|
鍙嬫儏鎻愮ず锛氭湰绔欐彁渚涘叏鍦�400澶氭墍楂樼瓑闄㈡牎鎷涙敹纰╁＋銆佸崥澹爺绌剁敓鍏ュ(xu茅)鑰冭│姝峰勾鑰冪爺鐪熼銆佽€冨崥鐪熼銆佺瓟妗�锛岄儴鍒嗗(xu茅)鏍℃洿鏂拌嚦2012骞达紝2013骞�锛涘潎鎻愪緵鏀惰不涓嬭級銆� 涓嬭級娴佺▼锛� 鑰冪爺鐪熼 榛炴搳鈥�鑰冪爺瑭﹀嵎鈥濃€濅笅杓�; 鑰冨崥鐪熼 榛炴搳鈥�鑰冨崥瑭﹀嵎搴�鈥� 涓嬭級
2017 骞村啀鐢熼啱(y墨)瀛�(xu茅)灏堟キ(y猫)纰╁＋鐮旂┒鐢熷垵瑭︾鐩€冭│澶х侗
鍒嗗瓙鐢熺墿瀛�(xu茅)锛�836锛夎€冭│澶х侗
鍒嗗瓙鐢熺墿瀛�(xu茅)鏄毃鍗楀ぇ瀛�(xu茅)鍐嶇敓閱�(y墨)瀛�(xu茅)灏堟キ(y猫)纰╁＋鐮旂┒鐢熷叆瀛�(xu茅)鑰冭│鐨勭鐩箣涓€锛岋紝涓�
瑕侀珨鐝�(xi脿n)鐢熺墿瀛�(xu茅)銆佸熀绀�(ch菙)閱�(y墨)瀛�(xu茅)鍙婅嚚搴婇啱(y墨)瀛�(xu茅)鐭ヨ瓨缇ょ殑浜ゅ弶鍦ㄥ啀鐢熼啱(y墨)瀛�(xu茅)闋�(l菒ng)鍩熺殑鎳�(y墨ng)鐢ㄣ€傜偤浣�
鑰冪敓鏄庣⒑鑰冭│鍏�(n猫i)瀹瑰拰鐭ヨ瓨瑕侀粸锛屾妸鎻¤€冭│鐨勮寖鍦嶅拰瑕佹眰锛岀壒绶ㄥ姝よ€冭│澶х侗浣滅偤
鍙冭€冦€傚畠鐨勮⿻鍍规婧栨槸楂樼瓑瀛�(xu茅)鏍″劒(y艒u)绉€鏈鐣㈡キ(y猫)鐢熻兘閬斿埌鐨勫強鏍兼垨鍙婃牸浠ヤ笂姘村钩锛�
浠ヤ繚璀夎閷勫彇鑰呭叿鏈夊熀鏈殑鍒嗗瓙鐢熺墿瀛�(xu茅)鐭ヨ瓨鑰屾湁鍒╀簬鎴戞牎鍦ㄩ寗鍙栨檪鎿囧劒(y艒u)閬告嫈銆�
涓€銆佽€冭│瑕佹眰
1銆佽姹傛帉鎻″垎瀛愮敓鐗╁(xu茅)鐨勫熀鏈蹇�锛�
2銆佽姹傛帉鎻″垎瀛愮敓鐗╁(xu茅)鐨勫熀鏈師鐞�锛�
3銆佽姹傜郴绲�(t菕ng)鐨勬帉鎻″垎瀛愮敓鐗╁(xu茅)鐨勫父鐢ㄦ妧琛�(sh霉)鍜屾柟娉�锛岃兘澶犲氨鏌愪竴鍟忛瑷�(sh猫)瑷堝嚭瀵﹂
鏂规銆�
浜屻€佽│鍗风祼(ji茅)妲�(g貌u)
鍩虹(ch菙)鐭ヨ瓨鍗� 40%锛岀稖鍚堛€佸垎鏋愰鍗� 40%锛屽壍(chu脿ng)閫犳€ф€濈董椤屽崰 20%銆傝│鍗蜂富瑕�
鐢卞悕瑭炶В閲�銆佸～绌洪銆佺啊绛旈銆佺稖鍚堝垎鏋愰绛夌祫鎴�銆�
涓�銆佽€冭│鏂瑰紡鍜屾檪闁撻檺鍒�
鑰冭│鏂瑰紡鐐虹瓎瑭�锛屾檪闁撲笁灏忔檪銆�
鍥�銆佽€冩煡瑕侀粸
