|
鍙嬫儏鎻愮ず锛氭湰绔欐彁渚涘叏鍦�400澶氭墍楂樼瓑闄㈡牎鎷涙敹纰╁＋銆佸崥澹爺绌剁敓鍏ュ(xu茅)鑰冭│姝峰勾鑰冪爺鐪熼銆佽€冨崥鐪熼銆佺瓟妗�锛岄儴鍒嗗(xu茅)鏍℃洿鏂拌嚦2012骞�锛�2013骞�锛涘潎鎻愪緵鏀惰不涓嬭級銆� 涓嬭級娴佺▼锛� 鑰冪爺鐪熼 榛炴搳鈥�鑰冪爺瑭﹀嵎鈥濃€濅笅杓�; 鑰冨崥鐪熼 榛炴搳鈥�鑰冨崥瑭﹀嵎搴�鈥� 涓嬭級
杈�(n贸ng)妤�(y猫)宸ョ▼鑸囬鍝佺瀛�(xu茅)瀛�(xu茅)闄�
纰╁＋鐮旂┒鐢熸嫑鐢熻€冭│鑷懡椤岃€冭│澶х侗
绉戠洰浠ｇ⒓锛�832 绉戠洰鍚嶇ū锛氶鍝佸寲瀛�(xu茅)
鑰冭│鑼冨湇瑾槑锛氶鍝佸寲瀛�(xu茅)鐨勬蹇靛強鐮旂┒鍏�(n猫i)瀹�锛涙按鍒�锛涚⒊姘村寲鍚堢墿锛涜剛椤炲寲鍚堢墿锛涜泲鐧借唱(zh矛)锛涚董鐢熺礌锛�
绀︾墿璩�(zh矛)锛涢鍝佷腑鐨勮壊绱犵墿璩�(zh矛)锛涢鍝佹粙鍛冲拰鍛堝懗鐗╄唱(zh矛)锛涢鍝侀姘ｅ拰鍛堥鐗╄唱(zh矛)锛涢鍝佹坊鍔犲姂銆�
涓€銆佹按鐨勭祼(ji茅)妲�(g貌u)鍜岀悊鍖栫壒鎬э紱椋熷搧涓殑姘村垎鐙€鎱�(t脿i)锛涙按鍒嗘椿搴﹀拰姘村垎绛夋韩鍚告繒绶氱殑姒傚康鍜屾剰缇�锛屾按
鍒嗘椿搴﹀拰椋熷搧绌�(w臎n)瀹氭€т箣闁撶殑闂�(gu膩n)绯�銆�
浜�銆佺⒊姘村寲鍚堢墿鐨勬蹇�銆佺祼(ji茅)妲�(g貌u)鍜屽垎椤�锛岄鍝佷腑涓昏纰虫按鍖栧悎鐗�锛涘柈銆侀洐绯栧湪椋熷搧鎳�(y墨ng)鐢ㄦ柟闈㈢殑鐗�
鐞嗗強鍖栧(xu茅)鎬ц唱(zh矛)锛涙穩绮夌殑鐗规€у湪椋熷搧涓殑鎳�(y墨ng)鐢細绯婂寲銆佽€佸寲鐨勬鐞�銆佸奖闊垮洜绱犲強浣滅敤锛岀景姘ㄨ璁婄殑鍙�
鎳�(y墨ng)姗熺悊銆佸奖闊垮洜绱犲強鍏舵噳(y墨ng)鐢�锛涙灉鑶犲嚌鑶犵殑褰㈡垚姗熺悊銆佸奖闊垮洜绱犲強鍏跺湪椋熷搧涓殑鎳�(y墨ng)鐢�锛涢鍝佷腑鐨勪綆鑱�
绯栧拰鑶抽绾栫董銆�
涓�銆佽剛椤炲寲鍚堢墿鐨勫叡鍚岀壒寰�銆佸垎椤烇紱澶╃劧鑴傝偑鍙婅剛鑲吀鐨勭祫鎴愬拰鍛藉悕锛涙补鑴傜殑鐗╃悊鎬ц唱(zh矛)锛屾补鑴�
