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鍙嬫儏鎻愮ず锛氭湰绔欐彁渚涘叏鍦�400澶氭墍楂樼瓑闄㈡牎鎷涙敹纰╁＋銆佸崥澹爺绌剁敓鍏ュ(xu茅)鑰冭│姝峰勾鑰冪爺鐪熼銆佽€冨崥鐪熼銆佺瓟妗�锛岄儴鍒嗗(xu茅)鏍℃洿鏂拌嚦2012骞达紝2013骞�锛涘潎鎻愪緵鏀惰不涓嬭級銆� 涓嬭級娴佺▼锛� 鑰冪爺鐪熼 榛炴搳鈥�鑰冪爺瑭﹀嵎鈥濃€濅笅杓�; 鑰冨崥鐪熼 榛炴搳鈥�鑰冨崥瑭﹀嵎搴�鈥� 涓嬭級
绗� 1 闋�锛屽叡 2 闋�
娴� 姹� 鐞� 宸� 澶� 瀛�(xu茅)
2018 骞寸ⅸ澹(xu茅)浣嶇爺绌剁敓鎷涚敓鑰冭│妤�(y猫)鍕�(w霉)瑾茶€冭│澶х侗
鑰冭│绉戠洰锛氬熀绀�(ch菙)鐢熺墿鍖栧(xu茅) 浠ｇ⒓锛�715
鑰冭│鍩烘湰瑕佹眰
绯荤当(t菕ng)鍦拌€冨療鑰冪敓鐞嗚В骞舵帉鎻＄敓鐗╁寲瀛�(xu茅)闋�(l菒ng)鍩熺殑鍩烘湰鐞嗚珫鍜屾妧琛�(sh霉)鐨勭啛绶寸▼搴�锛屼互
鍙婂皪鐢熺墿鍖栧(xu茅)闋�(l菒ng)鍩熺殑鐣跺墠鐮旂┒鐔遍粸鍜屾柊閫插睍鐨勪簡瑙ｇ▼搴�銆�
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鍖呮嫭绲�(ji茅)妲�(g貌u)鐢熺墿鍖栧(xu茅)銆佷唬璎濈敓鐗╁寲瀛�(xu茅)鍜屽垎瀛愮敓鐗╁(xu茅)涓夊€嬮儴鍒嗗湪鍏�(n猫i)鐨勭敓鐗╁寲瀛�(xu茅)銆�
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鑰冭│鍏�(n猫i)瀹�
1. 鐢熺墿澶у垎瀛愮殑绲�(ji茅)妲�(g貌u)鑸囧姛鑳斤紙绲�(ji茅)妲�(g貌u)鐢熺墿鍖栧(xu茅)锛�
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闆㈣垏绱斿寲锛涜偨鑸囪偨閸碉紝瀵¤偨鐨勭悊鍖栨€ц唱(zh矛)锛屽ぉ鐒舵椿鎬ц偨锛涜泲鐧借唱(zh矛)鐨勭祼(ji茅)妲�(g貌u)锛岃泲鐧借唱(zh矛)绲�(ji茅)
妲�(g貌u)鑸囧姛鑳界殑闂�(gu膩n)绯伙紱铔嬬櫧璩�(zh矛)鐨勫垎椤炲拰鐞嗗寲鎬ц唱(zh矛)锛岃泲鐧借唱(zh矛)鐨勫垎闆€€佺磾鍖栧拰鍒嗘瀽锛涜泲鐧�
璩�(zh矛)绲勫(xu茅)銆�
锛�2锛夋牳閰哥殑绲�(ji茅)妲�(g貌u)鑸囧姛鑳斤細鏍歌嫹閰哥殑绲�(ji茅)妲�(g貌u)鍜屾€ц唱(zh矛)锛涙牳閰哥殑鍖栧(xu茅)绲勬垚銆佺ó椤炲拰
鍔熻兘锛涙牳閰哥殑绲�(ji茅)妲�(g貌u)锛屾牳閰歌垏铔嬬櫧璩�(zh矛)鐨勭浉浜掍綔鐢�锛涘熀鍥�銆佸熀鍥犵祫鍜屽熀鍥犵祫瀛�(xu茅)鐨勬蹇碉紝
鏌撹壊楂旂殑绲�(ji茅)妲�(g貌u)锛涙牳閰哥殑鎬ц唱(zh矛)鍜屽垎闆㈠垎鏋�锛屾牳閰稿簭鍒楃殑娓畾銆�
锛�3锛夐叾瀛�(xu茅)锛氶叾鐨勫寲瀛�(xu茅)鏈唱(zh矛)鍜屽偓鍖栦綔鐢ㄧ壒榛烇紱閰剁殑鍒嗛銆佸懡鍚嶅拰娲诲姏娓畾锛�
閰剁殑鍌寲姗熺悊鍜岄叾娲绘€ц(di脿o)绡€(ji茅)锛涢叾鍕曞姏瀛�(xu茅)鍙冩暩(sh霉)鐨勬剰缇�锛涙牳閰剁殑绲�(ji茅)妲�(g貌u)鑸囧姛鑳�銆�
2. 鐗╄唱(zh矛)浠ｈ瑵鍙婅(di脿o)鎺э紙浠ｈ瑵鐢熺墿鍖栧(xu茅)锛�
锛�1锛変唬璎濈附璜栬垏鐢熺墿姘у寲锛氶珮鑳介嵉鑸囬珮鑳藉寲鍚堢墿锛涚敓鐗╂哀鍖栫壒榛炲拰鐢熺墿姘�
鍖栭珨绯伙紱姘у寲纾烽吀鍖栦綔鐢ㄥ強鍏舵鐞�銆�
锛�2锛夌硸椤炰唬璎濓細绯栭鐨勯叾淇冮檷瑙�锛涜憽钀勭硸鐨勭劇姘ч叺瑙ｅ拰鏈夋哀姘у寲鐨勭窗鑳炲畾
浣嶃€佷唬璎濋€斿緫銆佽兘閲忚畩鍖�銆佺敓鐗╁(xu茅)鎰忕京鍙婂叾瑾�(di脿o)鎺ф鐞�锛岀７閰告垔绯栭€斿緫鐨勭窗鑳炲畾浣�銆�
涓昏鍙嶆噳(y墨ng)銆佷唬璎濊(di脿o)鎺у強鍏剁敓鐗╁(xu茅)鎰忕京锛涗箼閱涢吀寰挵(hu谩n)鍙婂叾鐢熺墿瀛�(xu茅)鎰忕京锛涜憽钀勭硸鐨勭暟
鐢熶綔鐢ㄧ殑绱拌優瀹氫綅銆佷富瑕佸弽鎳�(y墨ng)鍙婂叾鐢熺墿瀛�(xu茅)鎰忕京锛涚硸鍘熺殑鍒嗚В鑸囧悎鎴�锛岀硸鍘熶唬璎濈殑
绱拌優瀹氫綅鍜岃(di脿o)鎺ф鍒�銆�
绗� 2 闋�锛屽叡 2 闋�
锛�3锛夎剛椤炰唬璎濓細鐢樻补涓夐叝鐨勯叾淇冩按瑙ｅ強鍏惰(di脿o)鎺�锛涜剛鑲吀鐨勬哀鍖栵紝閰珨鐨勭敓
鎴愯垏鍒╃敤锛浳�-纾烽吀鐢樻补銆佽剛鑲吀銆佺敇娌逛笁閰殑鍚堟垚鍙婅(di脿o)鎺�锛涘父瑕嬬７鑴傜殑绲�(ji茅)妲�(g貌u)鍜岀７