锛堜竴锛塂NA
1銆丏NA 鐨勭祼(ji茅)妲�(g貌u)
DNA 鐨勬(g貌u)鎴�锛孌NA 鐨勪竴绱氱祼(ji茅)妲�(g貌u)銆佷簩绱氱祼(ji茅)妲�(g貌u)銆侀珮绱氱祼(ji茅)妲�(g貌u)
2銆丏NA 鐨勫京(f霉)鍒�
DNA 鐨勫崐淇濈暀寰�(f霉)鍒讹紝寰�(f霉)鍒惰捣榛�銆佹柟鍚戝拰閫熷害锛屽京(f霉)鍒剁殑骞剧ó涓昏鏂瑰紡
3銆佸師鏍哥敓鐗╁拰鐪熸牳鐢熺墿 DNA 寰�(f霉)鍒剁壒榛�
鍘熸牳鐢熺墿 DNA 寰�(f霉)鍒剁壒榛烇紝鐪熸牳鐢熺墿 DNA 寰�(f霉)鍒剁壒榛�锛孌NA 鐨勫京(f霉)鍒惰(di脿o)鎺�
4銆丏NA 鐨勪慨寰�(f霉)
鍥涚ó淇京(f霉)鏂瑰紡
5銆丏NA 鐨勮綁(zhu菐n)搴�
杞�(zhu菐n)搴у瓙鐨勫垎椤炲拰绲�(ji茅)妲�(g貌u)鐗瑰緛锛岃綁(zhu菐n)搴ф鍒�锛岃綁(zhu菐n)搴т綔鐢ㄧ殑閬哄偝瀛�(xu茅)鏁堟噳(y墨ng)锛岀湡鏍哥敓鐗╃殑
杞�(zhu菐n)搴у瓙
锛堜簩锛夌敓鐗╀俊鎭殑鍌抽仦锛堜笂锛夆€斺€斿緸 DNA 鍒� RNA
1銆丷NA 鐨勮綁(zhu菐n)閷�
杞�(zhu菐n)閷勭殑鍩烘湰閬庣▼锛岃綁(zhu菐n)閷勬鍣ㄧ殑涓昏鎴愬垎
2銆佸暉鍕曞瓙鑸囪綁(zhu菐n)閷勮捣濮�
鍟熷嫊瀛愮殑鍩烘湰绲�(ji茅)妲�(g貌u)锛屽暉鍕曞瓙鐨勮瓨鍒�锛岄叾鑸囧暉鍕曞瓙鐨勭祼(ji茅)鍚�锛�-10 鍗€(q奴)鍜�-35 鍗€(q奴)鐨�
鏈€浣抽枔璺�锛屽寮峰瓙鍙婂叾鍔熻兘锛岀湡鏍哥敓鐗╁暉鍕曞瓙灏嶈綁(zhu菐n)閷勭殑褰遍熆
3銆佸師鏍哥敓鐗╄垏鐪熸牳鐢熺墿 mRNA 鐨勭壒寰佹瘮杓�
鍘熸牳鐢熺墿 mRNA 鐨勭壒寰�锛岀湡鏍哥敓鐗� mRNA 鐨勭壒寰�
4銆佺祩姝㈠拰鎶楃祩姝�
涓嶄緷璩翠簬 蟻 鍥犲瓙鐨勭祩姝�锛屼緷璩翠簬 蟻 鍥犲瓙鐨勭祩姝紝鎶楃祩姝�
5銆佸収(n猫i)鍚瓙鐨勫壀鎺ャ€佺法杓強鍖栧(xu茅)淇＞
RNA 涓殑鍏�(n猫i)鍚瓙锛孯NA 鐨勫壀鎺�锛孯NA 鐨勭法杓拰鍖栧(xu茅)淇＞
锛堜笁锛夌敓鐗╀俊鎭殑鍌抽仦锛堜笅锛夆€斺€斿緸 DNA 鍒拌泲鐧借唱(zh矛)
1銆侀伜鍌冲瘑纰�
涓夎伅(li谩n)瀛愬瘑纰煎強鍏剁牬璀�锛岄伜鍌冲瘑纰肩殑鎬ц唱(zh矛)