鍦ㄥ姞宸ャ€佽帛钘忛亷绋嬩腑鐨勮畩鍖�锛涙补鑴傛按瑙ｅ拰娌硅剛閰告晽鐨勬蹇�銆佹鐞嗗強褰遍熆鍥犵礌锛涙补鑴傜殑璩�(zh矛)閲忚⿻鍍�锛岀７
鑴傚拰鑶藉浐閱囩殑绲�(ji茅)妲�(g貌u)鍜屾€ц唱(zh矛)銆�
鍥涖€佽泲鐧借唱(zh矛)鐨勭祫鎴愬強绲�(ji茅)妲�(g貌u)锛涜泲鐧借唱(zh矛)鐨勫垎椤烇紱姘ㄥ熀閰哥殑鐞嗗寲鎬ц唱(zh矛)锛涜泲鐧借唱(zh矛)鐨勭悊鍖栨€ц唱(zh矛)锛岃畩鎬т綔鐢�銆�
鑶犻珨鐗规€�銆佹矇娣€浣滅敤绛夋鐞嗗強褰遍熆鍥犵礌锛涜泲鐧借唱(zh矛)鍦ㄩ鍝佸姞宸�銆佽帛钘忛亷绋嬩腑鐧�(f膩)鐢熺殑鐗╃悊銆佸寲瀛�(xu茅)鍙婄嚐椁�(y菐ng)
璁婂寲浠ュ強濡備綍鍒╃敤鎴栭槻姝㈤€欎簺璁婂寲銆�
浜�銆佺董鐢熺礌鐨勬蹇靛強鐢熺墿瀛�(xu茅)鎰忕京锛岀董鐢熺礌鐨勫垎椤炲強渚嗘簮锛涢鍝佷腑缍敓绱犲湪鍔犲伐銆佽帛钘忎腑鐨勮畩鍖�銆�
鍏�銆侀鍝佷腑绀︾墿璩�(zh矛)鐨勫垎椤炲強鍏跺瓨鍦ㄥ舰寮忥紱绀︾墿璩�(zh矛)鍦ㄧ敓鐗╅珨鍏�(n猫i)鐨勫姛鑳�锛涚う鐗╄唱(zh矛)灏嶉鍝佹€х媭鐨勫奖闊匡紱
绀︾墿璩�(zh矛)鐨勭敓鐗╂湁鏁堟€у強褰遍熆鐢熺墿鏈夋晥鎬х殑鍥犵礌锛涢吀鎬ч鍝佽垏鍫挎€ч鍝�銆�
涓�銆佺墿璩�(zh矛)椤忚壊鑸囩祼(ji茅)妲�(g貌u)鐨勯棞(gu膩n)绯�锛涢鍝佷腑鐨勫ぉ鐒惰壊绱犺垏鍚堟垚鑹茬礌锛涜憠缍犵礌銆佽绱呯礌銆佸閰氶鑹茬礌鐨�
鎬ц唱(zh矛)銆佸姞宸ヨ帛钘忛亷绋嬩腑鐨勮畩鍖栧強鎶戝埗鎺柦锛涢叾淇冭璁婄殑鍙嶆噳(y墨ng)姗熺悊鍙婂奖闊垮洜绱�銆�
鍏€侀鍝佸懗鐨勫舰鎴愬強鍒嗛锛涢鍝佷腑鍚勭ó鍛堝懗鐗╄唱(zh矛)鐨勫憟鍛崇壒榛炲強鍏跺湪椋熷搧鍔犲伐涓殑鎳�(y墨ng)鐢�銆�
涔�銆佸梾瑕虹敓鐞嗗(xu茅)锛涘寲鍚堢墿鐨勬埃鍛冲拰鍒嗗瓙绲�(ji茅)妲�(g貌u)锛涢鍝佷腑姘ｅ懗鎴愬垎鍙婂叾褰㈡垚閫斿緫锛涢鍝侀鍛冲寮峰姂
鐨勭壒榛炲強鍏跺湪椋熷搧涓殑鎳�(y墨ng)鐢�銆�
鍗�銆侀鍝佹坊鍔犲姂鐨勬蹇点€佷綔鐢�銆佸垎椤�銆侀鍝佹坊鍔犲姂鐨勪竴鑸姹傦紱甯歌椋熷搧娣诲姞鍔�銆�
绉戠洰浠ｇ⒓锛�834 绉戠洰鍚嶇ū锛氶鍝佺敓鐗╁寲瀛�(xu茅)
鑰冭│鑼冨湇瑾槑锛氱敓鐗╁垎瀛愮殑绲�(ji茅)妲�(g貌u)鍙婃€ц唱(zh矛)锛堜富瑕佸寘鎷牳閰歌垏閰讹級锛涚敓鐗╅珨鐨勮兘閲忎唬璎濓紙鐢熺墿姘у寲鑸囨哀
鍖栫７閰稿寲銆佺硸鐨勫垎瑙ｈ垏鍚堟垚浠ｈ瑵銆佽剛浠ｈ瑵銆佽泲鐧借唱(zh矛)鐨勯檷瑙ｈ垏姘ㄥ熀閰哥殑浠ｈ瑵锛�锛涘ぇ鍒嗗瓙鍓嶉珨鐨勭敓鐗╁悎
鎴愶紙姘ㄥ熀閰哥敓鐗╁悎鎴�銆佹牳閰哥殑闄嶈В鍙婃牳鑻烽吀鐨勪唬璎濓級锛涢伜鍌充俊鎭殑鍎插瓨銆佸偝閫佸拰琛ㄩ仈锛堟牳閰哥殑鐢熺墿
鍚堟垚銆佽泲鐧借唱(zh矛)鐨勭敓鐗╁悎鎴愬強浠ｈ瑵瑾�(di脿o)绡€(ji茅)锛夈€�
涓€銆佹牳閰哥殑绲�(ji茅)妲�(g貌u)鑸囧姛鑳�
鏍搁吀鐨勭ó椤炪€佸寲瀛�(xu茅)绲勬垚鍙婄敓鐗╁(xu茅)鍔熻兘锛涙牳閰哥殑涓€绱氱祼(ji茅)妲�(g貌u)銆丏NA 鐨勪簩绱氬強楂樼礆绲�(ji茅)妲�(g貌u)銆佽垏铔嬬櫧璩�(zh矛)鍚�
鎴愭湁闂�(gu膩n)鐨勪笁绋� RNA 鐨勭祼(ji茅)妲�(g貌u)鐗归粸锛涙牳閰哥殑鐞嗗寲鎬ц唱(zh矛)鍙婃噳(y墨ng)鐢ㄣ€�
浜�銆侀叾
閰剁殑鍩烘湰姒傚康銆佸偓鍖栦綔鐢ㄧ殑鐗瑰緛鍙婇叾鐨勫垎椤�锛涢叾鍌寲浣滅敤鐨勬鐞�銆佸奖闊块叾淇冨弽鎳�(y墨ng)閫熷害鐨勫洜绱�锛�
閰舵椿鎬х殑瑾�(di脿o)绡€(ji茅)锛涢叾鐨勬椿鍔涙脯瀹�銆佸垎闆㈡彁绱斿強鍦ㄩ鍝佸伐妤�(y猫)涓殑浣滅敤锛涚董鐢熺礌鑸囪紨閰�銆�
涓�銆佺硸浠ｈ瑵
闆欑硸鑸囧绯栫殑閰朵績闄嶈В锛涚硸閰佃В銆佷笁缇ч吀寰挵(hu谩n)銆佺７閰告垔绯栭€斿緫鍜岀硸閱涢吀閫斿緫锛涜敆绯栧拰澶氱硸鐨勫悎
鎴愶紱绯栫殑鐣扮敓浣滅敤銆�
鍥�銆佺敓鐗╂哀鍖�
鐢熺墿姘у寲鐨勬蹇�銆佺敓鐗╂哀鍖栫殑鐗归粸鍜岄鍨嬶紱闆诲瓙鍌抽仦閺�锛涙哀鍖栫７閰稿寲锛涘叾浠栨湯绔哀鍖栭叾绯荤当(t菕ng)銆�
浜�銆佽剛椤炰唬璎�
鑴傝偑鐨勫垎瑙ｄ唬璎濓紙鐢樻补鐨勯檷瑙ｏ紝鑴傝偑閰哥殑鍒嗚В浠ｈ瑵锛�銆佽剛鑲殑鍚堟垚浠ｈ瑵锛堢敇娌圭殑鐢熺墿鍚堟垚锛岃剛
鑲吀鐨勭敓鐗╁悎鎴愶紝鐢樻补涓夎剛鐨勫悎鎴愶級銆�
鍏�銆佽泲鐧借唱(zh矛)鐨勯叾淇冮檷瑙ｅ拰姘ㄥ熀閰镐唬璎�
铔嬬櫧璩�(zh矛)鐨勯叾淇冮檷瑙�锛涙皑鍩洪吀鐨勫垎瑙ｈ垏杞�(zhu菐n)鍖�锛涚敓鐗╁浐姘垏姘ㄧ殑鍚屽寲锛涙皑鍩洪吀鐨勭敓鐗╁悎鎴�銆�
涓冦€佹牳閰镐唬璎�
鏍搁吀鐨勯叾淇冮檷瑙�銆佸槍鍛ゅ拰鍢у暥鐨勫垎瑙ｅ拰鏍歌嫹閰哥殑鐢熺墿鍚堟垚锛汥NAR 鐨勭敓鐗╁悎鎴愶紱RNA 鐨勭敓鐗╁悎鎴�銆�
鍏�銆佽泲鐧借唱(zh矛)鐨勭敓鐗╁悎鎴�
鍙冭垏铔嬬櫧璩�(zh矛)鐢熺墿鍚堟垚鐨勯珨绯伙紱铔嬬櫧璩�(zh矛)鐨勭敓鐗╁悎鎴愰亷绋�銆佺炕璀悗鍔犲伐銆�
涔�銆佺墿璩�(zh矛)浠ｈ瑵鐨勮伅(li谩n)绯诲強鍏惰(di脿o)绡€(ji茅)
鐗╄唱(zh矛)浠ｈ瑵閫斿緫鐨勭浉浜掕伅(li谩n)绯�锛涗唬璎濊(di脿o)绡€(ji茅)姒傝堪銆佺窗鑳炲崁(q奴)鍩熷寲瑾�(di脿o)绡€(ji茅)銆侀叾姘村钩瑾�(di脿o)绡€(ji茅)銆佹縺绱犳按骞崇殑瑾�(di脿o)绡€(ji茅)鍙�
绁炵稉(j墨ng)姘村钩鐨勮(di脿o)绡€(ji茅)銆�
鍏嶈铂(z茅)鑱叉槑锛氭湰鏂囩郴杞�(zhu菐n)杓夎嚜缍�(w菐ng)绲�(lu貌)锛屽鏈変镜鐘�锛岃珛鑱�(li谩n)绯绘垜鍊戠珛鍗冲埅闄わ紝鍙︼細鏈枃鍍呬唬琛ㄤ綔鑰呭€嬩汉瑙€榛�锛岃垏鏈恫(w菐ng)绔欑劇闂�(gu膩n)銆傚叾鍘熷壍(chu脿ng)鎬т互鍙婃枃涓櫝杩版枃瀛楀拰鍏�(n猫i)瀹规湭缍�(j墨ng)鏈珯璀夊锛屽皪鏈枃浠ュ強鍏朵腑鍏ㄩ儴鎴栬€呴儴鍒嗗収(n猫i)瀹�銆佹枃瀛楃殑鐪熷鎬с€佸畬鏁存€�銆佸強鏅傛€ф湰绔欎笉浣滀换浣曚繚璀夋垨鎵胯锛岃珛璁€鑰呭儏浣滃弮鑰�锛屽苟璜嬭嚜琛屾牳瀵︾浉闂�(gu膩n)鍏�(n猫i)瀹广€�
|
鏂囩珷鎼滅储
鎮ㄧ従(xi脿n)鍦ㄧ殑浣嶇疆锛� 
