鍙嬫儏鎻愮ず锛氭湰绔欐彁渚涘叏鍦�400澶氭墍楂樼瓑闄㈡牎鎷涙敹纰╁+銆佸崥澹爺绌剁敓鍏ュ(xu茅)鑰冭│姝峰勾鑰冪爺鐪熼銆佽€冨崥鐪熼銆佺瓟妗�锛岄儴鍒嗗(xu茅)鏍℃洿鏂拌嚦2012骞�锛�2013骞�锛涘潎鎻愪緵鏀惰不(f猫i)涓嬭級銆� 涓嬭級娴佺▼锛� 鑰冪爺鐪熼 榛�(di菐n)鎿娾€�鑰冪爺瑭﹀嵎鈥濃€濅笅杓�; 鑰冨崥鐪熼 榛�(di菐n)鎿娾€�鑰冨崥瑭﹀嵎搴�鈥� 涓嬭級
閲嶆叾閮甸浕澶у(xu茅)2017骞寸ⅸ澹爺绌剁敓鍏ュ(xu茅) 銆婄敓鐗╀俊鎭(xu茅)锛團20锛夈€嬭€冭│澶х侗
鑰冭│鍏�(n猫i)瀹瑰拰瑕佹眰 鐢熺墿淇℃伅瀛�(xu茅)鏄竴闁€鐮旂┒鐢熺墿鍜岀敓鐗╃浉闂�(gu膩n)绯荤当(t菕ng)涓俊鎭収(n猫i)瀹瑰拰淇℃伅娴佸悜鐨勭稖鍚堟€х瀛�(xu茅)銆傚畠閲囩敤淇℃伅绉戝(xu茅)銆� 瑷�(j矛)绠楁(j墨)绉戝(xu茅)銆佺敓鐗╂暩(sh霉)瀛�(xu茅)銆佹瘮杓冪敓鐗╁(xu茅)绛夊(xu茅)绉戠殑瑙€榛�(di菐n)鍜屾柟娉曞皪(du矛)鐢熷懡鐨勭従(xi脿n)璞″強鍏剁祫鎴愬垎瀛愶紙鏍搁吀銆佽泲鐧借唱(zh矛)绛夛級 閫�(j矛n)琛岀爺绌�锛屼富瑕佺爺绌剁敓鍛戒腑鐨勬湰璩�(zh矛)鍜岃(gu墨)寰嬶紝鍖呮嫭鐗╄唱(zh矛)绲勬垚銆佺祼(ji茅)妲�(g貌u)鍔熻兘銆佺敓鍛介珨鐨勮兘閲忓拰淇℃伅浜ゆ彌鍌抽仦绛�銆� 閫氶亷灏�(du矛)鐢熺墿淇℃伅鐨勮▓(j矛)绠楄檿鐞�锛屼汉鍊戣兘寰炵溇澶氬垎鏁g殑鐢熺墿瀛�(xu茅)瑙€娓�(c猫)鏁�(sh霉)鎿�(j霉)涓嵅寰楀皪(du矛)鐢熷懡閬�(y霉n)琛屾(j墨)鍒剁殑瑭崇窗(x矛)鑰岀郴绲�(t菕ng)鐨� 鐞嗚В銆� 鑰冭│鍏�(n猫i)瀹� 鈽� 鈽� 鈽� 鈽� 鐢熺墿淇℃伅瀛�(xu茅)姒傝珫鍜屾暩(sh霉)鎿�(j霉)搴� 搴忓垪鏁�(sh霉)鎿�(j霉)鐨勬敹闆嗗拰瀛樺劜(ch菙) 鍩哄洜绲勫簭鍒楃祫瑁濆拰鍩哄洜娉ㄩ噵 鍩哄洜绲�(ji茅)妲�(g貌u)鍏冧欢璀�(sh铆)鍒ュ拰鍒嗘瀽 闆欏簭鍒楄垏澶氬簭鍒楁瘮灏�(du矛) 鏁�(sh霉)鎿�(j霉)搴绱㈢畻娉� 鈽� 鈽� 鈽� 鈽� 鈽� 鈽� 鈽� 鈽� 搴忓垪璁婄暟鐮旂┒鐨勭畻娉曡垏閫�(j矛n)鍖栧垎鏋� 鏁�(sh霉)鎿�(j霉)鐨勫彲瑕栧寲 RNA浜岀礆(j铆)绲�(ji茅)妲�(g貌u)闋�(y霉)娓�(c猫) 鍩哄洜琛ㄩ仈(d谩)鑸囪(di脿o)鎺х恫(w菐ng)绲�(lu貌) 琛ㄨ閬哄偝瀛�(xu茅)鏁�(sh霉)鎿�(j霉)鍒嗘瀽 铔嬬櫧璩�(zh矛)鍒嗛鑸囩祼(ji茅)妲�(g貌u)闋�(y霉)娓�(c猫) 鑰冭│瑕佹眰 浜嗚В鐢熺墿淇℃伅瀛�(xu茅)姒傚康銆佺爺绌舵柟鍚戙€佺櫦(f膩)灞曡定鍕�(sh矛)鍜岄噸瑕佷簨浠�锛屽寘鎷硾鍩哄洜绲勫拰鍏冨熀鍥犵祫鐨勬蹇碉紝绗竴鍊�(g猫)