2銆乼RNA
tRNA 鐨勭祼(ji茅)妲�(g貌u)銆佸姛鑳藉強绋锛屾皑閰�-tRNA 鍚堟垚閰�
3銆佹牳绯栭珨
鏍哥硸楂旂殑绲�(ji茅)妲�(g貌u)锛宺RNA锛屾牳绯栭珨鐨勫姛鑳�
4銆佽泲鐧借唱(zh矛)鍚堟垚鐨勭敓鐗╁(xu茅)姗熷埗
姘ㄥ熀閰哥殑娲诲寲锛岃偨閺堢殑璧峰銆佸欢浼稿拰绲傛锛岃泲鐧借唱(zh矛)鍓嶉珨鐨勫姞宸�锛岃泲鐧借唱(zh矛)鍚堟垚
鎶戝埗鍔�锛孯NA 鍒嗗瓙鍦ㄧ敓鐗╅€插寲涓殑鍦颁綅
5銆佽泲鐧借唱(zh矛)閬嬭綁(zhu菐n)姗熷埗
缈昏-閬嬭綁(zhu菐n)鍚屾姗熷埗锛岀炕璀悗鐨勯亱杞�(zhu菐n)姗熷埗锛屾牳瀹氫綅铔嬬櫧鐨勯亱杞�(zhu菐n)姗熷埗锛岃泲鐧借唱(zh矛)
鐨勯檷瑙�
锛堝洓锛夊垎瀛愮敓鐗╁(xu茅)鐮旂┒娉�
1銆丏NA 鎿嶄綔鎶€琛�(sh霉)
鏍搁吀鐨勫垎闆�銆佹彁绱斿拰瀹氶噺娓畾鐨勬柟娉曪紝鏍搁吀鐨勫嚌鑶犻浕娉�锛屽垎瀛愰洔浜�锛岀窗鑿岃綁(zhu菐n)
鍖�锛屾牳鑻烽吀搴忓垪鍒嗘瀽锛屽熀鍥犳摯澧�锛孌NA 鑸囪泲鐧借唱(zh矛)鐩镐簰浣滅敤鐮旂┒
2銆佸熀鍥犲厠闅嗙殑涓昏杓夐珨绯荤当(t菕ng)
璩�(zh矛)绮� DNA 鍙婂叾鍒嗛洟绱斿寲锛岄噸瑕佺殑澶ц吀妗胯弻璩�(zh矛)绮掕級楂�锛屛� 鍣弻楂旇級楂旓紝鏌柉
璩�(zh矛)绮掕級楂�锛宲Bluescript 鍣弻楂旇級楂�
3銆佸熀鍥犵殑鍒嗛洟鍜岄憭瀹�
DNA 鐗囨鐨勭敘(ch菐n)鐢熷拰鍒嗛洟锛岄噸绲勯珨 DNA 鍒嗗瓙鐨勬(g貌u)寤�锛宑DNA 鍩哄洜鐨勫厠闅�锛屽厠
闅嗗熀鍥犵殑鍒嗛洟
锛堜簲锛夊熀鍥犵殑琛ㄩ仈鑸囪(di脿o)鎺э紙涓婏級鈥斺€斿師鏍稿熀鍥犺〃閬旇(di脿o)鎺фā寮�
1.鍘熸牳鍩哄洜琛ㄩ仈瑾�(di脿o)鎺х附璜�
鍘熸牳鍩哄洜瑾�(di脿o)鎺ф鍒剁殑椤炲瀷鍜岀壒榛烇紝寮卞寲瀛愬皪鍩哄洜娲绘€х殑褰遍熆锛岄檷瑙ｇ墿灏嶅熀鍥�
娲绘€х殑瑾�(di脿o)绡€(ji茅)锛岀窗鑿岀殑鎳�(y墨ng)鎬ュ弽鎳�(y墨ng)
2.涔崇硸鎿嶇副瀛愯垏璨犳帶瑾樺皫(d菐o)绯荤当(t菕ng)
鎿嶇副瀛愭ā鍨嬪強褰遍熆鍥犲瓙锛宭ac 鎿嶇副瀛� DNA 鐨勮(di脿o)鎺у崁(q奴)鍩熲€斺€擯銆丱 鍗€(q奴)
