫灏�
C. 鐢ㄥ柈浣� u 琛ㄧず
D. 鐢ㄦ鍏� mg 琛ㄧず
E. 鍚勭ó鎶楃敓绱犵殑鏁堝児(ji脿)鍩烘簴(zh菙n)鏄汉鐐鸿(gu墨)瀹氱殑
9锛庡湪鐢熺墿鍒╃敤搴﹀拰鐢熺墿绛夋晥鎬ц│椹�(y脿n)涓�锛岄棞(gu膩n)浜庣敓鐗╂ǎ鍝佷腑钘ョ墿鍙婂叾浠ｈ瑵鐢�(ch菐n)鐗╁畾閲忓垎鏋愭柟
娉�锛屾纰虹殑闂¤堪鏄紙 锛�
A. 鍒嗘瀽鏂规硶鐨勮€愮敤鎬у拰闈堟晱搴︽槸鎴愬姛鐨勯棞(gu膩n)閸�銆�
B. 鍒嗘瀽鏂规硶鐨勫皥灞€у拰闈堟晱搴︽槸鎴愬姛鐨勯棞(gu膩n)閸�銆�
C. 棣栭伕鑹茶瓬娉�锛屼竴鑸噳(y墨ng)閲囩敤鍏�(n猫i)妯�(bi膩o)娉曞畾閲�銆�
D. 棣栭伕鍏夎瓬娉�锛屼竴鑸噳(y墨ng)閲囩敤澶栨(bi膩o)娉曞畾閲�銆�
E锛庨閬稿閲忓垎鏋愭硶銆�
10锛庝互涓嬭〃绀鸿壊璀滀繚鐣欏€肩殑鍙冩暩(sh霉)鏈夛紙 锛�
A. 宄板 B. Kovats 鎸囨暩(sh霉) C. 宄伴珮 D. 瑾�(di脿o)鏁翠繚鐣欐檪(sh铆)闁� E.淇濈暀
鏅�(sh铆)闁�
浜旓紟瑷�(j矛)绠楅锛堟湰椤屽叡 1 椤岋紝10 鍒嗭級銆�
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鐗囬噸 0.5146g)锛屽姞绋€纭吀 5ml锛屾尟鎼栨暩(sh霉)鍒嗛悩浣垮挅鍟″洜婧惰В锛屾烤閬�锛屾烤娑茬疆 50ml 閲忕摱
涓�銆傛烤鍣ㄨ垏婵炬福鐢ㄦ按娲楁粚 3 娆★紝姣忔 5ml锛屽悎骞舵烤娑茶垏娲楁恫锛岀簿瀵嗗姞绱勭偤 0.1mol/L
鐨勭婊村畾娑� 25ml锛岀敤姘寸█閲嬭嚦鍒诲害锛屾悥鍕�銆傚湪绱� 25鈩冮伩鍏夋斁 15 鍒嗛悩锛屾烤閬�锛屾鍘�
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鍔犳穩绮夋寚绀哄姂绻肩簩(x霉)婊村畾鑷宠棈(l谩n)鑹叉秷澶�锛屾秷鑰楁淮瀹氭恫 12.00ml銆傚皣婊村畾绲�(ji茅)鏋滅敤绌虹櫧瑭﹂(y脿n)鏍�
姝�锛屾秷鑰楁淮瀹氭恫 21.50ml銆傛眰鍜栧暋鍥犳(bi膩o)绀洪噺鐨勭櫨鍒嗗惈閲�銆�(鎻愮ず锛氣憼鍙嶆噳(y墨ng)鎽╃埦姣旓細鍜栧暋
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锛庤В锛�102.7%
鍏紟鍟忕瓟椤岋紙鏈鍖呮嫭 1-6 椤�锛屽叡 50 鍒嗭級
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12
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3锛庣董鐢熺礌 A 鍘熸枡钘ョ殑娓畾鐐轰粈涔堥噰鐢ㄤ笁榛�(di菐n)鏍℃娉�锛屽叾娓畾鍘熺悊鏄粈涔�锛熶腑鍦嬭棩鍏告敹杓夌殑绗�
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