鍏ㄥ熀鍥犵祫搴忓垪鍜岀涓€鍊�(g猫)鍩哄洜绲勬暩(sh霉)鎿�(j霉)搴殑鐢�(ch菐n)鐢熺瓑銆� 浜嗚В閲嶈鐨勭敓鐗╀俊鎭腑蹇冨拰甯哥敤鏁�(sh霉)鎿�(j霉)搴紙鍖呮嫭DNA搴忓垪鏁�(sh霉)鎿�(j霉)搴€佸熀鍥犵祫鏁�(sh霉)鎿�(j霉)搴�銆佽泲鐧借唱(zh矛)搴忓垪鍙婄祼(ji茅) 妲�(g貌u)鏁�(sh霉)鎿�(j霉)搴級 浜嗚В涓嶅悓椤炲瀷搴忓垪鏁�(sh霉)鎿�(j霉)鐨勭嵅鍙栨柟寮�锛屾帉鎻″父鐢ㄧ殑搴忓垪瀛樺劜(ch菙)鏍煎紡鍙婅綁(zhu菐n)鎻涙柟寮忋€� 鎺屾彙甯哥敤鐨勫簭鍒楄伅(li谩n)閰嶇畻娉曞強杌熶欢锛屾帉鎻℃墦鍒嗙煩闄e強绌轰綅缃板垎绠楁硶锛岀悊瑙h矟钁夋柉绲�(t菕ng)瑷�(j矛)鍦ㄥ簭鍒楁瘮灏�(du矛)鍜� 閫�(j矛n)鍖栧垎鏋愪腑鐨勬噳(y墨ng)鐢�銆� 鐞嗚В澶氶噸搴忓垪姣斿皪(du矛)鑸囬€�(j矛n)鍖栧垎鏋愮殑闂�(gu膩n)绯伙紝鎺屾彙甯哥敤鐨勬几閫�(j矛n)绠楁硶鍙婅粺浠�锛屾帉鎻$当(t菕ng)瑷�(j矛)绠楁硶鍙婁綅缃壒鐣版€� 鎵撳垎鐭╅櫍銆� 鎺屾彙FASTA鍜孊LAST绯诲垪绠楁硶銆� 鐞嗚В閫�(j矛n)鍖栧垎鏋愯垏瑕罚妯圭殑闂�(gu膩n)绯�锛屾帉鎻′笁绋€�(j矛n)鍖栧垎鏋愮畻娉曪紙鏈€澶т技鐒舵硶銆佽窛闆㈡硶鍜屾渶澶х啊绱勬硶锛�銆� 鎺屾彙澶氱ó鐢熺墿淇℃伅鏁�(sh霉)鎿�(j霉)鐨勫彲瑕栧寲杌熶欢锛屽寘鎷緸闋祫瑁濇暩(sh霉)鎿�(j霉)銆佽畩鐣扮櫦(f膩)鎺樻暩(sh霉)鎿�(j霉)銆佹摯(ku貌)澧炲瓙娣卞害娓�(c猫)搴忔暩(sh霉)鎿�(j霉)銆� 鍩哄洜琛ㄩ仈(d谩)鏁�(sh霉)鎿�(j霉)鍜岃〃瑙€閬哄偝瀛�(xu茅)鏁�(sh霉)鎿�(j霉)绛�锛屼簡瑙d笉鍚岄鍨嬫暩(sh霉)鎿�(j霉)鍙鍖栫殑闆e害鍜屾寫鎴�(zh脿n)銆� 浜嗚ВRNA浜岀礆(j铆)绲�(ji茅)妲�(g貌u)鑸囦笁绱�(j铆)绲�(ji茅)妲�(g貌u)鐨勭壒榛�(di菐n)锛屾帉鎻″叐绋甊NA浜岀礆(j铆)绲�(ji茅)妲�(g貌u)闋�(y霉)娓�(c猫)鏂规硶锛堣兘閲忔渶灏忓寲娉曘€佸牽鍩哄叡 璁婅瓨(sh铆)鍒ワ級銆� 鎺屾彙闁嬫斁闁辫畝妗嗙殑闋�(y霉)娓�(c猫)鏂规硶锛岀悊瑙i噸寰�(f霉)搴忓垪灏�(du矛)鍩哄洜闋�(y霉)娓�(c猫)鐨勫奖闊�锛屾帉鎻″井鐢熺墿鍩哄洜绲勭殑鍩哄洜闋�(y霉)娓�(c猫)锛� 鐞嗚В鐪熸牳鐢熺墿鍩哄洜闋�(y霉)娓�(c猫)鑸囧椤瓙璀�(sh铆)鍒ョ殑闂�(gu膩n)绯伙紝鎺屾彙绁炵稉(j墨ng)缍�(w菐ng)绲�(lu貌)绠楁硶鍜屾ā寮忚瓨(sh铆)鍒ョ畻娉�锛屼簡瑙e暉鍕�(d貌ng)瀛愰爯(y霉)娓�(c猫) 