3銆佽壊姘ㄩ吀鎿嶇副瀛愯垏璨犳帶闃婚亸绯荤当(t菕ng)
trp 鎿嶇副瀛愮殑闃婚亸绯荤当(t菕ng)锛屽急鍖栧瓙鑸囧墠灏�(d菐o)鑲�
4銆佸叾浠栨搷绺卞瓙
鍗婁钩绯栨搷绺卞瓙锛岄樋鎷変集绯栨搷绺卞瓙
6銆佽綁(zhu菐n)閷勫悗瑾�(di脿o)鎺�
缈昏璧峰鐨勮(di脿o)鎺�锛岀█鏈夊瘑纰煎瓙灏嶇炕璀殑褰遍熆锛岄噸鐤婂熀鍥�?q奴)唯顓恎鐨勫奖闊�锛宲oly(A)
灏嶇炕璀殑褰遍熆锛岀炕璀殑闃婚亸锛屾牳鑻烽吀姘村钩灏嶇炕璀殑褰遍熆
锛堝叚锛夊熀鍥犵殑琛ㄩ仈鑸囪(di脿o)鎺э紙涓嬶級鈥斺€旂湡鏍稿熀鍥犺(di脿o)鎺х殑涓€鑸(gu墨)寰�
1銆佺湡鏍哥敓鐗╁熀鍥犵殑鍩哄洜绲�(ji茅)妲�(g貌u)鑸囪綁(zhu菐n)閷勬椿鎬�
鍩哄洜瀹舵棌锛岀湡鏍稿熀鍥犵殑鏂疯绲�(ji茅)妲�(g貌u)锛岀湡鏍哥敓鐗� DNA 姘村钩涓婄殑鍩哄洜琛ㄩ仈瑾�(di脿o)鎺�锛�
DNA 鐢插熀鍖栬垏鍩哄洜娲绘€х殑瑾�(di脿o)鎺�
2銆佺湡鏍稿熀鍥犵殑杞�(zhu菐n)閷�
3銆佸弽寮忎綔鐢ㄥ洜瀛�
DNA 璀樺垾鎴栫祼(ji茅)鍚堝煙锛岃綁(zhu菐n)閷勬椿鍖栫祼(ji茅)妲�(g貌u)鍩�
4銆佺湡鏍稿熀鍥犺綁(zhu菐n)閷勮(di脿o)鎺х殑涓昏妯″紡
铔嬬櫧璩�(zh矛)纾烽吀鍖�銆佷俊铏熻綁(zhu菐n)灏�(d菐o)鍙婂熀鍥犺〃閬�锛屾縺绱犲強鍏跺奖闊�锛岀啽婵€铔嬬櫧瑾樺皫(d菐o)鐨勫熀鍥�
琛ㄩ仈锛岄噾灞～铔嬬櫧鍩哄洜鐨勫閲嶈(di脿o)鎺�
5銆佸叾浠栨按骞充笂鐨勫熀鍥犺(di脿o)鎺�
RNA 鐨勫姞宸ユ垚鐔�锛岀炕璀按骞崇殑瑾�(di脿o)鎺�
锛堜竷锛夌柧鐥呰垏浜洪鍋ュ悍
1銆佽叓鐦よ垏鐧岀櫏
鍙嶈綁(zhu菐n)閷勭梾姣掕嚧鐧屽熀鍥�锛岀檶鍩哄洜鐨勫垎椤炪€佺敘(ch菐n)鐗╁拰琛ㄩ仈瑾�(di脿o)鎺�锛屽熀鍥犱簰浣滆垏鐧屽熀鍥�
琛ㄩ仈
2銆佷汉鍏嶇柅缂烘悕鐥呮瘨 HIV
HIV 鐥呮瘨绮掑瓙鐨勫舰鎱�(t脿i)绲�(ji茅)妲�(g貌u)鍜屽偝鏌擄紝HIV 鐨勬劅鏌撳強鑷寸梾姗熺悊锛岃壘婊嬬梾鐨勬不鐧傚強
闋�(y霉)闃�
3銆佷箼鍨嬭倽鐐庣梾姣� HBV
鑲濈値鐥呮瘨鐨勭矑瀛愮祼(ji茅)妲�(g貌u)
4銆佸熀鍥犳不鐧�
鍩哄洜娌荤檪鐨勬鍙叉部闈╋紝鍩哄洜娌荤檪涓殑鐥呮瘨杓夐珨锛岄潪鐥呮瘨杓夐珨
锛堝叓锛夊熀鍥犺垏鐧�(f膩)鑲�
1銆佸厤鐤珨绯荤櫦(f膩)鑲插強鍏嶇柅鐞冭泲鐧藉熀鍥犺〃閬�
鑴婃鍕曠墿鍏嶇柅绯荤当(t菕ng)锛孊 娣嬪反绱拌優銆乀 娣嬪反绱拌優锛屽厤鐤悆铔嬬櫧鐨勭祼(ji茅)妲�(g貌u)锛宭g 鍩哄洜
閲嶆帓锛屼富瑕佺祫绻旂浉瀹瑰京(f霉)鍚堥珨
2銆佹灉锠呯殑鑳氳儙鐧�(f膩)鑲�
鍗靛瓙鐧�(f膩)鑲�锛岃儦鑳庣櫦(f膩)鑲�
锛堜節锛夊熀鍥犵祫鍜屾瘮杓冨熀鍥犵祫瀛�(xu茅)
1銆佷汉椤炲熀鍥犵祫瑷堝妰
浜洪鍩哄洜绲勮▓鍔冪殑绉戝(xu茅)鎰忕京锛岄伜鍌冲湒锛岀墿鐞嗗湒锛岃綁(zhu菐n)閷勫湒锛屼汉椤炲熀鍥犵祫鐨勫簭鍒�
鍦�
2銆丏NA 鐨勯偿妲嶆硶搴忓垪鍒嗘瀽鎶€琛�(sh霉)
鍩哄洜绲� DNA 澶х墖鏂锋枃搴殑妲�(g貌u)寤�锛岄偿妲嶆硶鍩哄洜绲勫簭鍒楀垎鏋愭妧琛�(sh霉)鍙婂叾鏀硅壇
3銆佹瘮杓冨熀鍥犵祫瀛�(xu茅)鍙婂姛鑳藉熀鍥犵祫瀛�(xu茅)鐮旂┒
閫氶亷鍩哄洜绲勬暩(sh霉)鎿�(j霉)閫茶鍏ㄥ眬鎬у垎鏋愶紝鍩哄洜绲勬暩(sh霉)鎿�(j霉)鐨勬瘮杓冨垎鏋�锛屽姛鑳藉熀鍥犵祫瀛�(xu茅)鐮�
绌�
浜斻€佷富瑕佸弮鑰冩浉锛�
1銆佹湵鐜夎尝绛�.鐝�(xi脿n)浠ｅ垎瀛愮敓鐗╁(xu茅)锛堢涓夌増锛�.鍖椾含锛氶珮绛夋暀鑲插嚭鐗堢ぞ锛�2007.
2銆併€婂熀鍥� VIII銆嬶紙涓枃鐗堬級锛孊enjamin Lewin锛屼綑榫嶇瓑璀紝绉戝(xu茅)鍑虹増绀�锛�2005
鍏嶈铂鑱叉槑锛氭湰鏂囩郴杞�(zhu菐n)杓夎嚜缍�(w菐ng)绲�(lu貌)锛屽鏈変镜鐘�锛岃珛鑱�(li谩n)绯绘垜鍊戠珛鍗冲埅闄わ紝鍙︼細鏈枃鍍呬唬琛ㄤ綔鑰呭€嬩汉瑙€榛�锛岃垏鏈恫(w菐ng)绔欑劇闂�(gu膩n)銆傚叾鍘熷壍(chu脿ng)鎬т互鍙婃枃涓櫝杩版枃瀛楀拰鍏�(n猫i)瀹规湭缍�(j墨ng)鏈珯璀夊锛屽皪鏈枃浠ュ強鍏朵腑鍏ㄩ儴鎴栬€呴儴鍒嗗収(n猫i)瀹�銆佹枃瀛楃殑鐪熷鎬с€佸畬鏁存€�銆佸強鏅傛€ф湰绔欎笉浣滀换浣曚繚璀夋垨鎵胯锛岃珛璁€鑰呭儏浣滃弮鑰�锛屽苟璜嬭嚜琛屾牳瀵︾浉闂�(gu膩n)鍏�(n猫i)瀹�銆�
|
鏂囩珷鎼滅储
鎮ㄧ従(xi脿n)鍦ㄧ殑浣嶇疆锛� 