鑴傜殑浠ｈ瑵锛涜喗鍥洪唶鐨勪唬璎�銆�
锛�4锛夎泲鐧借唱(zh矛)鐨勯檷瑙ｅ拰姘ㄥ熀閰镐唬璎濓細铔嬬櫧璩�(zh矛)閰跺拰铔嬬櫧璩�(zh矛)鐨勯叾淇冩按瑙ｏ紱姘ㄥ熀閰�
鐨勮劔姘ㄥ熀浣滅敤鍜岃劔缇у熀浣滅敤锛屾皑鐨勪唬璎濆拰灏跨礌鐨勫悎鎴愶紝伪-閰吀鐨勪唬璎�锛涙皑鍩洪吀鐨�
鐢熺墿鍚堟垚锛屾皑鍩洪吀浠ｈ瑵鑸囦竴纰冲柈浣�銆�
锛�5锛夋牳閰哥殑闄嶈В鍜屾牳鑻烽吀鐨勪唬璎濓細鏍搁吀鐨勯叾淇冮檷瑙ｏ紝闄愬埗鎬ф牳閰稿収(n猫i)鍒囬叾鍙�
鍏舵噳(y墨ng)鐢�锛涙牳鑻烽吀鐨勫垎瑙ｄ唬璎濓紝鏍歌嫹閰哥殑鐢熺墿鍚堟垚鍙婂叾瑾�(di脿o)鎺�銆�
锛�6锛夌墿璩�(zh矛)浠ｈ瑵鐩镐簰鑱�(li谩n)绯诲拰瑾�(di脿o)鎺э細绯栥€佽剛銆佽泲鐧借唱(zh矛)鍜屾牳閰镐唬璎濈殑鐩镐簰鑱�(li谩n)绯伙紱
浠ｈ瑵瑾�(di脿o)绡€(ji茅)鐨勬蹇�锛岄叾娲绘€у拰閰跺惈閲忕殑瑾�(di脿o)绡€(ji茅)锛屾縺绱犲拰绁炵稉(j墨ng)灏嶇墿璩�(zh矛)浠ｈ瑵鐨勮(di脿o)绡€(ji茅)銆�
3. 閬哄偝淇℃伅鐨勫偝閬炲強琛ㄩ仈瑾�(di脿o)鎺э紙鍒嗗瓙鐢熺墿瀛�(xu茅)锛�
锛�1锛塂NA 鐨勫京(f霉)鍒惰垏淇京(f霉)锛欴NA 鐨勫京(f霉)鍒堕珨绯伙紝DNA 鐨勫崐淇濈暀寰�(f霉)鍒跺拰鍗婁笉閫�
绾�(x霉)寰�(f霉)鍒�锛涘師鏍哥敓鐗� DNA 鐨勫京(f霉)鍒堕亷绋嬪拰鐪熸牳鐢熺墿 DNA 寰�(f霉)鍒剁殑鐗归粸锛孌NA 寰�(f霉)鍒剁殑
蹇犲鎬�锛涢€嗚綁(zhu菐n)閷勯叾鍜岄€嗚綁(zhu菐n)閷�锛汥NA 鎼嶅偡鐨勬蹇靛拰淇京(f霉)鐨勬柟寮�銆�
锛�2锛塕NA 鐨勭敓鐗╁悎鎴愯垏鍔犲伐锛氬師鏍稿拰鐪熸牳鐢熺墿 RNA 鐨勫悎鎴愰珨绯伙紝RNA 鍚�
鎴愰亷绋嬪強鍏惰(di脿o)鎺�锛孯NA 鐢熺墿鍚堟垚鐨勬姂鍒跺姂锛涘師鏍稿拰鐪熸牳鐢熺墿 RNA 杞�(zhu菐n)閷勫悗鍔犲伐锛�
RNA 鐨勭法杓�锛汻NA 鐨勫京(f霉)鍒�锛涢€嗚綁(zhu菐n)閷�銆�
锛�3锛夎泲鐧借唱(zh矛)鐨勭敓鐗╁悎鎴愯垏鍔犲伐锛氳泲鐧借唱(zh矛)鐨勫悎鎴愰珨绯�锛屾牳绯栭珨绲�(ji茅)妲�(g貌u)鑸囧姛鑳�锛�
閬哄偝瀵嗙⒓鍙婂叾鐗规€�锛涘師鏍哥敓鐗╄泲鐧借唱(zh矛)鐨勫悎鎴愰亷绋嬪拰鐪熸牳鐢熺墿铔嬬櫧璩�(zh矛)鍚堟垚鐨勭壒榛烇紝
tRNA 鐨勪綔鐢ㄨ垏姘ㄩ叞-tRNA 鍚堟垚閰�锛岃泲鐧借唱(zh矛)鍚堟垚鐨勮(di脿o)鎺у拰蹇犲鎬�锛涘鑲介張鍚堟垚鍚�
鐨勫姞宸�銆佺炕璀悗鐨勪慨椋撅紱淇¤櫉鑲�锛涜泲鐧借唱(zh矛)銆�
锛�4锛夊熀鍥犺〃閬旂殑瑾�(di脿o)鎺э細鍘熸牳鐢熺墿鍩哄洜琛ㄩ仈鐨勬搷绺卞瓙瀛�(xu茅)瑾�锛屼钩绯栨搷绺卞瓙鐨勭祼(ji茅)
妲�(g貌u)鍙婅(di脿o)鎺ф鐞�锛屽弽缇� RNA銆丷NA 骞叉摼鍜岄潪绶ㄧ⒓ RNA 鐨勬蹇靛強鍏朵綔鐢�锛涚湡鏍哥敓
鐗╁熀鍥犺〃閬旂殑杞�(zhu菐n)閷勫拰缈昏姘村钩瑾�(di脿o)鎺э紱
锛�5锛夐噸绲� DNA 鎶€琛�(sh霉)锛涚爺绌惰泲鐧借唱(zh矛)鐩镐簰浣滅敤鐨勪富瑕佹柟娉曞拰鎶€琛�(sh霉)锛涘熀鍥犵祫瀛�(xu茅)銆�
4. 鐢熺墿鍖栧(xu茅)闋�(l菒ng)鍩熺殑鐣跺墠鐮旂┒鐔遍粸鍙婃柊閫插睍
鍙冭€冩浉
銆婄敓鐗╁寲瀛�(xu茅)鍘熺悊锛堢 2 鐗堬級銆�锛� 妤婃Ξ姝� 涓荤法锛岄珮绛夋暀鑲插嚭鐗堢ぞ锛孖SBN锛�
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鍏嶈铂鑱叉槑锛氭湰鏂囩郴杞�(zhu菐n)杓夎嚜缍�(w菐ng)绲�(lu貌)锛屽鏈変镜鐘�锛岃珛鑱�(li谩n)绯绘垜鍊戠珛鍗冲埅闄わ紝鍙︼細鏈枃鍍呬唬琛ㄤ綔鑰呭€嬩汉瑙€榛�锛岃垏鏈恫(w菐ng)绔欑劇闂�(gu膩n)銆傚叾鍘熷壍(chu脿ng)鎬т互鍙婃枃涓櫝杩版枃瀛楀拰鍏�(n猫i)瀹规湭缍�(j墨ng)鏈珯璀夊锛屽皪鏈枃浠ュ強鍏朵腑鍏ㄩ儴鎴栬€呴儴鍒嗗収(n猫i)瀹�銆佹枃瀛楃殑鐪熷鎬�銆佸畬鏁存€с€佸強鏅傛€ф湰绔欎笉浣滀换浣曚繚璀夋垨鎵胯锛岃珛璁€鑰呭儏浣滃弮鑰�锛屽苟璜嬭嚜琛屾牳瀵︾浉闂�(gu膩n)鍏�(n猫i)瀹广€�
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鏂囩珷鎼滅储
鎮ㄧ従(xi脿n)鍦ㄧ殑浣嶇疆锛� 
