鍙嬫儏鎻愮ず锛氭湰绔欐彁渚涘叏鍦�(gu贸)400澶氭墍楂樼瓑闄㈡牎鎷涙敹纰╁+銆佸崥澹爺绌剁敓鍏ュ(xu茅)鑰冭│姝峰勾鑰冪爺鐪熼銆佽€冨崥鐪熼銆佺瓟妗堬紝閮ㄥ垎瀛�(xu茅)鏍℃洿鏂拌嚦2012骞�锛�2013骞�锛涘潎鎻愪緵鏀惰不(f猫i)涓嬭級銆� 涓嬭級娴佺▼锛� 鑰冪爺鐪熼 榛�(di菐n)鎿娾€�鑰冪爺瑭﹀嵎鈥濃€濅笅杓�; 鑰冨崥鐪熼 榛�(di菐n)鎿娾€�鑰冨崥瑭﹀嵎搴�(k霉)鈥� 涓嬭級
鍗椾含杈�(n贸ng)妤�(y猫)澶у(xu茅) 2018 骞寸ⅸ澹爺绌剁敓鍏ュ(xu茅)鑰冭│澶х侗 鈥滃垎瀛愮敓鐗╁(xu茅) 鈥濊绋嬪弮鑰冩浉(sh奴)濡備笅锛� 鍙冭€冩浉(sh奴)鐩� 銆婂垎瀛愰伜鍌冲(xu茅)銆嬬浜岀増锛屽涔冩仼涓荤法锛屽崡浜ぇ瀛�(xu茅)鍑虹増绀�锛� 1999 骞�銆� 鑰冭│澶х侗 鍒嗗瓙鐢熺墿瀛�(xu茅)鐧�(f膩)灞曞彶涓噸澶т簨浠跺強鍋氬嚭閲嶈璨㈢嵒(xi脿n)鐨勪汉鐗╁ 鍚嶃€� 鐢熺墿澶у垎瀛愮殑椤�(l猫i)鍨�銆佸寲瀛�(xu茅)绲勬垚銆佺祼(ji茅)妲�(g貌u)鍙婂叾鍔熻兘銆� 鍘熸牳鍜岀湡鏍哥敓鐗╂煋鑹查珨绲�(ji茅)妲�(g貌u)鐨勫熀鏈壒寰侊紝DNA 寰�(f霉)鍒剁殑鍒嗗瓙姗�(j墨) 鍒�锛屽熀鍥犵祫鍜屽熀鍥犵祫瀛�(xu茅)鐨勫熀鏈蹇靛強椤�(l猫i)鍨嬪拰鐮旂┒鏂规硶銆� DNA 鎼嶅偡銆佷慨寰�(f霉)鍜岄噸绲�锛屽寘鎷� DNA 鎼嶅偡鐨勫師鍥�銆侀(l猫i)鍨�銆佷慨寰�(f霉) 鍜岄噸绲勬(j墨)鍒�銆� 鍩哄洜琛ㄩ仈(d谩)鑸囪(di脿o)鎺�锛屽寘鎷熀鍥犺〃閬�(d谩)瑾�(di脿o)鎺х殑鐢熺墿瀛�(xu茅)鎰忕京銆佸熀鍥� 琛ㄩ仈(d谩)鐨勬湁搴忔€�銆佸収(n猫i)澶栫挵(hu谩n)澧冨洜绱犲皪(du矛)鍩哄洜琛ㄩ仈(d谩)鐨勫奖闊�銆佸熀鍥犺〃 閬�(d谩)瑾�(di脿o)鎺х殑绲勭箶绲�(ji茅)妲�(g貌u)銆佹牳灏忛珨鑸囧寲瀛�(xu茅)淇>鍦ㄥ熀鍥犺〃閬�(d谩)瑾�(di脿o)鎺т腑 鐨勪綔鐢�銆佽垏杞�(zhu菐n)閷勮(di脿o)鎺х浉闂�(gu膩n)鐨� DNA 鍜岃泲鐧借唱(zh矛)銆丏NA-铔嬬櫧璩�(zh矛)璀�(sh铆) 鍒ュ拰绲�(ji茅)鍚堢殑绲�(ji茅)妲�(g貌u)鐗瑰緛銆佸師鏍稿強鐪熸牳鍩哄洜杞�(zhu菐n)閷勮(di脿o)鎺фā寮忓強铔� 鐧借唱(zh矛)鍚堟垚閬�(gu貌)绋嬨€� 