鑸囪(di脿o)鎺фā寮忕殑闂�(gu膩n)绯�锛屼簡瑙h綁(zhu菐n)閷勫洜瀛愮祼(ji茅)鍚堜綅榛�(di菐n)鐨勬蹇靛強浣滅敤銆� 浜嗚В鍘熸牳鐢熺墿鑸囩湡鏍哥敓鐗╁熀鍥犵祫鍒嗘瀽鐨勭暟鍚岄粸(di菐n)锛岀悊瑙e悓婧愭€ц瓨(sh铆)鍒ヨ垏铔嬬櫧绲勫垎鏋�锛屾帉鎻″熀鍥犵祫鍒嗘瀽 鑸囬€�(j矛n)鍖栫殑闂�(gu膩n)绯�锛屼簡瑙e姛鑳藉熀鍥犵祫鐨勭爺绌舵柟娉曘€� 鎺屾彙搴忓垪璁婄暟鐨勬娓�(c猫)鏂规硶銆佸伐鍏枫€佽⿻(p铆ng)浼板強娉ㄩ噵娴佺▼銆� 鎺屾彙杞�(zhu菐n)閷勭祫鍒嗘瀽鍩烘湰鏂规硶锛屽熀鍥犺〃閬�(d谩)宸暟鍒嗘瀽鍙婁唬璎濈恫(w菐ng)绲�(lu貌)鍒嗘瀽鐨勭畻娉曞拰杌熶欢锛岄噸榛�(di菐n)鎺屾彙RNA娓�(c猫)搴� 鏂规硶鐨勬暩(sh霉)鎿�(j霉)铏曠悊鍜屼俊鎭寲鎺�銆� 浜嗚В鏌撹壊璩�(zh矛)鍏嶇柅鍏辨矇娣€鎶€琛�(sh霉)锛屾帉鎻hIP-seq鏁�(sh霉)鎿�(j霉)铏曠悊鏂规硶銆� 鎺屾彙铔嬬櫧璩�(zh矛)绲�(ji茅)妲�(g貌u)鐨勭祫鎴愬拰灞ゆ锛屾帉鎻″簭鍒楃浉浼兼€ц垏绲�(ji茅)妲�(g貌u)鐩镐技鎬у悓铔嬬櫧璩�(zh矛)鍒嗛涔嬮枔鐨勯棞(gu膩n)绯�锛屼簡瑙h泲 鐧借唱(zh矛)绲�(ji茅)妲�(g貌u)姣斿皪(du矛)鏂规硶锛屾帉鎻¤泲鐧借唱(zh矛)绲�(ji茅)妲�(g貌u)闋�(y霉)娓�(c猫)鏂规硶锛屽寘鎷簩绱�(j铆)绲�(ji茅)妲�(g貌u)鍜屼笁绱�(j铆)绲�(ji茅)妲�(g貌u)銆� 鍙冭€冩浉鐩� 1銆併€婄浜屼唬娓�(c猫)搴忎俊鎭檿鐞嗐€婼.M.甯冩湕锛屽惓浣冲锛岃倴鏅櫦(f膩)锛屼簬杌嶏紙璀級锛岀瀛�(xu茅)鍑虹増绀� 2銆併€婂熀鍥犵祫III銆嬶紝T.A.甯冩湕锛岃寤哄墰锛堣锛�锛岀瀛�(xu茅)鍑虹増绀� 3銆併€婄敓鐗╀俊鎭(xu茅)锛氬簭鍒楄垏鍩哄洜绲勫垎鏋愶紙鑻辨枃鐗堬級銆�锛孌avidW.Mount锛岀瀛�(xu茅)鍑虹増绀�
鍏嶈铂(z茅)鑱叉槑锛氭湰鏂囩郴杞�(zhu菐n)杓夎嚜缍�(w菐ng)绲�(lu貌)锛屽鏈変镜鐘紝璜�(q菒ng)鑱�(li谩n)绯绘垜鍊戠珛鍗冲埅闄�锛屽彟锛氭湰鏂囧儏浠h〃浣滆€呭€�(g猫)浜鸿榛�(di菐n)锛岃垏鏈恫(w菐ng)绔欑劇闂�(gu膩n)銆傚叾鍘熷壍(chu脿ng)鎬т互鍙婃枃涓櫝杩版枃瀛楀拰鍏�(n猫i)瀹规湭缍�(j墨ng)鏈珯璀夊(sh铆)锛屽皪(du矛)鏈枃浠ュ強鍏朵腑鍏ㄩ儴鎴栬€呴儴鍒嗗収(n猫i)瀹广€佹枃瀛楃殑鐪熷(sh铆)鎬�銆佸畬鏁存€с€佸強鏅�(sh铆)鎬ф湰绔欎笉浣滀换浣曚繚璀夋垨鎵胯锛岃珛(q菒ng)璁€鑰呭儏浣滃弮鑰冿紝骞惰珛(q菒ng)鑷鏍稿(sh铆)鐩搁棞(gu膩n)鍏�(n猫i)瀹�銆�
|