绱�(x矛)鑳炰俊铏�(h脿o)鍌冲皫(d菐o)锛屽寘鎷窗(x矛)鑳炰俊铏�(h脿o)鍌冲皫(d菐o)鐨勫熀鏈蹇点€佷俊铏�(h脿o)鍒嗗瓙 鐨勫垎椤�(l猫i)銆佺窗(x矛)鑳炶〃闈㈠彈楂旂殑鍒嗛(l猫i)鍜岀祼(ji茅)妲�(g貌u)鐗归粸(di菐n)銆佸湪绱�(x矛)鑳炰俊铏�(h脿o)鍌� 閬炰腑鐨勪綔鐢�銆乧AMP銆乧GMP銆両P3銆丏G銆丆a2+鍙� CaM 鍙婂彈楂旈叒 姘ㄩ吀铔嬬櫧婵€閰朵俊铏�(h脿o)鍌冲皫(d菐o)閫斿緫銆� 鍩哄洜鎿嶄綔鎶€琛�(sh霉)锛屽寘鎷垎瀛愬厠闅嗘搷浣滃父鐢ㄧ殑宸ュ叿閰剁殑鐗规€�銆� 鍒嗗瓙鍏嬮殕甯哥敤鐨� DNA 杓夐珨鐨勭壒榛�(di菐n)鍜岀敤閫斻€佸垎瀛愬厠闅嗙殑鍩烘湰 绋嬪簭銆佸厠闅嗗熀鍥犵殑鍒嗘瀽鏂规硶銆佸熀鍥犳暡闄ゅ拰瀹氶粸(di菐n)瑾樿畩鎶€琛�(sh霉)銆� 鍩哄洜绲勬枃搴�(k霉)鍜� cDNA 鏂囧韩(k霉)鐨勬(g貌u)寤烘柟娉曞拰鐢ㄩ€斻€� 鍒嗗瓙鐢熺墿瀛�(xu茅)甯哥敤鎶€琛�(sh霉)锛屽寘鎷牳閰稿拰铔嬬櫧璩�(zh矛)鐨勫嚌鑶犻浕娉筹紙鍘� 鐞嗐€佹柟娉�銆佺ó椤�(l猫i)鍜屽奖闊垮洜绱狅級銆丳CR锛堝師鐞�銆佺ó椤�(l猫i)鍜屾柟娉曪級銆� 鍒嗗瓙闆滀氦锛堝師鐞�銆佺ó椤�(l猫i)鍜屾柟娉曪級鍜� DNA 娓�(c猫)搴忥紙鍘熺悊銆佹柟娉曪級 妤靛叾鎳�(y墨ng)鐢ㄣ€� 妞嶇墿鍩哄洜宸ョ▼锛屽寘鎷鐗╄〃閬�(d谩)杓夐珨鐨勬(g貌u)寤恒€佹鐗╁熀鍥犺綁(zhu菐n)鍖� 鐨勫師鐞嗚垏鏂规硶銆佽綁(zhu菐n)鍖栫窗(x矛)鑳炵殑绡╅伕鑸囪綁(zhu菐n)鍩哄洜妞嶇墿鐨勯憭瀹氫互鍙� 妞嶇墿鍩哄洜宸ョ▼鐨勬噳(y墨ng)鐢�銆�
鍏嶈铂(z茅)鑱叉槑锛氭湰鏂囩郴杞�(zhu菐n)杓夎嚜缍�(w菐ng)绲�(lu貌)锛屽鏈変镜鐘�锛岃珛(q菒ng)鑱�(li谩n)绯绘垜鍊戠珛鍗冲埅闄わ紝鍙︼細鏈枃鍍呬唬琛ㄤ綔鑰呭€�(g猫)浜鸿榛�(di菐n)锛岃垏鏈恫(w菐ng)绔欑劇(w煤)闂�(gu膩n)銆傚叾鍘熷壍(chu脿ng)鎬т互鍙婃枃涓櫝杩版枃瀛楀拰鍏�(n猫i)瀹规湭缍�(j墨ng)鏈珯璀夊(sh铆)锛屽皪(du矛)鏈枃浠ュ強鍏朵腑鍏ㄩ儴鎴栬€呴儴鍒嗗収(n猫i)瀹�銆佹枃瀛楃殑鐪熷(sh铆)鎬�銆佸畬鏁存€с€佸強鏅�(sh铆)鎬ф湰绔欎笉浣滀换浣曚繚璀夋垨鎵胯锛岃珛(q菒ng)璁€鑰呭儏浣滃弮鑰冿紝骞惰珛(q菒ng)鑷鏍稿(sh铆)鐩搁棞(gu膩n)鍏�(n猫i)瀹�銆�
|